(superl.) Large in bulk, or composed of large parts or particles; of inferior quality or appearance; not fine in material or close in texture; gross; thick; rough; -- opposed to fine; as, coarse sand; coarse thread; coarse cloth; coarse bread.
(1) Epithelial thymoma is characterized by coarse-fiber stroma, perivascular grouping of cell elements and the lack of glycogen in them.
(2) Foveal involvement included coarse foveal granularity, thinning of the foveal retinal pigment epithelium, increasing encirclement of the fovea with focal areas of atrophy, and minimal macular drusen.
(3) In 11 of these 20 patients, visual sensitivity to detail of medium coarseness was markedly degraded, even though sensitivity to both coarse and fine detail was unimpaired.
(4) In it he translated Trump’s coarse ramblings into charming straight talk and came up with the phrase “truthful hyperbole”, which captures brilliantly an approach to business and politics in which everything is the greatest, the most beautiful.
(5) Characteristic coarse facial features and shortness of stature were observed in all cases.
(6) The pulp cavity is reduced in size with age (maturation stage), in which the characteristic three vascular layers are changed into a one-layer coarse terminal capillary network which converges directly with the main venules.
(7) (3) Their operative findings were different from ordinary Graves' goiters in that colors of the goiter were yellow-red or gray-red, surface was rough and coarse, consistency was firm, and adhesions with the adjacent connective tissue were noted.
(8) Attempts were made to purify the LH-releasing substance extracted from the leaves of Avena sativa by means of two-step chromatographic procedures using a weakly acidic ion-exchange resin (CG-50,type II) and DEAE-Sephadex A-25 (coarse) with successful results.
(9) First-time measurements of the potentially toxic inorganic species of arsenic (arsenite and arsenate) have been obtained in fine (less than 2.5 microns AD) and coarse (greater than 2.5 microns AD) atmospheric particles in the Los Angeles area.
(10) An abnormal great number of microtubules and coarsed fibers were frequently randomly scattered throughout the cytoplasmic droplet.
(11) Motorized linear slides used as micromanipulators for biological use suffer from 3 problems: vibration at low speed, poor ergonomic design of the controller and slow coarse positioning.
(12) Each antibody stained 2 populations of cortical nonpyramidal neurons: (1) A small number of large, intensely stained cells that give rise to long, coarsely beaded processes; (2) a relatively large number of small, lightly stained cells that are embedded in dense plexuses of stained punctate profiles.
(13) In the Pagalunggan subdistrict, all females used uniodised salt with 17.6% using fine salt, 20% using coarse salt and the remainder using both fine and coarse salt.
(14) Thygeson's keratitis is characterized by a coarse punctate epithelial keratitis with almost no hyperaemia of the conjunctiva.
(15) The particles selected by CYBEST as "abnormal cells" at the stage of coarse scanning were examined by direct microscopy to determine whether they were actural cells or not.
(16) Fine wrinkling, coarse wrinkling, sallowness, looseness, and hyperpigmentation were significantly improved with tretinoin therapy.
(17) Coarse, linear densities are also observed, and pleural effusion is seen in many patients.
(18) Serves 4 100g butter, at room temperature 150g flour 50g ground almonds 30g suet 1 egg yolk 50g cooked chestnuts, chopped 5 tbsp chopped fresh thyme Salt and black pepper For the leeks 1kg leeks, trimmed 100g butter Salt and pepper 200ml double cream 1 tsp nutmeg 1 To make the crumble topping, work the butter into the flour until it resembles coarse breadcrumbs, then add the ground almonds and suet.
(19) 400g cooked or tinned butterbeans 1 tsp ground cumin 10ml lemon juice ¼ clove garlic, peeled and finely minced 1 small handful picked flat-leaf parsley, finely chopped 1 tbsp plain flour (gluten-free flour also works fine) 1 tsp salt 1 egg 1 spring onion, trimmed and finely sliced 50g breadcrumbs 100g feta (or other crumbly goat's or sheep's cheese) Put the butterbeans, cumin, lemon juice, garlic, parsley, flour, salt and egg in a food processor and blitz to a coarse paste: you don't want the mix fully pureed, otherwise the burgers will be too wet and will fall apart on the grill.
