(superl.) Large in bulk, or composed of large parts or particles; of inferior quality or appearance; not fine in material or close in texture; gross; thick; rough; -- opposed to fine; as, coarse sand; coarse thread; coarse cloth; coarse bread.
(1) Epithelial thymoma is characterized by coarse-fiber stroma, perivascular grouping of cell elements and the lack of glycogen in them.
(2) Foveal involvement included coarse foveal granularity, thinning of the foveal retinal pigment epithelium, increasing encirclement of the fovea with focal areas of atrophy, and minimal macular drusen.
(3) In 11 of these 20 patients, visual sensitivity to detail of medium coarseness was markedly degraded, even though sensitivity to both coarse and fine detail was unimpaired.
(4) In it he translated Trump’s coarse ramblings into charming straight talk and came up with the phrase “truthful hyperbole”, which captures brilliantly an approach to business and politics in which everything is the greatest, the most beautiful.
(5) Characteristic coarse facial features and shortness of stature were observed in all cases.
(6) The pulp cavity is reduced in size with age (maturation stage), in which the characteristic three vascular layers are changed into a one-layer coarse terminal capillary network which converges directly with the main venules.
(7) (3) Their operative findings were different from ordinary Graves' goiters in that colors of the goiter were yellow-red or gray-red, surface was rough and coarse, consistency was firm, and adhesions with the adjacent connective tissue were noted.
(8) Attempts were made to purify the LH-releasing substance extracted from the leaves of Avena sativa by means of two-step chromatographic procedures using a weakly acidic ion-exchange resin (CG-50,type II) and DEAE-Sephadex A-25 (coarse) with successful results.
(9) First-time measurements of the potentially toxic inorganic species of arsenic (arsenite and arsenate) have been obtained in fine (less than 2.5 microns AD) and coarse (greater than 2.5 microns AD) atmospheric particles in the Los Angeles area.
(10) An abnormal great number of microtubules and coarsed fibers were frequently randomly scattered throughout the cytoplasmic droplet.
(11) Motorized linear slides used as micromanipulators for biological use suffer from 3 problems: vibration at low speed, poor ergonomic design of the controller and slow coarse positioning.
(12) Each antibody stained 2 populations of cortical nonpyramidal neurons: (1) A small number of large, intensely stained cells that give rise to long, coarsely beaded processes; (2) a relatively large number of small, lightly stained cells that are embedded in dense plexuses of stained punctate profiles.
(13) In the Pagalunggan subdistrict, all females used uniodised salt with 17.6% using fine salt, 20% using coarse salt and the remainder using both fine and coarse salt.
(14) Thygeson's keratitis is characterized by a coarse punctate epithelial keratitis with almost no hyperaemia of the conjunctiva.
(15) The particles selected by CYBEST as "abnormal cells" at the stage of coarse scanning were examined by direct microscopy to determine whether they were actural cells or not.
(16) Fine wrinkling, coarse wrinkling, sallowness, looseness, and hyperpigmentation were significantly improved with tretinoin therapy.
(17) Coarse, linear densities are also observed, and pleural effusion is seen in many patients.
(18) Serves 4 100g butter, at room temperature 150g flour 50g ground almonds 30g suet 1 egg yolk 50g cooked chestnuts, chopped 5 tbsp chopped fresh thyme Salt and black pepper For the leeks 1kg leeks, trimmed 100g butter Salt and pepper 200ml double cream 1 tsp nutmeg 1 To make the crumble topping, work the butter into the flour until it resembles coarse breadcrumbs, then add the ground almonds and suet.
(19) 400g cooked or tinned butterbeans 1 tsp ground cumin 10ml lemon juice ¼ clove garlic, peeled and finely minced 1 small handful picked flat-leaf parsley, finely chopped 1 tbsp plain flour (gluten-free flour also works fine) 1 tsp salt 1 egg 1 spring onion, trimmed and finely sliced 50g breadcrumbs 100g feta (or other crumbly goat's or sheep's cheese) Put the butterbeans, cumin, lemon juice, garlic, parsley, flour, salt and egg in a food processor and blitz to a coarse paste: you don't want the mix fully pureed, otherwise the burgers will be too wet and will fall apart on the grill.
