(n.) A large pebble; a rounded stone not too large to be handled; a small boulder; -- used for paving streets and for other purposes.
Example Sentences:
(1) With its steep hills and cobblestones, the neighbourhood of São Cristóvão in Ouro Preto isn’t an easy place to play football.
(2) He made his way to a spot on the cobblestones not far from the marble mausoleum housing the waxy corpse of Vladimir Lenin , and began to undress.
(3) Protesters crawl out from the tents they have pitched on the cobblestones and huddle in the cold around makeshift fires, as volunteers distribute hot tea and soup.
(4) Dehydration of walls seemingly caused the cobblestones to be transformed into two bands which continued to be separated by a channel.
(5) A 61-yr-old man with Burkitt's lymphoma who presented with 6 months of diarrhea was found, at ileoscopy, to have inflammation of the mucosal narrow lumen, deep linear ulcerations, and a "cobblestone" appearance of the terminal ileum.
(6) To the amazement of the CRS the students regrouped and fought back, overturning cars, building barricades and digging up cobblestones to use as ammunition.
(7) A 5-year-old Asian-Indian female presented with bilateral cobblestone-like peripheral lesions, a single area of chorioretinal atrophy, infero-nasal to the disc, in her right eye and a non-recordable single flash ERG.
(8) Despite the fact that these cells retain their normal cobblestone appearance, the collagen profile in each case changes over a period of 12 days in culture following confluence, the changes following distinct patterns.
(9) The cells grow with a cobblestone monolayer morphology, possess angiotensin converting enzyme activity and react with antibodies to Factor VIII antigen.
(10) Changes in the significant radiological signs in Crohn's disease, such as spicula, cobblestone pattern, stenoses and fistulas, provide information on the development of the disease and on the effect of treatment.
(11) Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of extracts prepared from retinol-treated cells which had undergone a remarkable change in shape (from a cobblestone-like to a spindle-like shape) indicated that the retinol-induced morphological change is accompanied by a marked increase of an 80-kDa protein.
(12) Two men aged respectively of 65 and 28 years presented a cobblestone appearance of the gingiva and of the tongue ("pebbly tongue"), which suggested Cowden disease.
(13) Irregular mosaics, intermediate or cobblestone structures were seen in atypical epithelium.
(14) The endothelial cells thus obtained grew to confluence as a cobblestone-like monolayer and expressed von Willebrand factor antigen.
(15) One cell type exhibited cobblestone-like appearance and remained in the center of the islets whereas the other was more loosely arranged and rapidly left the central area by migration below the cobblestone-like cells to the periphery of the islets.
(16) Endothelial cells seeded on this peptide appeared fibroblastic with many extended processes, unlike the normal cobblestone morphology observed on tissue culture plastic.
(17) Histopathologic findings and percentage of eyes affected, in decreasing order of frequency, were myopic configuration of the optic nerve head, 37.7%; posterior staphyloma, 35.4%; degenerative changes of the vitreous, 35.1%; cobblestone degeneration, 14.3%; myopic degeneration of the retina, 11.4%; retinal detachment, 11.4%; retinal pits, holes, or tears, 8.1%; subretinal neovascularization, 5.2%; lattice degeneration, 4.9%; Fuchs spot, 3.2%; and lacquer cracks, 0.6%.
(18) Although rare, these cases provide evidence that IFs in general are not essential to growth in culture, nor are the keratin-containing IFs in particular necessarily responsible for the 'cobblestone' morphology or colony-type growth pattern characteristic of cultured epithelial cells.
(19) Purity of the endothelial cell cultures from each vascular site was assessed by the contact inhibited "cobblestone" monolayer phenotype, by positive immunofluorescence for factor VIII and by angiotensin converting enzyme activity.
(20) The cells lose their usual cobblestone appearance and acquire a fibroblastic, undifferentiated morphology.
Paving
Definition:
(p. pr. & vb. n.) of Pave
(n.) The act or process of laying a pavement, or covering some place with a pavement.
(n.) A pavement.
Example Sentences:
(1) It paves the way for Iran to get nuclear weapons.” Under the deal, Iran committed to reducing the number of its centrifuges by two-thirds, capping its level of uranium enrichment well below the level needed for bomb-grade material, reducing its enriched uranium stockpile from around 10,000kg to 300kg for 15 years, and submitting to international inspections to verify its compliance.
(2) And those who hope to lead Labour now seem to be agreed on one thing: that the path back to power will be paved with talk about aspiration .
(3) The two companies have pooled their software development resources to create MeeGo, a free software platform which they reckon will pave the way for the next generation of wireless communications devices.
(4) Cameron is hoping Thursday’s EU talks over dinner will pave the way for a deal by February, allowing him to have a referendum next year.
(5) • Russia’s president, Vladimir Putin, has accepted a proposal by the German chancellor, Angel Merkel, to set up a “fact-finding mission” that would pave the way for some form of political dialogue in the crisis, according to the German government.
(6) The rest of the EU will have a chance to give its response on Friday at talks between senior officials, paving the way for EU leaders to meet in Brussels next week.
(7) Perhaps it could help pave the way for the collaboration essential to coping with climate change.
(8) Turkey has issued a decree paving the way for the conditional release of 38,000 prisoners in an apparent move to make jail space for thousands of people who have been arrested after last month’s failed coup .
(9) The gates may be open but the road to the church that calls itself a friendship and reconciliation centre is not paved with sleek cars or thronged with believers.
(10) Although E.ON has said it will not increase bills for customers before the end of 2012, fears are growing that SSE's action will pave the way for other suppliers to increase their prices.
(11) The success of Capote paved the way for bigger and more nuanced parts for Hoffman, his turn as the villain in Mission: Impossible III (2006) notwithstanding.
(12) The above-mentioned findings suggested that the Er:YAG laser could pave the way for the cavity preparation with acid-resistant cavity margin.
(13) His treatment was largely traditional and he tended to ignore contemporary advances in medical science, but his meticulous records of patients and of their response to treatment paved the way for the clinical approach which was to prevail in the future.
(14) The following year he played a philosophising, brutal hitman in the film True Romance, written by Quentin Tarantino , which paved the way for his lead role in The Sopranos, the gangster family saga that ran for six seasons from 1999.
(15) Iran's invitation to Syria talks marks significant shift for US and allies Read more Saudi Arabia, on the other hand, has insisted that Assad must go and that, in the first instance, a transitional government agreed to by the regime and the opposition should pave the way for peace.
(16) It is almost six months since Michael Grade said he would step back from the executive chairman's role, paving the way for a new chief executive.
(17) His refusal to endorse evolution hardly distinguishes him from the other Republican presidential hopefuls, but Louisiana governor Bobby Jindal can point to an unmatched achievement as he formally kicks off his campaign: signing a law that paved the way for creationism to be taught in schools.
(18) The most significant of these appointments was Philip Hammond as foreign secretary, who will pave the way for attempted reforms in the UK's relationship with the EU.
(19) But that was a clear demotion, unlike Hague whose decision to stand down at the election paved the way for a less onerous cabinet post.
(20) For his meeting with Angela Merkel and François Hollande , meant to pave the way to next month’s EU summit, the Italian prime minister Matteo Renzi chose the historical site of Ventotene, off the coast of Naples.