(n.) The hollow bed where a stream of water runs or may run.
(n.) The deeper part of a river, harbor, strait, etc., where the main current flows, or which affords the best and safest passage for vessels.
(n.) A strait, or narrow sea, between two portions of lands; as, the British Channel.
(n.) That through which anything passes; means of passing, conveying, or transmitting; as, the news was conveyed to us by different channels.
(n.) A gutter; a groove, as in a fluted column.
(n.) Flat ledges of heavy plank bolted edgewise to the outside of a vessel, to increase the spread of the shrouds and carry them clear of the bulwarks.
(v. t.) To form a channel in; to cut or wear a channel or channels in; to groove.
(v. t.) To course through or over, as in a channel.
Example Sentences:
(1) These channels may, at least in some cases, be responsible for the generation of pacemaker depolarizations, thereby regulating firing behaviour.
(2) The influence of the various concepts for the induction of lateral structure formation in lipid membranes on integral functional units like ionophores is demonstrated by analysing the single channel current fluctuations of gramicidin in bimolecular lipid membranes.
(3) RNAs encoding a wild-type (RBK1) and a mutant (RBK1(Y379V,V381T); RBK1*) subunit of voltage-dependent potassium channels were injected into Xenopus oocytes.
(4) The dramas are part of the BBC2 controller Janice Hadlow's plans for her "unashamedly intelligent" channel over the coming months.
(5) This was unlike the action of the calcium channel blocker, cadmium, which reduced the calcium action potential and the a.h.p.
(6) Circuitry has been developed to feed the output of an ear densitogram pickup into one channel of a two-channel Holter monitor.
(7) It is concluded the decrease in cellular volume associated with substitution of serosal gluconate for Cl results in a loss of highly specific Ba2+-sensitive K+ conductance channels from the basolateral plasma membrane.
(8) Stimulation of atrial H1-receptors is suggested to directly cause an increase in Ca-channel conductance independent of intracellular cAMP content.
(9) Similarly, 50 microM D-600, a Ca+2 channel antagonist, significantly (P less than 0.01) reduced basal and 5-HETE-induced PRL release.
(10) The purpose of the present study was to analyze the effects of cromakalim (BRL 34915), a potent drug from a new class of drugs characterized as "K+ channel openers", on the electrical activity of human skeletal muscle.
(11) This promotion of repetitive activity by the introduction of additional potassium channels occurred up to an "optimal" value beyond which a further increase in paranodal potassium permeability narrowed the range of currents with a repetitive response.
(12) Channel activation persists through the process of platelet isolation and washing and is manifested in higher measured values of [Ca2+]cyt and [Ca2+]dt in the "resting state."
(13) At 100 microM-ACh the apparent open time became shorter probably due to channel blockade by ACh molecules.
(14) The effects of low doses of dihydropyridine (DHP) calcium channel antagonists nimodipine, nifedipine, (-)-R-202-791, and amlodipine, the DHP calcium channel agonist BAY K 8644 were investigated on clonic convulsions to pentylenetetrazole (PTZ) in mice.
(15) The following model is suggested: exogenous ATP interacts with a membrane receptor in the presence of Ca2+, a cascade of events occurs which mobilizes intracellular calcium, thereby increasing the cytosolic free Ca2+ concentration which consequently opens the calcium-activated K+ channels, which then leads to a change in membrane potential.
(16) SDS-PAGE analysis of the immunoprecipitates under reducing conditions revealed that the cardiac channel is mainly composed of two large polypeptides of 190 and 150 kDa, and five smaller polypeptides of 60, 55, 35, 30, and 25 kDa.
(17) In the presence of high external Cl, a component of outward current that was inhibited by the anion channel blocker diphenylamine-2-carboxylate (DPC) appeared in 70% of the cells.
(18) In vitro studies in cardiac Purkinje fibers suggested that reversal of amitriptyline-induced cardiac membrane effects by sodium bicarbonate may be attributed not only to alkalinization but also to increased in extracellular sodium concentration, diminishing the local anesthetic action of amitriptyline and resulting in less sodium channel block.
