(n.) To stop, or fill up, as an opening; to shut; as, to close the eyes; to close a door.
(n.) To bring together the parts of; to consolidate; as, to close the ranks of an army; -- often used with up.
(n.) To bring to an end or period; to conclude; to complete; to finish; to end; to consummate; as, to close a bargain; to close a course of instruction.
(n.) To come or gather around; to inclose; to encompass; to confine.
(v. i.) To come together; to unite or coalesce, as the parts of a wound, or parts separated.
(v. i.) To end, terminate, or come to a period; as, the debate closed at six o'clock.
(v. i.) To grapple; to engage in hand-to-hand fight.
(n.) The manner of shutting; the union of parts; junction.
(n.) Conclusion; cessation; ending; end.
(n.) A grapple in wrestling.
(n.) The conclusion of a strain of music; cadence.
(n.) A double bar marking the end.
(v. t.) An inclosed place; especially, a small field or piece of land surrounded by a wall, hedge, or fence of any kind; -- specifically, the precinct of a cathedral or abbey.
(v. t.) A narrow passage leading from a street to a court, and the houses within.
(v. t.) The interest which one may have in a piece of ground, even though it is not inclosed.
(v. t.) Shut fast; closed; tight; as, a close box.
(v. t.) Narrow; confined; as, a close alley; close quarters.
(v. t.) Oppressive; without motion or ventilation; causing a feeling of lassitude; -- said of the air, weather, etc.
(v. t.) Strictly confined; carefully quarded; as, a close prisoner.
(v. t.) Out of the way observation; secluded; secret; hidden.
(v. t.) Disposed to keep secrets; secretive; reticent.
(v. t.) Having the parts near each other; dense; solid; compact; as applied to bodies; viscous; tenacious; not volatile, as applied to liquids.
(v. t.) Concise; to the point; as, close reasoning.
(v. t.) Adjoining; near; either in space; time, or thought; -- often followed by to.
(v. t.) Short; as, to cut grass or hair close.
(v. t.) Intimate; familiar; confidential.
(v. t.) Nearly equal; almost evenly balanced; as, a close vote.
(v. t.) Difficult to obtain; as, money is close.
(v. t.) Parsimonious; stingy.
(v. t.) Adhering strictly to a standard or original; exact; strict; as, a close translation.
(v. t.) Accurate; careful; precise; also, attentive; undeviating; strict; not wandering; as, a close observer.
(v. t.) Uttered with a relatively contracted opening of the mouth, as certain sounds of e and o in French, Italian, and German; -- opposed to open.
(adv.) In a close manner.
(adv.) Secretly; darkly.
Example Sentences:
(1) The presence of lactalbumin was closely associated with the presence of E.R.
(2) The suits ensures the conditions for the function of the musculoskeletal apparatus and the cardiovascular system which are close to those on the Earth.
(3) It is my desperate hope that we close out of town.” In the book, God publishes his own 'It Getteth Better' video and clarifies his original writings on homosexuality: I remember dictating these lines to Moses; and afterward looking up to find him staring at me in wide-eyed astonishment, and saying, "Thou do knowest that when the Israelites read this, they're going to lose their fucking shit, right?"
(4) However, survival was closely related to the severity of the illness at the time of randomization and was not altered by shunting.
(5) In the case of nonspecific loading highly trained individuals may have low VT values close to the level characteristic for normal subjects.
(6) When the Tunnel closed, Hardee decamped in 1991 to Up The Creek - a slightly better behaved venue in nearby Greenwich, which Hardee described as "the Tunnel with A-levels".
(7) The defensive modifications of the functions of the ego itself seen in micropsia are closely allied to those seen in the dèjá vu experience and in depersonalization.
(8) The blastocyst antiluteolytic protein therefore closely resembles the interferon-alpha family of antiviral proteins.
(9) … or a theatre and concert hall There are a total of 16 ghost stations on the Paris metro; stops that were closed or never opened.
(10) Aside from these characteristic findings of HCC, it was important to reveal the following features for the diagnosis of well differentiated type of small HCC: variable thickening or distortion of trabecular structure in association with nuclear crowding, acinar formation, selective cytoplasmic accumulation of Mallory bodies, nuclear abnormalities consisting of thickening of nucleolus, hepatic cords in close contact with bile ducts or blood vessels, and hepatocytes growing in a fibrous environment.
(11) Under resting conditions, the variance of cerebral metabolism seems to be primarily related to regions which are closely involved with the limbic system.
(12) It was concluded that the spheno-occipital complex has a close relationship to the skeletal facial pattern and contributes to the facial formation.
(13) The remaining 5 soil samples, obtained from sites that were not in close proximity to lakes, were also negative except for one that contained type B.
(14) Other recommendations for immediate action included a review of the Nursing and Midwifery Council and the General Medical Council for doctors, with possible changes to their structures; the possible transfer of powers to launch criminal prosecutions for care scandals from the Health and Safety Executive to the Care Quality Council; and a new inspection regime, which would focus more closely on how clean, safe and caring hospitals were.
(15) Of great influence on the results of measurements are preparation and registration (warm-up-time, amplification, closeness of pressure-system, unhurt catheters), factors relating to equipment and methods (air-bubbles in pressure-system, damping by filters, continuous infusion of the micro-catheter, level of zero-pressure), factors which occur during intravital measurement (pressure-drop along the arteria pulmonalis, influence of normal breathing, great intrapleural pressure changes, pressure damping in the catheter by thrombosis and external disturbances) and last not least positive and negative acceleration forces, which influence the diastolic and systolic pulmonary artery pressure.
