(n.) To stop, or fill up, as an opening; to shut; as, to close the eyes; to close a door.
(n.) To bring together the parts of; to consolidate; as, to close the ranks of an army; -- often used with up.
(n.) To bring to an end or period; to conclude; to complete; to finish; to end; to consummate; as, to close a bargain; to close a course of instruction.
(n.) To come or gather around; to inclose; to encompass; to confine.
(v. i.) To come together; to unite or coalesce, as the parts of a wound, or parts separated.
(v. i.) To end, terminate, or come to a period; as, the debate closed at six o'clock.
(v. i.) To grapple; to engage in hand-to-hand fight.
(n.) The manner of shutting; the union of parts; junction.
(n.) Conclusion; cessation; ending; end.
(n.) A grapple in wrestling.
(n.) The conclusion of a strain of music; cadence.
(n.) A double bar marking the end.
(v. t.) An inclosed place; especially, a small field or piece of land surrounded by a wall, hedge, or fence of any kind; -- specifically, the precinct of a cathedral or abbey.
(v. t.) A narrow passage leading from a street to a court, and the houses within.
(v. t.) The interest which one may have in a piece of ground, even though it is not inclosed.
(v. t.) Shut fast; closed; tight; as, a close box.
(v. t.) Narrow; confined; as, a close alley; close quarters.
(v. t.) Oppressive; without motion or ventilation; causing a feeling of lassitude; -- said of the air, weather, etc.
(v. t.) Strictly confined; carefully quarded; as, a close prisoner.
(v. t.) Out of the way observation; secluded; secret; hidden.
(v. t.) Disposed to keep secrets; secretive; reticent.
(v. t.) Having the parts near each other; dense; solid; compact; as applied to bodies; viscous; tenacious; not volatile, as applied to liquids.
(v. t.) Concise; to the point; as, close reasoning.
(v. t.) Adjoining; near; either in space; time, or thought; -- often followed by to.
(v. t.) Short; as, to cut grass or hair close.
(v. t.) Intimate; familiar; confidential.
(v. t.) Nearly equal; almost evenly balanced; as, a close vote.
(v. t.) Difficult to obtain; as, money is close.
(v. t.) Parsimonious; stingy.
(v. t.) Adhering strictly to a standard or original; exact; strict; as, a close translation.
(v. t.) Accurate; careful; precise; also, attentive; undeviating; strict; not wandering; as, a close observer.
(v. t.) Uttered with a relatively contracted opening of the mouth, as certain sounds of e and o in French, Italian, and German; -- opposed to open.
(adv.) In a close manner.
(adv.) Secretly; darkly.
Example Sentences:
(1) The presence of lactalbumin was closely associated with the presence of E.R.
(2) The suits ensures the conditions for the function of the musculoskeletal apparatus and the cardiovascular system which are close to those on the Earth.
(3) It is my desperate hope that we close out of town.” In the book, God publishes his own 'It Getteth Better' video and clarifies his original writings on homosexuality: I remember dictating these lines to Moses; and afterward looking up to find him staring at me in wide-eyed astonishment, and saying, "Thou do knowest that when the Israelites read this, they're going to lose their fucking shit, right?"
(4) However, survival was closely related to the severity of the illness at the time of randomization and was not altered by shunting.
(5) In the case of nonspecific loading highly trained individuals may have low VT values close to the level characteristic for normal subjects.
(6) When the Tunnel closed, Hardee decamped in 1991 to Up The Creek - a slightly better behaved venue in nearby Greenwich, which Hardee described as "the Tunnel with A-levels".
(7) The defensive modifications of the functions of the ego itself seen in micropsia are closely allied to those seen in the dèjá vu experience and in depersonalization.
(8) The blastocyst antiluteolytic protein therefore closely resembles the interferon-alpha family of antiviral proteins.
(9) … or a theatre and concert hall There are a total of 16 ghost stations on the Paris metro; stops that were closed or never opened.
