(n.) A powerful alkaloid, C17H21NO4, obtained from the leaves of coca. It is a bitter, white, crystalline substance, and is remarkable for producing local insensibility to pain.
Example Sentences:
(1) Altogether, 29% of the drivers had evidence of alcohol, marijuana, cocaine, prescription or nonprescription stimulants, or some combination of these, in either blood or urine.
(2) Mechanisms of drug toxicity, i.e., vascular pathology demonstrated from chronic use of cocaine.
(3) With chronic cocaine use, neurotransmitter and neuroendocrine alterations occur.
(4) In pentobarbital-anesthetized rats or in perfused hind paw of rats, the potentiation induced by cocaine and tripelennamine was more marked to norepinephrine than to epinephrine, but an inverse relation between norepinephrine and epinephrine was observed in the potentiation by I and II.
(5) The disposition of radiolabeled cocaine in humans has been studied after three routes of administration: iv injection, nasal insufflation (ni, snorting), and smoke inhalation (si).
(6) When S+ followed cocaine, stereotyped bar-pressing developed with markedly increased responding during the remainder of the session.
(7) The effects were atropine-resistant and qualitatively similar to those seen with cocaine.
(8) Knowing the risks of transporting cocaine from Africa to the US, and given the slim profit margin, “tell me who will be doing that kind of deal?” Chigbo asked.
(9) Cocaine produces simple hallucinations, PCP can produce complex hallucinations analogous to a paranoid psychosis, while LSD produces a combination of hallucinations, pseudohallucinations and illusions.
(10) Inhibition of DNA synthesis by cocaine in developing brain was not secondary to ischemia, nor to local anesthesia, as alpha-adrenergic blockade with phenoxybenzamine afforded no protection, and lidocaine could not substitute for cocaine.
(11) Cocaine, 3 microM, shifted the noradrenaline concentration response curve to the left about 0.4 log units in all renal vessel groups, thus renal vascular smooth muscle sensitivity to noradrenaline was significantly greater in vessels from rats receiving CyA than in vessels from control rats.
(12) Similarities and differences in the sensitization induced by cocaine and amphetamine (which are though to have different mechanisms of actions although common behavioral outcomes) have not been thoroughly studied.
(13) However, they do indicate that cocaine is only a weak aversion-inducing agent.
(14) Driving-under-the-influence (DUI) offenders with either alcohol- or cocaine-related problems were studied.
(15) The cardiac risk of cocaine body packing was studied by means of continuous ECG monitoring in 13 cocaine body-packers during spontaneous elimination.
(16) We present a 16-year-old with chest pain temporally related to cocaine use and discuss the relationship between cocaine use and acute myocardial infarction that has been seen in the adult population.
(17) Both acute and chronic cocaine treatments significantly increased plasma concentrations of corticosterone and reduced the ratios of 3,4-dihydroxyphenylacetic acid to dopamine and 5-hydroxyindoleacetic acid to serotonin in several brain regions.
(18) Daily cocaine injection into rodents produces a progressive increase in the motor stimulant effect of acute cocaine administration.
(19) The nine cocaine users, when compared with 14 insulin-dependent diabetics on dialysis matched by protocol, were found to be similar in terms of diabetic retinopathy and metabolic neuropathy.
(20) In view of recent reports demonstrating that illicit cocaine use may cause rhabdomyolysis, we reviewed the collective experience of a university-affiliated medical center to identify patients with cocaine-induced rhabdomyolysis.
Slim
Definition:
(superl.) Worthless; bad.
(superl.) Weak; slight; unsubstantial; poor; as, a slim argument.
(superl.) Of small diameter or thickness in proportion to the height or length; slender; as, a slim person; a slim tree.
Example Sentences:
(1) Hopes of a breakthrough are slim, though, after WTO members failed to agree a draft deal to rubber-stamp this week.
(2) Knowing the risks of transporting cocaine from Africa to the US, and given the slim profit margin, “tell me who will be doing that kind of deal?” Chigbo asked.
(3) There are, however, plenty of arguments to be made about the Slim Reaper's supporting cast.
(4) The bank also warned it was not generating as much revenue as it expected from its corporate and institutional banking arm, the new name for its slimmed down investment banking operations.
(5) United have until Thursday to inform the FA about whether they intend to appeal but their chances of overturning the decision look slim given that the governing body has already shown the incident to a panel of three former referees.
(6) Ipso, he concluded, wants to come to this performance “armed with a slim clear book of rules and not with an iron fist”.
(7) The elongate and slim shape of the trunk provides great mass moments of inertia and that means stability against being flexed ventrally and dorsally by the forward and rearward movements of the heavy and long hindlimbs.
(8) Reagan had brilliant advisers who had a command of the issue and had a very good rapport with the key Democrats.” The prospects for a repeat look slim.
(9) He was very slim and sporty, and physically strong.
(10) He has such good body and he has really really good legs Butt… And he is slim tall and good skin."
(11) Slim margin of appreciation The third issue is that the Court is, quite rightly, determined to make sure that consistent standards of rights are upheld across the 47 member states … but at times it has felt to us in national governments that the 'margin of appreciation' – which allows for different interpretations of the Convention – has shrunk ... and that not enough account is being taken of democratic decisions by national parliaments.
(12) Only Olly Robbins, the permanent secretary to the Department for Exiting the European Union , had a slim notebook (shut) and pen.
(13) In conclusion, we can say that the slimming of very obese subjects improves blood and plasma viscosity, but the mechanism by which this improvement occurs is not the one which usually affects the determination of these rates.
(14) But last week's trading statement from Unilever confirmed that, far from cashing in on the dieting craze, Slim Fast's sales have been shrinking faster than a weight watcher's waistline.
(15) Even more welcome is the slimming-down of the syllabus in the new draft, after teachers complained about the overloading of the old one with endless facts and dates; far too many to teach in the time available in schools.
(16) That process could see Kenya’s national anti-doping agency being declared non-compliant – although insiders were keen to stress the chances of the country being removed from the Olympics were slim because the International Olympic Committee would need to kick Kenya out.
(17) Bradley Johnson went close shortly afterwards with a shot from the edge of the area that arced beyond the far post, but pickings were slim.
(18) The presence of gall stones diagnosed by ultrasonography in a cross sectional study was analysed in relation to relative weight, weight change since age 25, slimming treatment, physical activity, smoking, consumption of coffee, and diabetes mellitus.
(19) The ideal drill is a slim straight instrument, which rotates dental burrs and is operated by a light finger pressure.
(20) Costs range from £50 to hire a one-button dinner jacket and trousers or £129 for a "prom package" of slim-fit suit plus shirt and tie.