What's the difference between climacteric and perimenopause?
Climacteric
Definition:
(a.) Relating to a climacteric; critical.
(n.) A period in human life in which some great change is supposed to take place in the constitution. The critical periods are thought by some to be the years produced by multiplying 7 into the odd numbers 3, 5, 7, and 9; to which others add the 81st year.
(n.) Any critical period.
Example Sentences:
(1) The purpose of this investigation was to evaluate the relationship between climacteric status and health symptoms across age cohorts in 522 African American women aged 25-75.
(2) These data suggested that estrogen may be able to control the function of the autonomic nervous system in climacteric woman.
(3) Researchers have failed to distinguish between the spontaneous symptoms of women subject to climacteric disturbances and the sensations others admit to on questioning.
(4) The TAA component of CaCx common for all clinical stages, irrespective of climacteric states, was partially purified by subjecting postmeno CaCx, Stage II to gel filtration on Sephadex G-200.
(5) Considering in detail the results some immediate clinical and metabolic consequences come out: namely, want of Ca is prevailing in women and just in the critical age classes (20-40 and 50-59 years, that is in fertile and climacteric ages).
(6) Although the evidence is not conclusive, overall many sexual changes seem to occur in the climacteric years.
(7) The statement that the human female climacteric represents a pathologic rather than a physiologic state should not generate antagonistic counter-arguments; rather, it should be recognized as a challenge for the identification, prediction, and prevention of organic disease in the woman during the climacteric and after.
(8) It is argued that this differential recovery of fructose 2,6-bisphosphate undermines claims that the amount of this compound increases at the climacteric.
(9) It has also been shown that too low doses of ERT are able to exert therapeutical effects on some climacteric symptoms but not on bone and compounds exerting synergic actions with ERT on bone without effects on other organs could be useful.
(10) Bone mass, calcium and lipid metabolism, climacteric symptoms, bleeding, blood pressure, and weight changes were studied in 62 healthy postmenopausal women at 3-month intervals throughout 2 years of treatment with continuous estradiol valerate (2 mg) plus cyproterone acetate (1 mg), sequential estradiol valerate (2 mg) plus levonorgestrel (75 micrograms), or placebo.
(11) Risk factors (obesity, hypertension, diabetes mellitus) for endometrial cancer were found in 38% of MB and in 20% of climacteric metrorrhagia.
(12) Of climacteric disturbances should be spoken only after menopause.
(13) Climacteric symptoms and hot flushes were significantly reduced in both hormone groups compared with the placebo group.
(14) The endocrinological changes of the climacteric have been defined by studying the concentrations of follicle-stimulating hormone (FSH), luteinising hormone (LH), androstenedione, testosterone, oestrone, and oestradiol in 60 normal postmenopausal women of different menopausal ages.
(15) In climacteric syndrome in a narrow sense (i.e., dysautonomic type), each complaint may also have its specific endocrinological cause.
(16) Similarly, attitudes to the climacteric vary across cultural origins, especially with regard to husband-wife relationships.
(17) Significant changes in carbon dioxide production and oxygen consumption were still evident well into the climacteric.
(18) The selection criterion was the evidence of risk factors for endometrial carcinoma, climacteric bleedings (obesity, late menopause, high blood pressure, diabetes), or endometriotropic estrogen therapy in the postmenopause.
(19) This can be probably explained for the genital district by the hyperestrogenic situation that the climacteric woman experiences and by the promoting effect that estrogens have on the neoplastic growth.
(20) Our data imply that climacteric symptoms are not accompanied by changes in the production of prostacyclin and thromboxane A2.
Perimenopause
Definition:
Example Sentences:
(1) No significant correlations were noted between serum hormone levels during the perimenopausal period.
(2) This altered pattern of estrogen binding in perimenopausal tumors likely results from the hormonal changes of the menopausal and late premenopausal years.
(3) 147 stage II pre- and perimenopausal breast cancer patients were treated with cyclophosphamide-methotrexate-5-fluorouracil (CMF)- based adjuvant regimens.
(4) The four women with normal luteal function had castrate estrogen levels following regression of the corpus luteum, whereas one woman with an abnormal luteal phase and perimenopausal levels of gonadotropins had an agonistic response.
(5) The changes in serum concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), and progesterone (P) during menstrual cycles in a group of perimenopausal women were compared with the findings in young normal women.
(6) When comparing this type of tumors, named locally advanced cancer with inflammatory component, to other locally advanced cancers, some remarkable differences are found: there is a preponderance of younger patients, premenopausal or perimenopausal, with a greater percentage of poorly differentiated tumors and negative estrogen receptors.
(7) Controversy surrounds the optimal use of estrogen replacement therapy (ERT) for the management of vasomotor instability and other perimenopausal symptoms.
(8) The net resource costs and net health benefits of treating perimenopausal women with hormone replacement therapy were evaluated within the framework of cost-effectiveness analysis.
(9) The principal means of evaluating perimenopausal bleeding is endometrial biopsy performed in the office.
(10) All the turnover variables were measured in a group of perimenopausal women (n = 33).
(11) In the large group of patients with localized disease the association with radiation was obvious for all ages combined (irradiated RR = 3.0, not irradiated RR = 1.6), but not obvious among premenopausal (age less than 45 years) and perimenopausal (age 45-54 years) women at primary breast cancer until followed for 20 years.
(12) Sclerosing adenosis was most frequent in the perimenopausal period and had a weak association with family history of IBC.
(13) Forty-three perimenopausal women kept daily records of menstrual cycles and sexual activity.
(14) This case suggests that some perimenopausal women may respond to their own endogenous elevated gonadotropins as if they are taking ovulation-inducing drugs and may, as a consequence, form multiple follicles.
(15) Estriol (E3) and estradiol (E2) was given to 81 women with perimenopausal complaints.
(16) Epidemiologic studies have demonstrated an increase in complaints of depressed mood and other minor psychological changes from patients in the perimenopause.
(17) A perimenopausal woman presented with a calcific adnexal mass seen on abdominal radiography, surgical exploration revealed no gross evidence of metastatic disease.
(18) The exact mechanism for these totally different responses to leuprolide acetate in two perimenopausal women is not known.
(19) The literature concerning malignancy developing in extragonadal endometriosis has been reviewed and is summarized as follows: 1) 45 cases have been compiled, of which 32 were carcinomas and 13 sarcomas; 2) adenocarcinoma was the most common histologic type, although virtually every tumor of müllerian derivation has been described; 3) the typical patient was nulliparous and perimenopausal; 4) the rectovaginal septum was the most common site, and in general the frequency of malignancy in a given site parallels the frequency of endometriosis in that location; 5) simultaneous tumors of the uterus or ovary were present in seven cases (15%); 6) prognosis appeared affected by site and histologic type; 7) a history of prior pelvic irradiation to effect castration was present in three (9%) of the patients with adenocarcinoma; and 8) four (12%) of the patients with adenocarcinoma were subjected to exogenous estrogens or estrogen-secreting ovarian tumors.
(20) Many of these women are now perimenopausal and therefore entering the age of risk for ovarian neoplasia.