(n.) A powerful alkaloid, C17H21NO4, obtained from the leaves of coca. It is a bitter, white, crystalline substance, and is remarkable for producing local insensibility to pain.
Example Sentences:
(1) Altogether, 29% of the drivers had evidence of alcohol, marijuana, cocaine, prescription or nonprescription stimulants, or some combination of these, in either blood or urine.
(2) Mechanisms of drug toxicity, i.e., vascular pathology demonstrated from chronic use of cocaine.
(3) With chronic cocaine use, neurotransmitter and neuroendocrine alterations occur.
(4) In pentobarbital-anesthetized rats or in perfused hind paw of rats, the potentiation induced by cocaine and tripelennamine was more marked to norepinephrine than to epinephrine, but an inverse relation between norepinephrine and epinephrine was observed in the potentiation by I and II.
(5) The disposition of radiolabeled cocaine in humans has been studied after three routes of administration: iv injection, nasal insufflation (ni, snorting), and smoke inhalation (si).
(6) When S+ followed cocaine, stereotyped bar-pressing developed with markedly increased responding during the remainder of the session.
(7) The effects were atropine-resistant and qualitatively similar to those seen with cocaine.
(8) Knowing the risks of transporting cocaine from Africa to the US, and given the slim profit margin, “tell me who will be doing that kind of deal?” Chigbo asked.
(9) Cocaine produces simple hallucinations, PCP can produce complex hallucinations analogous to a paranoid psychosis, while LSD produces a combination of hallucinations, pseudohallucinations and illusions.
(10) Inhibition of DNA synthesis by cocaine in developing brain was not secondary to ischemia, nor to local anesthesia, as alpha-adrenergic blockade with phenoxybenzamine afforded no protection, and lidocaine could not substitute for cocaine.
(11) Cocaine, 3 microM, shifted the noradrenaline concentration response curve to the left about 0.4 log units in all renal vessel groups, thus renal vascular smooth muscle sensitivity to noradrenaline was significantly greater in vessels from rats receiving CyA than in vessels from control rats.
(12) Similarities and differences in the sensitization induced by cocaine and amphetamine (which are though to have different mechanisms of actions although common behavioral outcomes) have not been thoroughly studied.
(13) However, they do indicate that cocaine is only a weak aversion-inducing agent.
(14) Driving-under-the-influence (DUI) offenders with either alcohol- or cocaine-related problems were studied.
(15) The cardiac risk of cocaine body packing was studied by means of continuous ECG monitoring in 13 cocaine body-packers during spontaneous elimination.
(16) We present a 16-year-old with chest pain temporally related to cocaine use and discuss the relationship between cocaine use and acute myocardial infarction that has been seen in the adult population.
(17) Both acute and chronic cocaine treatments significantly increased plasma concentrations of corticosterone and reduced the ratios of 3,4-dihydroxyphenylacetic acid to dopamine and 5-hydroxyindoleacetic acid to serotonin in several brain regions.
(18) Daily cocaine injection into rodents produces a progressive increase in the motor stimulant effect of acute cocaine administration.
(19) The nine cocaine users, when compared with 14 insulin-dependent diabetics on dialysis matched by protocol, were found to be similar in terms of diabetic retinopathy and metabolic neuropathy.
(20) In view of recent reports demonstrating that illicit cocaine use may cause rhabdomyolysis, we reviewed the collective experience of a university-affiliated medical center to identify patients with cocaine-induced rhabdomyolysis.
Meth
Definition:
(n.) See Meathe.
Example Sentences:
(1) The degree of increase in Meth responsiveness elicited by the initial provocation is a major factor in determining the airway response to a subsequent HS challenge.
(2) Enhanced H2O2 generation was observed in PMP activated by long-term stimulation followed by triggering with PMA, but not observed by triggering with Meth A cells.
(3) Known as crank, crystal, ice, crystal meth, and speed, MAP can be produced easily from ephedrine, and it is widely available.
(4) You are hunting for signs of the assembly of injuries - a broken nose, knocked-out teeth, fractured eye socket - incurred by falling face-first down a fire escape in Michigan while high on crystal meth, crack cocaine and cheap wine.
(5) The interaction between the MetR activator protein and the S. typhimurium metH control region was investigated.
(6) The Dyn system associated with the nucleus accumbens responded in a similar manner in that MK801 totally blocked the METH-induced increases; moreover, NMDA elevated the Dyn content in this structure.
(7) The vitamin B12 (B12)-mediated repression of the metE gene in Escherichia coli and Salmonella typhimurium requires the B12-dependent transmethylase, the metH gene product.
(8) OK-432 at a dose of 0.1, 1 or 10 KE was administered orally every 3 days or every other day for 30 days to subcutaneously Meth A tumor-inoculated mice.
(9) Like METH, single or multiple doses of either drug caused marked reductions in both tryptophan hydroxylase (TPH) activity and concentrations of 5-hydroxytryptamine (5HT) and 5-hydroxyindoleacetic acid (5HIAA) in several brain regions.
(10) As soon as I called them and was like, 'Hey guys, it's OK, I'm not smoking meth or anything,' it was OK." He adds, frowning: "I don't really know why it happened… My girlfriend told me everyone had been saying, [he puts on a sulky voice] 'Man, Mac's shows aren't crazy any more.'
(11) Tolerance in some endocrine systems appears to be quite long-lasting, as CS, TSH and PRL responses to METH challenge were still decreased 3 weeks after withdrawal from the ID regimen.
(12) The chief executive is pinning early hopes on Breaking Bad, a gritty US drama in which a chemistry teacher with terminal cancer sets up a crystal meth lab, which was barely noticed when it aired on 5USA, although for all its merits it might not exactly be classified as family entertainment.
(13) Furthermore, F-drugs could be utilized to probe the microenvironmental pH in Meth-A cells, in which the drug was located by the ratio of fluorescent intensities at 450 and 490 nm.
(14) The induction of IFN-gamma production by in vivo tumor-sensitized T cells is tumor specific, in that spleen cells from mice immunized against Meth A fibrosarcoma can produce IFN in response to irradiated Meth A cells but not in response to another syngeneic tumor M109 lung carcinoma.
(15) Splenic cells obtained from Meth-A inoculated mice which received combination therapy were not only NK-sensitive YAC-1 and LAK-sensitive EL-4 cells, but also NK-resistant Meth-A cells, as shown in a 4-h 51Cr-release assay.
(16) In this investigation, primary myocardial cell cultures were established from 3-5-day-old Sprague-Dawley rats to describe the adverse effects of Coc and Meth on the myocardium.
(17) During a raid in 2013 on a village in Guangdong province nicknamed “China’s number one drug village”, police closed dozens of secret drug labs producing meth and ketamine and confiscated at least three tonnes of drugs worth about £142m.
(18) Pharmaceutical dosage was set at approximately 30% of the increased life span (ILS) for Meth-A.
(19) No excellent antitumor effects of three platinum complexes were observed against Lewis lung carcinoma and B16 melanoma implanted s.c. even at triple injection every other day, and no effect was obtained against Meth-A fibrosarcoma under similar conditions.
(20) Eight metH mutants in Salmonella typhimurium with closely linked sites of mutation which could grow only on methionine were isolated from a metE mutant deficient in N(5)-methyltetrahydropteroyltriglutamate-homocysteine transmethylase; their deficiency in cobalamin-dependent N(5)-methyltetrahydrofolate-homocysteine transmethylase was supported by the results of enzyme studies of one of them.