(n.) A powerful alkaloid, C17H21NO4, obtained from the leaves of coca. It is a bitter, white, crystalline substance, and is remarkable for producing local insensibility to pain.
Example Sentences:
(1) Altogether, 29% of the drivers had evidence of alcohol, marijuana, cocaine, prescription or nonprescription stimulants, or some combination of these, in either blood or urine.
(2) Mechanisms of drug toxicity, i.e., vascular pathology demonstrated from chronic use of cocaine.
(3) With chronic cocaine use, neurotransmitter and neuroendocrine alterations occur.
(4) In pentobarbital-anesthetized rats or in perfused hind paw of rats, the potentiation induced by cocaine and tripelennamine was more marked to norepinephrine than to epinephrine, but an inverse relation between norepinephrine and epinephrine was observed in the potentiation by I and II.
(5) The disposition of radiolabeled cocaine in humans has been studied after three routes of administration: iv injection, nasal insufflation (ni, snorting), and smoke inhalation (si).
(6) When S+ followed cocaine, stereotyped bar-pressing developed with markedly increased responding during the remainder of the session.
(7) The effects were atropine-resistant and qualitatively similar to those seen with cocaine.
(8) Knowing the risks of transporting cocaine from Africa to the US, and given the slim profit margin, “tell me who will be doing that kind of deal?” Chigbo asked.
(9) Cocaine produces simple hallucinations, PCP can produce complex hallucinations analogous to a paranoid psychosis, while LSD produces a combination of hallucinations, pseudohallucinations and illusions.
(10) Inhibition of DNA synthesis by cocaine in developing brain was not secondary to ischemia, nor to local anesthesia, as alpha-adrenergic blockade with phenoxybenzamine afforded no protection, and lidocaine could not substitute for cocaine.
(11) Cocaine, 3 microM, shifted the noradrenaline concentration response curve to the left about 0.4 log units in all renal vessel groups, thus renal vascular smooth muscle sensitivity to noradrenaline was significantly greater in vessels from rats receiving CyA than in vessels from control rats.
(12) Similarities and differences in the sensitization induced by cocaine and amphetamine (which are though to have different mechanisms of actions although common behavioral outcomes) have not been thoroughly studied.
(13) However, they do indicate that cocaine is only a weak aversion-inducing agent.
(14) Driving-under-the-influence (DUI) offenders with either alcohol- or cocaine-related problems were studied.
(15) The cardiac risk of cocaine body packing was studied by means of continuous ECG monitoring in 13 cocaine body-packers during spontaneous elimination.
(16) We present a 16-year-old with chest pain temporally related to cocaine use and discuss the relationship between cocaine use and acute myocardial infarction that has been seen in the adult population.
(17) Both acute and chronic cocaine treatments significantly increased plasma concentrations of corticosterone and reduced the ratios of 3,4-dihydroxyphenylacetic acid to dopamine and 5-hydroxyindoleacetic acid to serotonin in several brain regions.
(18) Daily cocaine injection into rodents produces a progressive increase in the motor stimulant effect of acute cocaine administration.
(19) The nine cocaine users, when compared with 14 insulin-dependent diabetics on dialysis matched by protocol, were found to be similar in terms of diabetic retinopathy and metabolic neuropathy.
(20) In view of recent reports demonstrating that illicit cocaine use may cause rhabdomyolysis, we reviewed the collective experience of a university-affiliated medical center to identify patients with cocaine-induced rhabdomyolysis.
Ecstasy
Definition:
(n.) The state of being beside one's self or rapt out of one's self; a state in which the mind is elevated above the reach of ordinary impressions, as when under the influence of overpowering emotion; an extraordinary elevation of the spirit, as when the soul, unconscious of sensible objects, is supposed to contemplate heavenly mysteries.
(n.) Excessive and overmastering joy or enthusiasm; rapture; enthusiastic delight.
(n.) Violent distraction of mind; violent emotion; excessive grief of anxiety; insanity; madness.
(n.) A state which consists in total suspension of sensibility, of voluntary motion, and largely of mental power. The body is erect and inflexible; the pulsation and breathing are not affected.
(v. t.) To fill ecstasy, or with rapture or enthusiasm.
Example Sentences:
(1) When it was grown, it would bring both ecstasy and catastrophe to women.
(2) The survey found that, among clubbers who reported having taken ecstasy within the past month, three quarters had also taken mephedrone – known in the media as "meow meow" – within the same period.
(3) West Ham, a surprising presence in the top four, were the better side and Carroll’s first goal since January was a moment of pure ecstasy for a player who has worked hard to return from the knee injury he suffered in February.
(4) She has also impressed the rank and file with her tough talking to the Police Federation, vowing to break its power and bringing to an end its closed-shop practices, sending many Tories of a certain age into ecstasies of Thatcherite nostalgia.
(5) What the last government has done, systematically, is pretend that there's a science that we need to be concerned about, with drugs like cannabis and ecstasy, which is the justification for doing what they did – making cannabis class B and keeping ecstasy class A.
(6) And ecstasy was a breakthrough, a gateway to a new way of living and being.
(7) This idea is quite contrary to the traditional view that the ancient Maya were a contemplative people, who did not indulge in ritual ecstasy.
(8) They also reported evidence from almost all regions of the world that tablets sold as ecstasy or methamphetamine contained not just the touted ingredients; they also increasingly comprised chemical cocktails that posed unforeseen public health challenges.
(9) Now we think that manufacturers have figured out a new way of making ecstasy without it.
(10) But Nutt admits that he still can't fully answer the question people really want to know, namely: "If you took a standard dose of alcohol, cocaine, heroin or ecstasy, which would be more harmful?"
(11) Celebrity use Celebrities who have admitted taking ecstasy include Oasis frontman Noel Gallagher, who claimed that taking drugs is 'like having a cup of tea', boyband star Brian Harvey and Blur's Damon Albarn.
(12) Within 12 months of his appointment he published a paper that found horse riding to be more dangerous than taking ecstasy – and probably, he suspects, triggered his dismissal nine months later.
(13) Alcohol came top, higher than heroin, crack and crystal meth, while ecstasy and LSD were ranked among the least damaging.
(14) The UK has followed US trends over cannabis, heroin and psychedelics, and led the world in the vilification of MDMA (ecstasy).
(15) She did ecstasy for the first time with, among others, psychedelic guru Timothy Leary.
(16) The primary reported effects of Ecstasy were a 'positive mood state' and feelings of intimacy and closeness to others.
(17) The result seemed assured but more drama was to come, Vaughan rifling an unstoppable shot into the top corner from the left edge of the penalty area to send Sunderland's fans and Di Canio into ecstasy.
(18) Alcohol and tobacco are more harmful than many illegal drugs, including LSD, ecstasy and cannabis, according to a paper from a drugs expert.
(19) He was sacked as head of the Home Office’s advisory council on the misuse of drugs in 2009 when he pointed out that research showed taking ecstasy was less dangerous than horseriding.
(20) That miss allowed Kolarov to redeem himself by sending in the corner that Touré volleyed past Gomes at the near post, before Agüero sent the travelling fans into ecstasy, expertly heading in Bacary Sagna’s cross.