(16) Only one part of the theory of Alajouanine and colleagues has been confirmed by our experiments for our results have shown that there is a very close correlation between semantic paraphasias and disorders of semantic differentiation whilst no correlation can be found between phonemic paraphasias and disturbances in auditory phonemic discrimination.
(17) A remarkably close relationship was found between both H. pylori urease subunits and jack bean (Canavalia ensiformis) urease, the subunit of which is a single 840 amino acid polypeptide.
(18) (2) A close correlation between the obesity index and serum GPT was recognized by elevation of the standard partial regression coefficient of serum GPT to obesity index and that of obesity index to serum GPT when the data from all 617 students was analysed in one group.
(19) The new trabecular bone closely resembled that typically seen at electrically active implants.
(20) Using polyclonal antibodies raised against yeast p34cdc2, we have detected a 36 kd immunoactive polypeptide in macronuclei which binds to Suc1 (p13)-coated beads and closely follows H1 kinase activity.
Tight
Definition:
() of Tie
() p. p. of Tie.
(superl.) Firmly held together; compact; not loose or open; as, tight cloth; a tight knot.
(superl.) Close, so as not to admit the passage of a liquid or other fluid; not leaky; as, a tight ship; a tight cask; a tight room; -- often used in this sense as the second member of a compound; as, water-tight; air-tight.
(superl.) Fitting close, or too close, to the body; as, a tight coat or other garment.
(superl.) Not ragged; whole; neat; tidy.
(superl.) Close; parsimonious; saving; as, a man tight in his dealings.
(superl.) Not slack or loose; firmly stretched; taut; -- applied to a rope, chain, or the like, extended or stretched out.
(superl.) Handy; adroit; brisk.
(superl.) Somewhat intoxicated; tipsy.
(superl.) Pressing; stringent; not easy; firmly held; dear; -- said of money or the money market. Cf. Easy, 7.
(v. t.) To tighten.
Example Sentences:
(1) Freshly isolated sarcoplasmic reticulum vesicles contain 0.05 mol of tightly bound ADP and 0.03 mol of tightly bound ATP per mol of Ca2+, Mg2+-ATPase (ATP phosphohydrolase, EC 3.6.1.3).
(2) The expression of the Pgp isoforms appears to be tightly regulated and, at least in some cells, under complex hormonal control.
(3) Whereas the tight junctions of endoneurial capillaries are known to prevent certain blood-borne substances from entering the endoneurium, it was not clear whether the permeability of the pulpal capillaries, which are distant from the nerve fibres, could affect the nerve fibre environment.
(4) The cells are predominantly monopolar, tightly packed, and are flattened at the outer border of the ring.
(5) These data indicate that topoisomerase I and RNA polymerase I are tightly complexed both in vivo and in vitro, and suggest a role for DNA topoisomerase I in the transcription of ribosomal genes.
(6) Immunofluorescence and immunoelectronmicroscopy experiments demonstrated that while tight junctions demarcate PAS-O distribution in confluent cultures, apical polarity could be established at low culture densities when cells could not form tight junctions with neighboring cells.
(7) Investigations have been made to determine the identity and binding characteristics of the pterins that are bound tightly to dihydrofolate reductases which are isolated from vertebrate sources by a well established procedure.
(8) At all times, a tight inverse correlation exists between ATP and IMP concentrations.
(9) Recently, a gene for ITD (DYT1) in a non-Jewish kindred was located on chromosome 9q32-34, with tight linkage to the gene encoding gelsolin (GSN).
(10) This study investigates the use of the incentive inspirometer to observe the effects of tight versus loose clothing on inhalation volume with 17 volunteer subjects.
(11) In contrast, interchange of the histones and tightly bound non-histone protein DNA complexes from hormone-withdrawn and estrogen-stimulated chromatins during reconstitution did not affect the level of mRNAOV sequences produced.
(12) Using microelectrodes and various microscopic techniques active Na+ absorption as well as K+ secretion has been localized to the principal cells, while Cl- absorption was found to proceed largely, though not exclusively, through the tight junctions between cells.
(13) The successful establishment of a postcrisis SV-40 T antigen transformed epithelial cell line, 1HAEo-, which retains tight junctions and vectorial ion transport, is described.
(14) The present investigation shows that the intramembranous proteins of tight and gap junctions are mobile structures within the fluid membrane.
(15) In contrast, after incubation with 0.5% DOC, the core microfilaments are no longer tightly bundled yet the lateral arms remain attached with a distinct 33-nm periodicity.
(16) The data collected by several approaches reveal that assembly and maturation of vaccinia involves a tightly coupled sequence of interrelated events including the assembly of the envelope, post-translational cleavage of several virion polypeptides, and induction of the core enzymes.
(17) The tight coupling between neuronal activity and oxidative energy metabolism forms the basis for the use of cytochrome oxidase as an endogenous metabolic marker for neurons.
(18) When using a nylon thread for the attachment of a pseudophakos to the iris, it may happen that the suture is slung tightly around the implant-lens.
(19) Some antibodies and other proteins bind tightly to nitrocellulose and dissociation of these proteins by Tween 20 is barely detectable.
(20) Independent experts warn that rumours and deliberate misinformation about the regime are rife, partly because it is impossible to verify or disprove most stories about the tightly controlled country's elite.