(19) The Ca2+ channel current recorded under identical conditions in rat dorsal root ganglion neurones was less sensitive to blockade by PCP (IC50, 90 microM).
(20) In voltage-clamp experiments the ion current flowing through the channels was homogeneous indicating a defined conformation and a uniform size.
Trench
Definition:
(v. t.) To cut; to form or shape by cutting; to make by incision, hewing, or the like.
(v. t.) To fortify by cutting a ditch, and raising a rampart or breastwork with the earth thrown out of the ditch; to intrench.
(v. t.) To cut furrows or ditches in; as, to trench land for the purpose of draining it.
(v. t.) To dig or cultivate very deeply, usually by digging parallel contiguous trenches in succession, filling each from the next; as, to trench a garden for certain crops.
(v. i.) To encroach; to intrench.
(v. i.) To have direction; to aim or tend.
(v. t.) A long, narrow cut in the earth; a ditch; as, a trench for draining land.
(v. t.) An alley; a narrow path or walk cut through woods, shrubbery, or the like.
(v. t.) An excavation made during a siege, for the purpose of covering the troops as they advance toward the besieged place. The term includes the parallels and the approaches.
Example Sentences:
(1) Its boot always held a bivouac bag, a trenching tool of some sort and a towel and trunks, in case he passed somewhere interesting to sleep, dig, or swim.
(2) The RSC’s Erica Whyman stages a story inspired by a local man, the Royal Warwickshire Regiment’s Captain Bruce Bairnsfather, who was known as the cartoonist of the trenches and survived the war to work at the original Shakespeare Memorial theatre.
(3) Stephen Fisher, one of the archaeologists recording the site, says digging the trenches would also have been training for the men, who would soon have to do it for real, and the little slit trenches scattered across the site, just big enough for one man to cower in, might represent their first efforts.
(4) Upon segregation of the conidium from the phialide cell by conidial wall formation, 'trench-like' invaginations gradually appeared in the plasma membrane and a disorganized rodlet pattern was formed on the outer surface of the maturing conidial wall.
(5) The field was taped off while a mechanical digger clawed at the ground, making parallel trenches in the sandy earth.
(6) Scores of archaeologists working in a waterlogged trench through the wettest summer and coldest winter in living memory have recovered more than 10,000 objects from Roman London , including writing tablets, amber, a well with ritual deposits of pewter, coins and cow skulls, thousands of pieces of pottery, a unique piece of padded and stitched leather – and the largest collection of lucky charms in the shape of phalluses ever found on a single site.
(7) He sees HS2 as a "huge trench across the country where we can learn an awful lot about new sites.
(8) But his attitude gradually hardened, particularly after he reached the trenches.
(9) "It looks solid," said Jean Pascal Zanders, a Belgian expert who runs a blog on chemical weapons called The Trench .
(10) What they learn can be summed up in one word: trenches.
(11) The archaeologists had to wear slippers to preserve the site which, at the bottom of a two-metre trench, picked up much damp.
(12) A variety of cold exposure injuries were discussed, including frostnip, chilblains, trench foot, frostbite, and hypothermia.
(13) Alan Trench, an academic specialising in devolution and adviser to expert government commissions, said: "It's clear that Labour voters generally have concerns about how things are at the moment.
(14) But if trapped deep inside wreckage or an underwater trench, the effectiveness can be hindered.
(15) French troops wearing an early form of gas mask in the trenches during the second Battle of Ypres in 1915.
(16) Keeping within the string lines of your footprint, dig a trench about 15cm deep and lay the foundation stones flat and level.
(17) But according to Wayne Cocroft, an English Heritage expert on wartime archaeology, although 20 other trench training sites have been recorded across Britain, many have been damaged by later development, and both the scale and the state of preservation of the Gosport complex is exceptional.
(18) Working in a location to the southeast of Kathmandu, Paul Tapponnier, an earth scientist at the Earth Observatory of Singapore , and his team dug trenches across the fault and used charcoal to date when it had moved.
(19) There are no trenches, barbed wire fences or tank traps.
(20) Accessory glandular tissues were atrophied and debris filled the trenches of the papillae.