(n.) A colorless volatile liquid, CHCl3, having an ethereal odor and a sweetish taste, formed by treating alcohol with chlorine and an alkali. It is a powerful solvent of wax, resin, etc., and is extensively used to produce anaesthesia in surgical operations; also externally, to alleviate pain.
(v. t.) To treat with chloroform, or to place under its influence.
Example Sentences:
(1) It was readily soluble, however, in nonpolar solvents such as n-hexane and chloroform.
(2) Homogenates of these cells in chloroform-methanol solution showed an identical absorption spectrum with pure bilirubin dissolved in the same solution.
(3) Male and female DBA 11 mice recovered from 1 hr of anesthesia with chloroform of fluoroxene apparently unharmed.
(4) After introduction of surgical anesthesia with general agents such as ether and chloroform, a large number of deaths due to anesthetic toxicity were reported.
(5) One was best soluble in modified chloroform-methanol-water mixture (10:10:3) and corresponded most probably to the oligosaccharyl disphosphodolichol (oligo-PP-Dol) described to be significantly increased in LPs of inherited type.
(6) The methanol-ammonia (20:1) and chloroform-methanol-ammonia (2:2:1) systems, used with silica-gel plates, are the most promising for rapid preliminary screening of tuna fish extracts for histamine.
(7) Mice administered chloroform in corn oil displayed a significant degree of diffuse parenchymal degeneration (5 of 10 males and 1 of 10 females) and mild to moderate early cirrhosis (5 of 10 males and 9 of 10 females); significant pathological lesions were not observed in the animals administered corn oil without chloroform nor in mice receiving chloroform in 2% Emulphor.
(8) When citrate was reacted with HOCl, beta-ketoglutaric acid, monochloroacetone, dichloroacetone, and trichloroacetone were produced as reaction intermediates and chloroform as a final product.
(9) A methanol-aqueous KCl extraction is used, followed by cleanup with clarifying agents and partition into chloroform.
(10) An almost pure form of the bovine heart mitochondrial adenosine triphosphatase (ATPase) is released from the membrane by shaking submitochondrial particles with chloroform.
(11) The use of a chloroform:methanol extraction of 10 ml of fluid resulted in recoveries of at least 90% of the glycosaminoglycans, otherwise an insoluble product resulted.
(12) The primary finding was that chloroform increased the yield of renal tubular adenomas and adenocarcinomas in male rats in a dose-related manner.
(13) Three new euglobals with acylphloroglucinol-monoterpene structures, named euglobal -G1 (1), -G2 (2), and -G3 (3) were isolated from the chloroform extract of the juvenile leaves of Eucalyptus grandis (Myrtaceae).
(14) However, the concentration of endotoxin in whole blood and platelet-rich plasma could be measured with this Limulus test after lysing the platelets to release the endotoxin and subsequently removing the inhibitory proteins by chloroform precipitation.
(15) The ethanolic extract from rat liver mitochondrial membranes contains a number of highly polar complex lipids, which are found in the aqueous layer when subjected to the usual chloroform-water partition procedures.
(16) Addition of chloroform and molybdate caused an accumulation of cold acetate in large sediment cores and of [14C]acetate in small cores to which [14C]bicarbonate had been added.
(17) A variety of protected peptides up to tetradecapeptides have been chromatographed at pressures of 50 to 150 psi and obtained in analytically pure from within 2 to 4 h. With such commonly used protecting groups as N-benzyloxycarbonyl (Z), N-2-(p-biphenylyl)-2-propyloxycarbonyl (Bpoc), N-t-butyloxycarbonyl (Boc), O- and S-t-butyl (But), and S-acetamidomethyl (Acm), compounds were sufficiently soluble in chloroform, alcohols, acetic acid, or mixtures of these solvents for column loading.
(18) Both 31Si and 68Ge were water extractable (47%-74% and 38%-89%, respectively) from liver cell organelles; 45%-81% 31Si and 66%-90% 68Ge were extractable in 10% TCA, while only 10%-59% of either isotope were extractable in organic solvents (acetone, chloroform, ethanol).
(19) The mobile phase consisted of a high percentage of methanol or acetonitrile with a small amount of chloroform.
(20) Treatment of this ketone with either phenyllithium or phenylamagnesium bromide in ether at room temperature followed by solvolysis of the resulting alcohol in a mixture of trifluoroacetic acid, sodium azide, and chloroform gave a mixture of cis- and trans-3-azido-3-phenylbicyclo[3.1.0]hexanes.
Nitroform
Definition:
(n.) A nitro derivative of methane, analogous to chloroform, obtained as a colorless oily or crystalline substance, CH.(NO2)3, quite explosive, and having well-defined acid properties.
Example Sentences:
(1) The initial rate of substrate- and enzyme-dependent nitroform production was linearly related to functional active site content.
(2) The addition of n-butylamine to assay mixtures containing lysyl oxidase and TNM markedly increased the background rate of nitroform release.
(3) Isocitrate lyase of germinating castor seed endosperm catalyzes the reactions of succinate and of isocitrate (but not of glyoxylate) with tetranitromethane (TNM), giving rise to the nitroform anion (C-(NO2)3), analogous to the reaction of TNM with carbanions (O.P.
(4) The Km for n-butylamine was essentially the same whether determined from the rate of lysyl oxidase-catalyzed nitroform release or from the rate of n-butyraldehyde production in the absence of TNM, the latter assessed by measurements of the rate of H2O2 formation.