(n.) The hollow bed where a stream of water runs or may run.
(n.) The deeper part of a river, harbor, strait, etc., where the main current flows, or which affords the best and safest passage for vessels.
(n.) A strait, or narrow sea, between two portions of lands; as, the British Channel.
(n.) That through which anything passes; means of passing, conveying, or transmitting; as, the news was conveyed to us by different channels.
(n.) A gutter; a groove, as in a fluted column.
(n.) Flat ledges of heavy plank bolted edgewise to the outside of a vessel, to increase the spread of the shrouds and carry them clear of the bulwarks.
(v. t.) To form a channel in; to cut or wear a channel or channels in; to groove.
(v. t.) To course through or over, as in a channel.
Example Sentences:
(1) These channels may, at least in some cases, be responsible for the generation of pacemaker depolarizations, thereby regulating firing behaviour.
(2) The influence of the various concepts for the induction of lateral structure formation in lipid membranes on integral functional units like ionophores is demonstrated by analysing the single channel current fluctuations of gramicidin in bimolecular lipid membranes.
(3) RNAs encoding a wild-type (RBK1) and a mutant (RBK1(Y379V,V381T); RBK1*) subunit of voltage-dependent potassium channels were injected into Xenopus oocytes.
(4) The dramas are part of the BBC2 controller Janice Hadlow's plans for her "unashamedly intelligent" channel over the coming months.
(5) This was unlike the action of the calcium channel blocker, cadmium, which reduced the calcium action potential and the a.h.p.
(6) Circuitry has been developed to feed the output of an ear densitogram pickup into one channel of a two-channel Holter monitor.
(7) It is concluded the decrease in cellular volume associated with substitution of serosal gluconate for Cl results in a loss of highly specific Ba2+-sensitive K+ conductance channels from the basolateral plasma membrane.
(8) Stimulation of atrial H1-receptors is suggested to directly cause an increase in Ca-channel conductance independent of intracellular cAMP content.
(9) Similarly, 50 microM D-600, a Ca+2 channel antagonist, significantly (P less than 0.01) reduced basal and 5-HETE-induced PRL release.
(10) The purpose of the present study was to analyze the effects of cromakalim (BRL 34915), a potent drug from a new class of drugs characterized as "K+ channel openers", on the electrical activity of human skeletal muscle.
(11) This promotion of repetitive activity by the introduction of additional potassium channels occurred up to an "optimal" value beyond which a further increase in paranodal potassium permeability narrowed the range of currents with a repetitive response.
(12) Channel activation persists through the process of platelet isolation and washing and is manifested in higher measured values of [Ca2+]cyt and [Ca2+]dt in the "resting state."
(13) At 100 microM-ACh the apparent open time became shorter probably due to channel blockade by ACh molecules.
(14) The effects of low doses of dihydropyridine (DHP) calcium channel antagonists nimodipine, nifedipine, (-)-R-202-791, and amlodipine, the DHP calcium channel agonist BAY K 8644 were investigated on clonic convulsions to pentylenetetrazole (PTZ) in mice.
(15) The following model is suggested: exogenous ATP interacts with a membrane receptor in the presence of Ca2+, a cascade of events occurs which mobilizes intracellular calcium, thereby increasing the cytosolic free Ca2+ concentration which consequently opens the calcium-activated K+ channels, which then leads to a change in membrane potential.
(16) SDS-PAGE analysis of the immunoprecipitates under reducing conditions revealed that the cardiac channel is mainly composed of two large polypeptides of 190 and 150 kDa, and five smaller polypeptides of 60, 55, 35, 30, and 25 kDa.
(17) In the presence of high external Cl, a component of outward current that was inhibited by the anion channel blocker diphenylamine-2-carboxylate (DPC) appeared in 70% of the cells.
