(1) We present a mathematical model that is suitable to reconcile this apparent contradiction in the interpretation of the epidemiological data: the observed parallel time series for the spread of AIDS in groups with different risk of infection can be realized by computer simulation, if one assumes that the outbreak of full-blown AIDS only occurs if HIV and a certain infectious coagent (cofactor) CO are present.
(2) If suitable coagents are selected and used at appropriate doses, the disadvantages of each separate component (compromised blood flow to individual organs, increase in total peripheral resistance, unfavorable lipid profile for beta-blockers; stimulation of counter-regulatory mechanisms, retention of water and electrolytes for vasodilators) can be balanced.
(3) Through epidemiological considerations we conclude that full-blown AIDS may occur only if the index patient is infected by the human immunodeficiency virus (HIV) and, in addition, by some other infectious coagent.
(4) Since the dynamical behavior of the spread of AIDS cases with manifestation of Kaposi's sarcoma differs fundamentally from that of the non-Kaposi cases, we conjecture that two independent coagents (together with HIV) are responsible for the outbreak of full-blown AIDS with or without manifestation of Kaposi's sarcoma, respectively.
Cogent
Definition:
(p. a.) Compelling, in a physical sense; powerful.
(p. a.) Having the power to compel conviction or move the will; constraining; conclusive; forcible; powerful; not easily reasisted.
Example Sentences:
(1) Methods that compliment, reflect, and are consistent with developmental needs of the young teen provide cogent approaches to teen pregnancy prevention.
(2) Those concerns were most cogently expressed to Jones by his ex-boss, and former head of the CRU, Dr Tom Wigley.
(3) The court of appeal affirmed that the council had no cogent reasons to depart from the guidance.
(4) By encouraging the verbalization of cogent feelings and anxieties in a weekly group meeting, members developed a sense of mutual trust and openness.
(5) Multivariate analyses suggest that the most cogent factors affecting teenage fathering include being black, going steady, and having unorthodox views about parenting outside of marriage.
(6) The result is a cogent approach to the radiologic evaluation of the patient with a suspected umbilical remnant anomaly.
(7) It is also the most cogent organised crime syndicate in the world, trafficking – according to some estimates – up to 90% of drugs consumed in the US and varying proportions across Europe, Africa and the east.
(8) He has generally been appreciated by journalists for his accessibility and geniality – and, as Guardian readers and Thought for the Day listeners to Radio 4's Today programme know, his ability to present a coherent and challenging message cogently and to deadlines.
(9) He added: “By no stretch of the imagination can the evidence relied upon in support of the applications be described as corroborated, contemporaneous, persuasive, compelling or cogent.” It is not yet known if the officers will appeal against Meadows’s decision.
(10) The SSN says that the warning is no less cogent now than it was in 2006 and cites the developing use of unmanned drones, full body search scanners and workplace surveillance techniques to monitor employees as worrying indicators of what is to come.
(11) "Those who do not wish to listen to the informed and cogent warnings of leading scientists," he writes, "will find excuses not to do so."
(12) The most cogent evidence for a müllerian rather than a mesonephric origin for clear cell carcinoma in the female genital tract is its presence in the endometrium, a Müllerian derivative.
(13) It confirmed that local authorities should (unless they have cogent reasons not to do so) follow statutory guidance stipulating that kinship foster carers should not be paid less than unrelated foster carers simply on the basis of a familial relationship.
(14) The CBA data indicate that aging, per se, has little effect on ASR parameters; the C57 data show that hearing loss is a cogent factor.
(15) While the development-focused media has expanded, the standard for what makes a compelling blog, speech or opinion piece have not: clear writing and cogent argument backed up by solid evidence and examples.
(16) Sir Mick Jagger showed a sign of rigor mortis by refusing to serenade the burghers of Davos, but struts and frets his years upon the world's stages to little cogent effect.
(17) This guideline summarizes recommendations for (1) developing cogent procedures for diagnosis and antimicrobial susceptibility testing; (2) developing quality-control parameters for the microbiological components of clinical trials; (3) continually updating U.S. Food and Drug Administration (FDA) guidelines; (4) reviewing microbiological recommendations from other groups, such as Microbiology Subcommittees of the National Committee for Clinical Laboratory Standards; and (5) improving the microbiological aspects of FDA package inserts for antimicrobial drugs.
(18) Even 3-year-olds were able to judge real and mental entities appropriately on the basis of the 3 criteria, to sort such entities as explicitly real and not-real, and to provide cogent explanations of their choices as well.
(19) The authors concluded that nonparticipation was associated with clinically cogent adverse health outcomes, but that the magnitude of these associations varied according to the reason for nonparticipation.
(20) The purpose of the study was to identify the cogent diseases requiring hospitalization of HIV patients in the current era of PCP prophylaxis.