(10) Aside from these characteristic findings of HCC, it was important to reveal the following features for the diagnosis of well differentiated type of small HCC: variable thickening or distortion of trabecular structure in association with nuclear crowding, acinar formation, selective cytoplasmic accumulation of Mallory bodies, nuclear abnormalities consisting of thickening of nucleolus, hepatic cords in close contact with bile ducts or blood vessels, and hepatocytes growing in a fibrous environment.
(11) Under resting conditions, the variance of cerebral metabolism seems to be primarily related to regions which are closely involved with the limbic system.
(12) It was concluded that the spheno-occipital complex has a close relationship to the skeletal facial pattern and contributes to the facial formation.
(13) The remaining 5 soil samples, obtained from sites that were not in close proximity to lakes, were also negative except for one that contained type B.
(14) Other recommendations for immediate action included a review of the Nursing and Midwifery Council and the General Medical Council for doctors, with possible changes to their structures; the possible transfer of powers to launch criminal prosecutions for care scandals from the Health and Safety Executive to the Care Quality Council; and a new inspection regime, which would focus more closely on how clean, safe and caring hospitals were.
(15) Of great influence on the results of measurements are preparation and registration (warm-up-time, amplification, closeness of pressure-system, unhurt catheters), factors relating to equipment and methods (air-bubbles in pressure-system, damping by filters, continuous infusion of the micro-catheter, level of zero-pressure), factors which occur during intravital measurement (pressure-drop along the arteria pulmonalis, influence of normal breathing, great intrapleural pressure changes, pressure damping in the catheter by thrombosis and external disturbances) and last not least positive and negative acceleration forces, which influence the diastolic and systolic pulmonary artery pressure.
(16) Only one part of the theory of Alajouanine and colleagues has been confirmed by our experiments for our results have shown that there is a very close correlation between semantic paraphasias and disorders of semantic differentiation whilst no correlation can be found between phonemic paraphasias and disturbances in auditory phonemic discrimination.
(17) A remarkably close relationship was found between both H. pylori urease subunits and jack bean (Canavalia ensiformis) urease, the subunit of which is a single 840 amino acid polypeptide.
(18) (2) A close correlation between the obesity index and serum GPT was recognized by elevation of the standard partial regression coefficient of serum GPT to obesity index and that of obesity index to serum GPT when the data from all 617 students was analysed in one group.
(19) The new trabecular bone closely resembled that typically seen at electrically active implants.
(20) Using polyclonal antibodies raised against yeast p34cdc2, we have detected a 36 kd immunoactive polypeptide in macronuclei which binds to Suc1 (p13)-coated beads and closely follows H1 kinase activity.
Fold
Definition:
(v. t.) To lap or lay in plaits or folds; to lay one part over another part of; to double; as, to fold cloth; to fold a letter.
(v. t.) To double or lay together, as the arms or the hands; as, he folds his arms in despair.
(v. t.) To inclose within folds or plaitings; to envelop; to infold; to clasp; to embrace.
(v. t.) To cover or wrap up; to conceal.
(v. i.) To become folded, plaited, or doubled; to close over another of the same kind; to double together; as, the leaves of the door fold.
(v.) A doubling,esp. of any flexible substance; a part laid over on another part; a plait; a plication.
(v.) Times or repetitions; -- used with numerals, chiefly in composition, to denote multiplication or increase in a geometrical ratio, the doubling, tripling, etc., of anything; as, fourfold, four times, increased in a quadruple ratio, multiplied by four.
(v.) That which is folded together, or which infolds or envelops; embrace.
(n.) An inclosure for sheep; a sheep pen.
(n.) A flock of sheep; figuratively, the Church or a church; as, Christ's fold.
(n.) A boundary; a limit.
(v. t.) To confine in a fold, as sheep.
(v. i.) To confine sheep in a fold.
Example Sentences:
(1) Patient plasma samples demonstrated evidence of marked complement activation, with 3-fold elevations of C3a desArg concentrations by the 8th day of therapy.
