What's the difference between cinchonism and quinism?
Cinchonism
Definition:
(n.) A condition produced by the excessive or long-continued use of quinine, and marked by deafness, roaring in the ears, vertigo, etc.
Example Sentences:
(1) In all patients plasma quinine concentrations exceeded the high minimum inhibitory concentration for Plasmodium falciparum malaria prevalent in Thailand within four hours of the start of treatment but did not cause toxicity other than mild cinchonism.
(2) Cinchonism is the well-known syndrome of quinine overdose involving disturbances of vision, hearing, and balance, which has occasional importance in aviation pathology, usually related to ingestion of tonic water.
(3) Cinchonism occurred in 25% of those treated with quinine, but it was fully reversible and never necessitated withdrawal of the drug.
(4) However, the simple expedient of increasing the nightly dose of quinine may carry the concomitant risk of cinchonism.
(5) They also experienced the classic symptoms of cinchonism, including nausea, vomiting, and tinnitus.
(6) Several features are common to both an acute single overdose in self-poisoning and accumulation of quinine during therapy for malaria: together they are termed cinchonism.
(7) ; one developed cinchonism and one malaise, the remainder showing no excess toxicity compared with epirubicin alone.
(8) These reactions include GI intolerance, cardiac arrhythmias, fever with and without associated hepatic dysfunction or leukopenia, cinchonism, and hemolytic anemia.
(9) Signs of cinchonism and common ototoxins are discussed.
(10) Quinine intoxication can also cause cinchonism, which is marked by tinnitus, vertigo, blurred vision and scotomata, and possible optic atrophy or death.
(11) We conclude that quinine is highly effective in the treatment of P. falciparum infection and is mandatory if the clinical condition requires a fast-acting blood schizonticide, in cases of hyper-parasitaemia and if multi-drug resistance occurs; its use should not be restricted by reversible side-effects such as cinchonism.