(20) In women who received free-silicone injections, coarse calcifications developed in three, and gross nodularity with calcified silicone granulomas developed in one.
Harsh
Definition:
(a.) Rough; disagreeable; grating
(a.) disagreeable to the touch.
(a.) disagreeable to the taste.
(a.) disagreeable to the ear.
(a.) Unpleasant and repulsive to the sensibilities; austere; crabbed; morose; abusive; abusive; severe; rough.
(a.) Having violent contrasts of color, or of light and shade; lacking in harmony.
Example Sentences:
(1) Federal judges who blocked the bans cited harsh rhetoric employed by Trump on the campaign trail , specifically a pledge to ban all Muslims from entering the US and support for giving priority to Christian refugees, as being reflective of the intent behind his travel ban.
(2) The first problem facing Calderdale is sheep-rustling Happy Valley – filmed around Hebden Bridge, with its beautiful stone houses straight off the pages of the Guardian’s Lets Move To – may be filled with rolling hills and verdant pastures, but the reality of rural issues are harsh.
(3) On referral to our clinic, his physical examination and tape recording were characterized by harsh inspiratory stridor.
(4) There are harsh lessons in football and we have learned some over the last week.” Two James Milner penalties and goals from the impressive Adam Lallana, Sadio Mané and Philippe Coutinho took Liverpool’s tally to 24 in eight games.
(5) The tougher external environment in 2015 means that our businesses and functions need to work … to take a number of measures in response to the harsh trading environment,” Dudley said, according to a memo reported by Reuters.
(6) I couldn't shake the harsh words from my head and worried about if, or when, they would spill over into real life.
(7) A former senior CIA official said the secretary of state at the time, Colin Powell, eventually was informed about the program and sat in meetings in which harsh interrogation techniques were discussed.
(8) The results indicate the presence of carbohydrate epitopes buried within collagenous polypeptides that are exposed by harsh denaturing conditions.
(9) Official papers released by the National Archives show that the "wets" – notably Jim Prior, Peter Walker, Ian Gilmour, Mark Carlisle, Lord Soames and Francis Pym – were able to demonstrate that a majority of the cabinet rejected as unnecessarily harsh Sir Geoffrey Howe's demands for further public spending cuts and tax cuts.
(10) We report a case of a 17 year old boy who was referred for evaluation of a large anterior mediastinal mass, causing dyspnea and cough and resulting in a harsh systolic murmur.
(11) I appeal to the king of Saudi Arabia to exercise his power to halt the public flogging by pardoning Mr Badawi, and to urgently review this type of extraordinarily harsh penalty.” Badawi’s case was one of several recent prosecutions of activists.
(12) • Very robust questioning, known as the harsh approach, could be banned – or if not "the approach should not include an analogy with a military drill sergeant".
(13) He said he did not oppose the criminalisation of homosexuality but said imprisonment and the death penalty are too harsh.
(14) Fellow opposition activists and sympathisers took the harsh sentence as a sign that heavy jail terms awaited the rest.
(15) Pledge news: harsh • 26 Jan , Darragh MacAnthony, Peterborough chairman on the "incredibly harsh" abuse by fans of manager Mark Cooper: "Nobody has given the bloke a chance.
(16) But initial fan reaction to the first teaser trailers was harsh.
(17) The probability of skin-galvanic reaction appearance was harshly decreased.
(18) Offshore detention with increased isolation in remote and harsh circumstances exaggerates that adversity.
(19) Pictures of the concentration camps served to reinforce the necessity of the war and its unavoidably harsh economic legacy.
(20) If you're in doubt of the impact this can have, "brand imagery" studies show that when participants smoke the exact same cigarettes presented in lighter coloured packs, or in packs with "mild" in the name, they rate the smoke as lighter and less harsh, simply through the power of suggestion.