What's the difference between chelate and cholate?
Chelate
Definition:
(a.) Same as Cheliferous.
Example Sentences:
(1) The LD50 of the following metal-binding chelating drugs, EDTA, diethylenetriaminepentaacetic acid (DTPA), hydroxyethylenediaminetriacetic acid (HEDTA), cyclohexanediaminotetraacetic acid (CDTA) and triethylenetetraminehexaacetic acid (TTHA) was evaluated in terms of mortality in rats after intraperitoneal administration and was found to be in the order: CDTA greater than EDTA greater than DTPA greater than TTHA greater than HEDTA.
(2) These membrane perturbation effects not observed with bleomycin-iron in the presence of a hydroxyl radical scavenger, dimethyl thiourea, or a chelating agent, desferrioxamine, were correlated with the ability of the complex to generate highly reactive oxygen species.
(3) Symptoms, particularly colicky abdominal pain, improved during the period of chelation therapy.
(4) The present study explored the possibility that SOD-mimics such as desferrioxamine-Mn(III) chelate [DF-Mn] or cyclic nitroxide stable free radicals could protect from O2-.-independent damage.
(5) Chelators and sulfhydryl group reacting substances reduced the enzyme activity.
(6) Co2+ partially restored the activities lost by chelation.
(7) A chelator, dichloromethane diphosphonate (Cl2MDP), used to treat for malignancy-induced hypercalcemia, has nephrotoxic potential.
(8) This procedure, using mixed ligand chelate systems, may well be one which is limited to conditions more narrowly similar to those reported by Schubert and Derr (1978).
(9) Since the enzyme requires a metal ion (Co2+) we suggest that the RNA and heparin are inhibitory by virtue of their capacity to chelate the Co2+.
(10) Due to the higher stability constant, of MgCDTA, as compared to MgEDTA, addition of CDTA to a medium containing free Mg2+ and MgEDTA will not only chelate the free Mg2+, but it will also shift the equilibrium from MgEDTA towards MgCDTA, i.e.
(11) Their ability to inhibit iron-ion-dependent formation of .OH from H2O2 by chelating iron ions was also tested.
(12) The interest of monitoring lead excretion during chelation therapy is particularly emphasized.
(13) The data obtained testify to the presence in the granular fraction of the endopeptidase LTH-converting activity which is sensitive to pepstatin A, an aspartyl proteinase inhibitor as well as to chelators and a serine proteinase inhibitor.
(14) Chelation of extracellular calcium with ethyleneglycol-bis(beta-aminoethyl ether)N,N,N',N' tetraacetic acid (EGTA) did not abolish the increase in calcium.
(15) One was identified as viridomycin A, the ferrous chelate of 4-hydroxy-3-nitrosobenzaldehyde; the second (actinoviridin A) was the corresponding carboxylic acid chelate and the third (viridomycin E) was a hybrid chelate containing both the aldehyde and acid ligands.
(16) The ferrous iron chelator, bipyridyl, enhanced the production of chemiluminescence catalyzed by FeSO4 and ferritin but had little effect on the K3Fe(CN)6-catalyzed reaction.
(17) Kininase activity in the glomerulus and the proximal tubule was completely inhibited by chelating agents.
(18) Both enzymes are strongly inhibited by metal-chelating agents.
(19) Accumulated cysteine may chelate iron, accounting for the local increase in iron content in Hallervorden-Spatz disease.
(20) The efficiency of hydroxyl radical generation varied with the nature of the iron chelators used and increased in the order of phosphate alone approximately ADP less than EDTA less than diethylenetriaminepentaacetic acid (DETAPAC).
Cholate
Definition:
(n.) A salt of cholic acid; as, sodium cholate.
Example Sentences:
(1) The P400 protein is purified by successive extraction of synaptosomal and microsomal membranes with 2% Triton X-100 and 25% Na-cholate and preparative gel electrophoresis in SDS.
(2) The denatured protein was digested with trypsin and the cholate-labeled tryptic peptide was isolated.
(3) The hydrolysis of a series of n-alkyl esters of 4-nitrobenzoic acid, and of isopropyl 4-nitrobenzoate, 4'-nitrophenyl 4-nitrobenzoate, and 4-nitrobenzoyl 1-monoglycerol, catalyzed by human milk lipase in the absence and presence of cholate stimulation, has been measured at pH 7.3, 37.5 degrees C. It has been shown that the enzyme possesses a specific alkyl binding site which is hydrophobic in nature and wide enough to accommodate two fatty acid chains lying side by side or a phenyl ring lying flat.
(4) A protein kinase was isolated from spinach thylakoid membranes by solubilization with octyl glucoside and cholate.
(5) Killing of Giardia lamblia trophozoites by nonimmune human milk in vitro is dependent upon the presence of cholate which activates the milk bile salt-stimulated lipase to cleave fatty acids from milk triglycerides.
(6) Ganglioside GM1 in either the monomeric or micelar form was hydrolyzed to asialo-GM1 by A. ureafaciens sialidase most efficiently in the presence of sodium cholate of about three times the GM1 molar concentration.
(7) As demonstrated by Ficoll density gradient centrifugation and HPLC gel filtration, the cholate dialysis method made the reductase bind tightly to the liposomal membranes, while the incubation with the preformed vesicles made the reductase bind loosely to the membranes.
(8) Experimental work in animals suggests that intrahepatic sodium cholate infusion results in injury to the ductal epithelium and predisposes patients to bactermia and sepsis.
(9) sphaeroides (designated 01) in the presence of 1% sodium cholate.
(10) The in vitro sodium cholate binding of this resin was much more potent than that of cholestyramine.
(11) [14C]cholate was incorporated into tissue and medium conjugates at a constant rate during 21 days in vitro.
(12) Sodium cholate had no significant main effects on the incidence or morphology of colon lesions.
(13) Mixtures of the detergent cholate and phospholipids were found to solubilize PrP 27-30 with full retention of scrapie prion infectivity.
(14) Chenodeoxycholate and cholate behave similarly in terms of the dissolution process as observed by scanning electron microscopy.
(15) A competitive enzyme-linked immunosorbent assay was developed in which inhibition of antibody binding to peptide-coated microtiter plates was used to quantitate purified Gs or Gs in cholate extracts of cell membranes.
(16) A vasopressin receptor was purified, using a novel affinity column, from rat liver plasma membranes treated with guanosine 5'-(3-O-thio)triphosphate and solubilized with 0.8% cholate.
(17) On the other hand, the dihydroxy bile salt ursodeoxycholate and the trihydroxy bile salt cholate solubilize much less lipid.
(18) In addition, sporozoites were added to solutions of triglycerides (trilinolein, triolein and trilinolenin) preincubated with BSSL and sodium cholate, which resulted in killing of the parasites.
(19) The detergents Triton X-100 and sodium cholate inhibited diacylglycerol formation at concentrations in the region of their critical micellar concentration, while n-octyl-beta, D-glyco-pyranoside had no effect, even at high concentration.
(20) A corollary is that daily cholate secretion is likely to be normal in these conditions and that therefore the propensity of bile to form cholesterol gall stones is not likely to be directly related to bile salt pool size.