(n.) A period in human life in which some great change is supposed to take place in the constitution. The critical periods are thought by some to be the years produced by multiplying 7 into the odd numbers 3, 5, 7, and 9; to which others add the 81st year.
(n.) Any critical period.
Example Sentences:
(1) The purpose of this investigation was to evaluate the relationship between climacteric status and health symptoms across age cohorts in 522 African American women aged 25-75.
(2) These data suggested that estrogen may be able to control the function of the autonomic nervous system in climacteric woman.
(3) Researchers have failed to distinguish between the spontaneous symptoms of women subject to climacteric disturbances and the sensations others admit to on questioning.
(4) The TAA component of CaCx common for all clinical stages, irrespective of climacteric states, was partially purified by subjecting postmeno CaCx, Stage II to gel filtration on Sephadex G-200.
(5) Considering in detail the results some immediate clinical and metabolic consequences come out: namely, want of Ca is prevailing in women and just in the critical age classes (20-40 and 50-59 years, that is in fertile and climacteric ages).
(6) Although the evidence is not conclusive, overall many sexual changes seem to occur in the climacteric years.
(7) The statement that the human female climacteric represents a pathologic rather than a physiologic state should not generate antagonistic counter-arguments; rather, it should be recognized as a challenge for the identification, prediction, and prevention of organic disease in the woman during the climacteric and after.
(8) It is argued that this differential recovery of fructose 2,6-bisphosphate undermines claims that the amount of this compound increases at the climacteric.
(9) It has also been shown that too low doses of ERT are able to exert therapeutical effects on some climacteric symptoms but not on bone and compounds exerting synergic actions with ERT on bone without effects on other organs could be useful.
(10) Bone mass, calcium and lipid metabolism, climacteric symptoms, bleeding, blood pressure, and weight changes were studied in 62 healthy postmenopausal women at 3-month intervals throughout 2 years of treatment with continuous estradiol valerate (2 mg) plus cyproterone acetate (1 mg), sequential estradiol valerate (2 mg) plus levonorgestrel (75 micrograms), or placebo.
(11) Risk factors (obesity, hypertension, diabetes mellitus) for endometrial cancer were found in 38% of MB and in 20% of climacteric metrorrhagia.
(12) Of climacteric disturbances should be spoken only after menopause.
(13) Climacteric symptoms and hot flushes were significantly reduced in both hormone groups compared with the placebo group.
(14) The endocrinological changes of the climacteric have been defined by studying the concentrations of follicle-stimulating hormone (FSH), luteinising hormone (LH), androstenedione, testosterone, oestrone, and oestradiol in 60 normal postmenopausal women of different menopausal ages.
(15) In climacteric syndrome in a narrow sense (i.e., dysautonomic type), each complaint may also have its specific endocrinological cause.
(16) Similarly, attitudes to the climacteric vary across cultural origins, especially with regard to husband-wife relationships.
(17) Significant changes in carbon dioxide production and oxygen consumption were still evident well into the climacteric.
(18) The selection criterion was the evidence of risk factors for endometrial carcinoma, climacteric bleedings (obesity, late menopause, high blood pressure, diabetes), or endometriotropic estrogen therapy in the postmenopause.
(19) This can be probably explained for the genital district by the hyperestrogenic situation that the climacteric woman experiences and by the promoting effect that estrogens have on the neoplastic growth.
(20) Our data imply that climacteric symptoms are not accompanied by changes in the production of prostacyclin and thromboxane A2.
Critical
Definition:
(n.) Qualified to criticise, or pass judgment upon, literary or artistic productions.
(n.) Pertaining to criticism or the critic's art; of the nature of a criticism; accurate; as, critical knowledge; a critical dissertation.
(n.) Inclined to make nice distinctions, or to exercise careful judgment and selection; exact; nicely judicious.
(n.) Inclined to criticise or find fault; fastidious; captious; censorious; exacting.
(n.) Characterized by thoroughness and a reference to principles, as becomes a critic; as, a critical analysis of a subject.
(n.) Pertaining to, or indicating, a crisis, turning point, or specially important juncture; important as regards consequences; hence, of doubtful issue; attended with risk; dangerous; as, the critical stage of a fever; a critical situation.
Example Sentences:
(1) The newborn with critical AS typically presents with severe cardiac failure and the infant with moderate failure, whereas children may be asymptomatic.
(2) The hypothesis that proteins are critical targets in free radical mediated cytolysis was tested using U937 mononuclear phagocytes as targets and iron together with hydrogen peroxide to generate radicals.
(3) The interaction of the antibody with both the bacterial and the tissue derived polysialic acids suggests that the conformational epitope critical for the interaction is formed by both classes of compounds.
(4) Ursodeoxycholate was the only dihydroxy bile salt which was able to solubilize phospholipid (although not cholesterol) below the critical micellar concentration.
(5) The pathology resulting from a missense mutation at residue 403 further suggests that a critical function of myosin is disrupted by this mutation.
(6) The criticism over the downgrading of the leader of the Lords was led by Lord Forsyth of Drumlean, a former Scotland secretary, who is a respected figure on the right.
(7) Anaerobes, in particular Bacteroides spp., are the predominant bacteria present in mixed intra-abdominal infections, yet their critical importance in the pathogenicity of these infections is not clearly defined.
(8) Even former Florida governor Jeb Bush, one of Trump’s chief critics, said ultimately, “anybody is better than Hillary Clinton”.
(9) Also critical to Mr Smith's victory was the decision over lunch of the MSF technical union's delegation to abstain on the rule changes.
(10) Critics say he is unelectable as prime minister and will never be able to implement his plans, but he has nonetheless pulled attention back to an issue that many thought had gone away for good.
(11) The high incidence of infant astigmatism has implications for critical periods in human visual development and for infant acuity.
(12) It isn't share ownership but the way people are managed that's critical.
(13) GlaxoSmithKline was unusually critical of the decision by Nice, the National Institute for Health and Clinical Excellence, and also the Scottish Medicines Consortium, to reject its drug belimumab (brand name Benlysta) in final draft guidance.
(14) The present studies indicated that the critical level at which HbCO influenced VO2 max was approximately 4.3%.
(15) Brewdog backs down over Lone Wolf pub trademark dispute Read more The fast-growing Scottish brewer, which has burnished its underdog credentials with vocal criticism of how major brewers operate , recently launched a vodka brand called Lone Wolf.
(16) Last week the WHO said the outbreak had reached a critical point, and announced a $200m (£120m) emergency fund.
(17) Critical in this understanding are the subtle changes that occur in the individual patient, reflecting the natural history of the disease or response to its treatment.
(18) That’s a criticism echoed by Democrats in the Senate, who issued a report earlier this month criticising Republicans for passing sweeping legislation in July to combat addiction , the Comprehensive Addiction and Recovery Act (Cara), but refusing to fund it.
(19) He's called out for his lack of imagination in a stinging review by a leading food critic (Oliver Platt) and - after being introduced to Twitter by his tech-savvy son (Emjay Anthony) - accidentally starts a flame war that will lead to him losing his job.
(20) Critics of wind power peddle the same old myths about investment in new energy sources adding to families' fuel bills , preferring to pick a fight with people concerned about the environment, than stand up to vested interests in the energy industry, for the hard-pressed families and pensioners being ripped off by the energy giants.