(n.) A monster represented as vomiting flames, and as having the head of a lion, the body of a goat, and the tail of a dragon.
(n.) A vain, foolish, or incongruous fancy, or creature of the imagination; as, the chimera of an author.
Example Sentences:
(1) The other chimeras accumulated in the plasma membrane, and truncated LEP100 was secreted.
(2) The bone marrow derivation of dThy-1+EC is now well established: dThy-1+EC carry Ly-5 determinants whose expression is restricted to cells of the hemopoietic differentiation pathway, and studies using Thy-1-disparate radiation bone marrow chimeras have revealed the presence of donor-type Thy-1+ cells within the epidermis; by immunoelectron microscopy, these cells represent dThy-1+EC.
(3) Complex I (19S) consists of gRNA, TUTase, RNA ligase and chimera-forming activity.
(4) Direct immunofluorescence tests for chicken IgG were positive in spinal cords of most SS chimeras but only of some LS chimeras.
(5) Tests on five different blood chimeras showed the T- and B-lymphocyte chimerism to be the same.
(6) The peak of GvH foci response occurred near the end of the 1st week when 70% of 950 R-RSp chimera spleens examined contained an average of 18 to 21 foci per spleen.
(7) In control chimeras, the mean ratio of the unlabeled cells:total chimera cell number (henceforth referred to as "mean ratio") was 0.50 with little or no weekly variation over the 9-week experimental period.
(8) Purified parental strain T cells prepared from unprimed chimeras were exposed to sheep erythrocytes in heavily irradiated mice of each of the two parental strains and recovered from thoracic duct lymph of the recipients at either day 1 or day 5 posttransfer.
(9) The quail-chick chimera method was used to examine whether neural crest cells were associated with the formation of semilunar valves.
(10) For this chimera, no residual [125I] hCG binding was observed in a range of 2 pM to 10 nM.
(11) All the bone marrow chimeras as well as allophenic mice with less than 20% Fv-2ss red cells failed to develop any of the symptoms of Friend disease after infection with the polycythemic strain of Friend virus.
(12) All surviving mice were complete donor-type chimeras.
(13) Highly increased survival was obtained for [B6 lpr----B6 nu, lpr] chimeras, but not for [B6+----B6 nu, lpr] and [B6 nu----B6 nu, lpr] chimeras.
(14) In chimeras the skin grafts of both parental types survive.
(15) The affinities of the anti-chimera antibodies for the B cell epitope were assessed by a fluid-phase double-isotope radioimmunoassay.
(16) The role of stimulated T cells in the induction of B mitoses was shown by (a) the incapacity of T-depleted spleen cells to be stimulated by PHA or in primary or secondary MLC, and (b) the restoration of the mitotic response of B cells to PHA by adding to the T cell-depleted culture either a very small number of T cell (identified by their different karyotype: "in vitro chimeras") or the cell-free supernatant of a 24 hr MLC.
(17) In contrast, chimeras made by reconstituting irradiated A mice with adult spleen cells of (A X B)F1 origin generate virus-specific cytotoxic activity for infected A and B targets, suggesting that mature T cells do not change their self-specificity readily.
(18) The resulting chimera can be expressed at high levels in Escherichia coli and is readily purified.
(19) The Chimera grid was used to avoid a grid with highly skewed cells.
(20) Complicating allogeneic effects were minimized or avoided by the use of helper T cells from normal F1 hybrids, parent leads to F1 chimeras, and F1 leads to parent chimeras.
Gargoyle
Definition:
(n.) A spout projecting from the roof gutter of a building, often carved grotesquely.
Example Sentences:
(1) Their intellect is normal and they have no gargoyle-like features.
(2) Bill Nighy plays the king of the demons; Miranda Otto the gargoyle queen.
(3) beta-Mannosidase deficiency was demonstrated in fibroblasts of a girl who showed severe psychomotor retardation, bone deformities and gargoylism and recurrent skin and respiratory infections and who died at 20 years of age from bronchopneumonia.
(4) In various tissues from patients with gargoylism, deficiency of beta-galactosidase A could be demonstrated.
(5) The high level of mannose in the liver from gargoylism patients seems to indicate storage of glycopeptide, adding a new group of substances to those known to be stored in gargoylism.
(6) An autopsy case of a 19-year-old boy who had shown typical gargoyle features, strictly consistent with mucopolysaccharidosis type II (Hunter's syndrome) was reported.
(7) The reversed conditions could be caused by the difference of increased aMPS; i.e., dermatan sulfate B or heparitin sulfate in gargoylism, on the contrary, dermatan sulfate A and C or hyaluronic acid in Marfan syndrome.
(8) An adult patient with macular cherry-red spots, a gargoyle-like physical appearance, cerebellar ataxia, myoclonus, convulsive seizures, and pyramidal tract signs showed a profound deficiency of beta-galactosidase in liver and brain.
(9) The patient had a gargoyle-like face, bone change with cherry-red spot and absence of mucopolysacchariduria, and moreover accompanied by hereditary thrombocytopathy and color blindness.
(10) The nature of the basic defect in gargoylism is discussed.
(11) It must however be mentioned that the most frequent mucopolysaccharidosis, Sanfilippo's disease, and other forms of mucopolysaccharidoses (MPSoses) are not showing gargoylism.
(12) As grim as a gargoyle, craggy as a crag, jaw set in steel – even the famous smirk was well hidden behind the scowl.
(13) The present paper describes 3 out of a total of 9 siblings, aged 9, 17, and 18, with the following symptoms: gargoyle-like facial features, clouding of the cornea in both eyes, dysostosis multiplex, slightly impaired intelligence, hepatosplenomegaly, umbilical hernia, and increased secretion of mucopolysaccharides in the urine, in particular dermatan and heparan sulfate.
(14) Cellulose acetate electrophoresis differentiated clearly between the two major forms of gargoylism, the Hurler and Sanfilippo syndromes, but differentiation between the Hurler, Hunter, and Scheie syndromes was more difficult on electrophoretic data alone.
(15) The samples analyzed were obtained from control subjects, patients with gargoylism, and patients with a few other kinds of storage disorders.
(16) Studies in the morphology, histochemistry, and ultrastructure of the cerebellum, with special reference to the Purkinje cell dendrites, have been undertaken in eight cases of gargoylism.
(17) Still though, the obsession with personality, the grand gargoyles of the dugout over, say, tactics and development remains.
(18) In newspapers, cartoons squat like gargoyles on top of the columns, and while you nibble your way through the columnists' prose for several minutes, you swallow the cartoon whole in seconds.
(19) An autopsy case of a 9 years and 5 months old gargoyle girl diagnosed as Sanfilippo B syndrome by the biochemical demonstration of a large amount of heparan sulfate in urine and some organs and of deficiency of alpha-N-acetyl-D-glucosaminidase in the liver and brain was reported.
(20) A 17-year-old patient clinically manifesting gargoyle face, dwarfism, skeletal bone deformity, mild mental retardation and benign course was presented.