(2) 5-Azacytidine (I) stability was increased approximately 10-fold over its stability in water or lactated Ringer injection by the addition of excess sodium bisulfite and the maintenance of pH approximately 2.5.
(3) Radioligand binding studies revealed the presence of a single class of high-affinity (Kd = 2-6 X 10(-10) M) binding sites for ET-1 in both cells, although the maximal binding capacity of cardiac receptor was about 6- to 12-fold greater than that of vascular receptor.
(4) The enzyme was solubilized by Triton X-100 and purified approximately 480-fold by gel filtration and affinity chromatography on alanine methyl ketone-AH-Sepharose 4B.
(5) The DNA untwisting enzyme has been purified approximately 300-fold from rat liver nuclei.
(6) IP3 increased 1.7-fold and IP2 1.6-fold after 20 and 40 s, respectively.
(7) Short incubations with heparin (5 min) caused a release of the enzyme into the media, while longer incubations caused a 2-8-fold increase in net lipoprotein lipase secretion which was maximal after 2-16 h depending on cell type, and persisted for 24 h. The effect of heparin was dose-dependent and specific (it was not duplicated by other glycosaminoglycans).
(8) The following conclusions emerge: (i) when the 3' or the 3' penultimate base of the oligonucleotide mismatched an allele, no amplification product could be detected; (ii) when the mismatches were 3 and 4 bases from the 3' end of the primer, differential amplification was still observed, but only at certain concentrations of magnesium chloride; (iii) the mismatched allele can be detected in the presence of a 40-fold excess of the matched allele; (iv) primers as short as 13 nucleotides were effective; and (v) the specificity of the amplification could be overwhelmed by greatly increasing the concentration of target DNA.
(9) Epicanthal folds were present in 46%, mongoloid slanting of the lids in 72% of cases.
(10) The estimated DNA compaction ratio (approximately 3-fold) is consistent with a significant degree of nucleosome unfolding in the hyperstimulated BR genes.
(11) Two hours after refeeding rats fasted for 48 h, ODC activity increased 40-fold in mucosa from the intact jejunum and 4-fold in the mucosa of the bypassed segments.
(12) Transfection of the treated DNA into SOS-induced spheroplasts results in an increase in mutagenesis as great as 50-fold.
(13) ACh released from the vesicular fraction was about 100-fold more than could be accounted for by miniature end-plate potentials; possible causes of this overestimate are discussed.
(14) In strains completely deleted for galR, the gene which encodes the Gal repressor, the operon is derepressed by only 10-fold without an inducer.
(15) The amount of water, creatinine, electrolytes, proteins, and enzymes were higher during the day (up to three fold, p always less than 0.05), while equal amounts of amino acids were excreted in the day and the night period.
(16) TNBS reacts to an extremely small extend with hemoglobin over the concentration range 0.4 to 4 mM whereas FDNB reacts with hemoglobin to a very large extent (50 fold more than TNBS).
(17) Rates of PC in vitro metabolism by liver and kidney cytosolic cysteine conjugate beta-lyases (beta-lyases) were similar, but metabolism by renal mitochondrial beta-lyase occurred at a 3-fold higher rate than the rate obtained with hepatic mitochondrial beta-lyase.
(18) Dietary factors affect intestinal P450s markedly--iron restriction rapidly decreased intestinal P450 to beneath detectable values; selenium deficiency acted similarly but was less effective; Brussels sprouts increased intestinal AHH activity 9.8-fold, ECOD activity 3.2-fold, and P450 1.9-fold; fried meat and dietary fat significantly increased intestinal EROD activity; a vitamin A-deficient diet increased, and a vitamin A-rich diet decreased intestinal P450 activities; and excess cholesterol in the diet increased intestinal P450 activity.
(19) On the other hand, if we correct for the population of HMM with degraded light chain 2, the difference in the binding constants in the presence and absence of Ca2+ may be as great as 5-fold.
(20) The gene, which is located at chromosome XIII, is transcribed as a mRNA of about 2.7 kilobases, and the amount of message has been found to increase 3- to 4-fold during the culture.