(n.) A large pebble; a rounded stone not too large to be handled; a small boulder; -- used for paving streets and for other purposes.
Example Sentences:
(1) With its steep hills and cobblestones, the neighbourhood of São Cristóvão in Ouro Preto isn’t an easy place to play football.
(2) He made his way to a spot on the cobblestones not far from the marble mausoleum housing the waxy corpse of Vladimir Lenin , and began to undress.
(3) Protesters crawl out from the tents they have pitched on the cobblestones and huddle in the cold around makeshift fires, as volunteers distribute hot tea and soup.
(4) Dehydration of walls seemingly caused the cobblestones to be transformed into two bands which continued to be separated by a channel.
(5) A 61-yr-old man with Burkitt's lymphoma who presented with 6 months of diarrhea was found, at ileoscopy, to have inflammation of the mucosal narrow lumen, deep linear ulcerations, and a "cobblestone" appearance of the terminal ileum.
(6) To the amazement of the CRS the students regrouped and fought back, overturning cars, building barricades and digging up cobblestones to use as ammunition.
(7) A 5-year-old Asian-Indian female presented with bilateral cobblestone-like peripheral lesions, a single area of chorioretinal atrophy, infero-nasal to the disc, in her right eye and a non-recordable single flash ERG.
(8) Despite the fact that these cells retain their normal cobblestone appearance, the collagen profile in each case changes over a period of 12 days in culture following confluence, the changes following distinct patterns.
(9) The cells grow with a cobblestone monolayer morphology, possess angiotensin converting enzyme activity and react with antibodies to Factor VIII antigen.
(10) Changes in the significant radiological signs in Crohn's disease, such as spicula, cobblestone pattern, stenoses and fistulas, provide information on the development of the disease and on the effect of treatment.
(11) Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of extracts prepared from retinol-treated cells which had undergone a remarkable change in shape (from a cobblestone-like to a spindle-like shape) indicated that the retinol-induced morphological change is accompanied by a marked increase of an 80-kDa protein.
(12) Two men aged respectively of 65 and 28 years presented a cobblestone appearance of the gingiva and of the tongue ("pebbly tongue"), which suggested Cowden disease.
(13) Irregular mosaics, intermediate or cobblestone structures were seen in atypical epithelium.
(14) The endothelial cells thus obtained grew to confluence as a cobblestone-like monolayer and expressed von Willebrand factor antigen.
(15) One cell type exhibited cobblestone-like appearance and remained in the center of the islets whereas the other was more loosely arranged and rapidly left the central area by migration below the cobblestone-like cells to the periphery of the islets.
(16) Endothelial cells seeded on this peptide appeared fibroblastic with many extended processes, unlike the normal cobblestone morphology observed on tissue culture plastic.
(17) Histopathologic findings and percentage of eyes affected, in decreasing order of frequency, were myopic configuration of the optic nerve head, 37.7%; posterior staphyloma, 35.4%; degenerative changes of the vitreous, 35.1%; cobblestone degeneration, 14.3%; myopic degeneration of the retina, 11.4%; retinal detachment, 11.4%; retinal pits, holes, or tears, 8.1%; subretinal neovascularization, 5.2%; lattice degeneration, 4.9%; Fuchs spot, 3.2%; and lacquer cracks, 0.6%.
(18) Although rare, these cases provide evidence that IFs in general are not essential to growth in culture, nor are the keratin-containing IFs in particular necessarily responsible for the 'cobblestone' morphology or colony-type growth pattern characteristic of cultured epithelial cells.
(19) Purity of the endothelial cell cultures from each vascular site was assessed by the contact inhibited "cobblestone" monolayer phenotype, by positive immunofluorescence for factor VIII and by angiotensin converting enzyme activity.
(20) The cells lose their usual cobblestone appearance and acquire a fibroblastic, undifferentiated morphology.
Gravel
Definition:
(n.) Small stones, or fragments of stone; very small pebbles, often intermixed with particles of sand.
(n.) A deposit of small calculous concretions in the kidneys and the urinary or gall bladder; also, the disease of which they are a symptom.
(v. t.) To cover with gravel; as, to gravel a walk.
(v. t.) To run (as a ship) upon the gravel or beach; to run aground; to cause to stick fast in gravel or sand.
(v. t.) To check or stop; to embarrass; to perplex.
(v. t.) To hurt or lame (a horse) by gravel lodged between the shoe and foot.
Example Sentences:
(1) The dogs were housed in gravel-based, outdoor pens with doghouses in a high-altitude, high-sunshine level environment.
(2) Except for the blue guard towers it is drained of colour, a grey sameness coating gravel, fences and buildings.
(3) A former showgirl from the gravel pits of Wraysbury in Berkshire, Keeler was just 19 and was staying on the estate with her friend, patron and (some said) pimp, the society osteopath Stephen Ward.
(4) I found myself skirting the wood’s perimeter, a no-go zone of the past for us, and came next to a gravel-pocked face mined by rabbits with one of the burrows crowned with the skull of an ancestor.
(5) Opening up these magnificent forests for logging is like mining the great pyramids of Egypt for road gravel," said McKim.
(6) A potholed gravel road runs to a campsite at the mouth of the Mattole river and from there you can wander south down the coast for 25 miles before you come to the next road, at Shelter Cove.
(7) On the Sabbath the fleet of earthmovers that ordinarily grind the route to Lombrum – ferrying gravel to the detention centre building site where a crew of 300 labor to finish new staff accommodation – are resting in their compound.
(8) The reactivity of soils varies widely as geological and sedimentological conditions offer typical but different environments: gravels, chalk soil, clay, salt soils, sands, cave earths are examples of this wide variety, including atmospheric and biogenetic implications.
(9) The cellar level is on the average 5.4 times higher if the cellar has partially a gravel or earth floor than if the whole cellar surface is covered with a concrete floor.
(10) But it doesn't work that way: you may have "less gravel", but most writers agree that you can only have "fewer pebbles", not "less pebbles".
(11) This biomass was computed from that of the organisms and associated naphthalene oxidation activity washed from the gravel compared with the original suspension.
(12) We can talk about "many pebbles" but not "much pebbles", "much gravel" but not "many gravel".
(13) Ultrasound detected 59 of 60 foreign bodies, including all cubes of meat embedded with gravel, cactus spine, plastic, metal, and wood.
(14) Tulisa led, and did so with panache and some beautiful gravel.
(15) This means putting a layer of bark, grass cuttings, manure, even gravel on top of the soil to trap moisture in the earth, or at least slow down evaporation.
(16) Aged 102, Bi Kidude, the gravel-voiced singer known her raucous sense of humour and her love of cigarettes, suddenly vanished from her home.
(17) Trying to solve an actual problem of enhancing the spontaneous passage of fragments, "calculous trails" and gravel in the patients who underwent remote lithotripsy the authors used the technique of local vibrotherapy in 54 postoperative patients.
(18) We are on a gravel track and have been driving for a long time.
(19) One of its largest islands is gentle-paced Brønnøya, with its apple orchards, gravel roads and beaches.
(20) Photograph: Water Literacy Foundation In Masagi’s pit-based system, permanent structures of mud, sand, soil, gravel and boulders are built, eight per acre of farmland, and partially filled with a mix of gravel and sand.