(20) In women who received free-silicone injections, coarse calcifications developed in three, and gross nodularity with calcified silicone granulomas developed in one.
Crude
Definition:
(superl.) In its natural state; not cooked or prepared by fire or heat; undressed; not altered, refined, or prepared for use by any artificial process; raw; as, crude flesh.
(superl.) Unripe; not mature or perfect; immature.
(superl.) Not reduced to order or form; unfinished; not arranged or prepared; ill-considered; immature.
(superl.) Undigested; unconcocted; not brought into a form to give nourishment.
(superl.) Having, or displaying, superficial and undigested knowledge; without culture or profundity; as, a crude reasoner.
(superl.) Harsh and offensive, as a color; tawdry or in bad taste, as a combination of colors, or any design or work of art.
Example Sentences:
(1) Life expectancy and the infant mortality rate are considered more useful from an operational perspective and for comparisons than is the crude death rate because they are not influenced by age structure.
(2) While the reduced form of the "derived" polyphenolic compounds, generated during tissue homogenization, appeared to enhance dye binding with bovine serum albumin, their influence on the protein assay directly in crude homogenates was extremely diverse.
(3) Slight cross-reactivity was apparent when crude preparations of cellular or culture filtrate antigens, used in this laboratory to detect antibodies to Candida albicans, Coccidioides immitis and Cryptococcus neoformans, were probed with hyperimmune rabbit antisera to A. fumigatus.
(4) The crude survival rate at 5 years was 83.3% (age-adjusted 96%), and at 10 years 53.8%).
(5) VS had a crude topography, and receptive fields of neurons in VS were relatively large.
(6) With [125I-Tyr11]SRIF as a radiolabeled ligand, the specific ligand binding to crude membrane increased transiently in the early phase of postnatal development and then decreased.
(7) Dialyzed crude enzyme extracts from yeast cells were found to destroy diacetyl in a manner quite similar to that of diacetyl reductase from Aerobacter aerogenes, and both the bacterial and the yeast extracts were stimulated significantly by the addition of reduced nicotinamide adenine dinucleotide (NADH).
(8) A crude extract of Brucella melitensis was obtained by sonication, centrifugation and dialysis, and analyzed by quantitative immunoelectrophoresis.
(9) These results indicate that countercurrent distribution of crude extracts in aqueous two-phase systems is a useful method to study protein-protein interaction.
(10) Optimal myocyte cultures were obtained using serial 0.2% crude trypsin digestions of hearts from 1-2-day-old rats.
(11) Their defect in DNA degradation was shown not only after treatment by toluene but also in crude extracts after cell disintegration by ultrasonic and in untreated starved cultures.
(12) On subfractionation of this crude mitochondrial fraction with continuous sucrose density gradients, most of the activity of the three enzymes was found at a higher density than NAD+-isocitrate dehydrogenase and at about the same density as glutamate dehydrogenase, confirming earlier reported data for acetyl-CoA synthase.
(13) A crude membrane fraction derived from the mutant is unable to synthesize cardiolipin from phosphatidylglycerol in vitro.
(14) DNA membrane complexes from sucrose gradients, as well as the crude M-band preparation and a non-membrane-associated DNA fraction from nuclei can synthesize DNA in vitro without the addition of an external DNA template or DNA polymerase.
(15) Specificity of [125I]hCG binding to other tissues was determined by incubating crude membrane preparations of heart, skeletal muscle, liver, and kidney.
(16) Binding experiments of cyclic AMP on crude extract of dog thyroid lead to the conclusion that the maximal capacity of the specific binding site is close to the cyclic AMP content in resting thyroid cells.
(17) Interaction between these acceptor sites and crude or partially purified estradiol receptor shows a high association constant (over 10(9) M).
(18) The extent of sialomucin adjacent to a primary colorectal cancer does provide a crude assessment of tumour invasiveness and risk of local recurrence.
(19) Effects of 4-aminomethyl-1-benzylpyrrolidin-2-one-hemifumarate (WEB 1881 FU), a novel pyrrolidinone nootropic, on acetylcholine (ACh) receptors and adrenoceptors were investigated using crude membranes of the rat brain.
(20) By immunoaffinity chromatography using the immunoadsorbent, approximately 25% of crude enterotoxin applied was recovered in the eluate.