(18) In vitro studies in cardiac Purkinje fibers suggested that reversal of amitriptyline-induced cardiac membrane effects by sodium bicarbonate may be attributed not only to alkalinization but also to increased in extracellular sodium concentration, diminishing the local anesthetic action of amitriptyline and resulting in less sodium channel block.
(19) The Ca2+ channel current recorded under identical conditions in rat dorsal root ganglion neurones was less sensitive to blockade by PCP (IC50, 90 microM).
(20) In voltage-clamp experiments the ion current flowing through the channels was homogeneous indicating a defined conformation and a uniform size.
Wale
Definition:
(n.) A streak or mark made on the skin by a rod or whip; a stripe; a wheal. See Wheal.
(n.) A ridge or streak rising above the surface, as of cloth; hence, the texture of cloth.
(n.) A timber bolted to a row of piles to secure them together and in position.
(n.) Certain sets or strakes of the outside planking of a vessel; as, the main wales, or the strakes of planking under the port sills of the gun deck; channel wales, or those along the spar deck, etc.
(n.) A wale knot, or wall knot.
(v. t.) To mark with wales, or stripes.
(v. t.) To choose; to select; specifically (Mining), to pick out the refuse of (coal) by hand, in order to clean it.
Example Sentences:
(1) The Wales international and Port Vale defender Clayton McDonald both admitted having sex with the victim, – McDonald was found not guilty of the same charge.
(2) Numerical results for the population of England and Wales are shown.
(3) Blood gas variables produced from a computed in vivo oxygen dissociation curve, PaeO2, P95 and C(a-x)O2, were introduced in the University Hospital of Wales in 1986.
(4) Any party or witness is entitled to use Welsh in any magistrates court in Wales without prior notice.
(5) It may not point to independence – nor, given that large swaths of Wales remain firmly dominated by Labour, mean any huge advance for Plaid Cymru.
(6) Harry was 12 years old when Diana, Princess of Wales, was killed in a car crash but said it was not until his late 20s, after two years of “total chaos”, that he processed the grief.
(7) Hospitals in Wales collected £5.4m in parking charges in 2006-07 and hospitals in England took more than £100m.
(8) So Fifa left that group out and went ahead with the draw – according to legend, plucking names from the Jules Rimet trophy itself – and, after Belgium were chosen but decided not to participate, Wales came out next.
(9) Bringing the Prince of Wales into service “will involve very considerable additional costs, additional manpower, extra aircraft and the considerable amount of support and protection needed to make it viable”, say the MPs.
(10) But he won’t call.” Allardyce is also cynical about an offer from Swansea to compensate around 300 Sunderland fans who had booked trips to Wales before the date change.
(11) The bill will create a six-month time limit for family courts in England and Wales to reach decisions on whether children should be taken into care and will require the court to take into account the impact of delays on the child.
(12) There were a record 354 deaths in prisons in England and Wales in 2016.
(13) 31 October TB met the Prince of Wales after he took Prince William hunting.
(14) The annual number of confirmed cases of Legionnaires' disease in both Nottingham, and England and Wales, reached a peak in 1980 and has since declined.
(15) A comprehensive analysis of repeat rates has been obtained from an observational study of radiological practice in diagnostic X-ray departments throughout Wales.
(16) The most recent figures show 3,046 confirmed cases in England and Wales, compared with 1,669 cases last winter.
(17) In north Wales, Llandudno town council has had to cancel its annual display at short notice after it was told it would have to pay at least £22,000 to insure the wonderful Victorian pier in case of a fire.
(18) When he was prime minister Tony Blair asked Peter Mandelson to tell the Prince of Wales to stop his "unhelpful" attempts to influence policy on GM and Mandelson accused him of being "anti-scientific and irresponsible".
(19) Others, like eight-year-old Stan – who was playing football with his mates in a corner of the beer-soaked field, has only good memories of Wales.
(20) A spokesperson for Plaid Cymru said: “On 5 May, Wales chose not to elect one single party to govern Wales with a majority.