(n.) A powerful alkaloid, C17H21NO4, obtained from the leaves of coca. It is a bitter, white, crystalline substance, and is remarkable for producing local insensibility to pain.
Example Sentences:
(1) Altogether, 29% of the drivers had evidence of alcohol, marijuana, cocaine, prescription or nonprescription stimulants, or some combination of these, in either blood or urine.
(2) Mechanisms of drug toxicity, i.e., vascular pathology demonstrated from chronic use of cocaine.
(3) With chronic cocaine use, neurotransmitter and neuroendocrine alterations occur.
(4) In pentobarbital-anesthetized rats or in perfused hind paw of rats, the potentiation induced by cocaine and tripelennamine was more marked to norepinephrine than to epinephrine, but an inverse relation between norepinephrine and epinephrine was observed in the potentiation by I and II.
(5) The disposition of radiolabeled cocaine in humans has been studied after three routes of administration: iv injection, nasal insufflation (ni, snorting), and smoke inhalation (si).
(6) When S+ followed cocaine, stereotyped bar-pressing developed with markedly increased responding during the remainder of the session.
(7) The effects were atropine-resistant and qualitatively similar to those seen with cocaine.
(8) Knowing the risks of transporting cocaine from Africa to the US, and given the slim profit margin, “tell me who will be doing that kind of deal?” Chigbo asked.
(9) Cocaine produces simple hallucinations, PCP can produce complex hallucinations analogous to a paranoid psychosis, while LSD produces a combination of hallucinations, pseudohallucinations and illusions.
(10) Inhibition of DNA synthesis by cocaine in developing brain was not secondary to ischemia, nor to local anesthesia, as alpha-adrenergic blockade with phenoxybenzamine afforded no protection, and lidocaine could not substitute for cocaine.
(11) Cocaine, 3 microM, shifted the noradrenaline concentration response curve to the left about 0.4 log units in all renal vessel groups, thus renal vascular smooth muscle sensitivity to noradrenaline was significantly greater in vessels from rats receiving CyA than in vessels from control rats.
(12) Similarities and differences in the sensitization induced by cocaine and amphetamine (which are though to have different mechanisms of actions although common behavioral outcomes) have not been thoroughly studied.
(13) However, they do indicate that cocaine is only a weak aversion-inducing agent.
(14) Driving-under-the-influence (DUI) offenders with either alcohol- or cocaine-related problems were studied.
(15) The cardiac risk of cocaine body packing was studied by means of continuous ECG monitoring in 13 cocaine body-packers during spontaneous elimination.
(16) We present a 16-year-old with chest pain temporally related to cocaine use and discuss the relationship between cocaine use and acute myocardial infarction that has been seen in the adult population.
(17) Both acute and chronic cocaine treatments significantly increased plasma concentrations of corticosterone and reduced the ratios of 3,4-dihydroxyphenylacetic acid to dopamine and 5-hydroxyindoleacetic acid to serotonin in several brain regions.
(18) Daily cocaine injection into rodents produces a progressive increase in the motor stimulant effect of acute cocaine administration.
(19) The nine cocaine users, when compared with 14 insulin-dependent diabetics on dialysis matched by protocol, were found to be similar in terms of diabetic retinopathy and metabolic neuropathy.
(20) In view of recent reports demonstrating that illicit cocaine use may cause rhabdomyolysis, we reviewed the collective experience of a university-affiliated medical center to identify patients with cocaine-induced rhabdomyolysis.
Snuff
Definition:
(v. t.) The part of a candle wick charred by the flame, whether burning or not.
(v. t.) To crop the snuff of, as a candle; to take off the end of the snuff of.
(v. i.) To draw in, or to inhale, forcibly through the nose; to sniff.
(v. i.) To perceive by the nose; to scent; to smell.
(v. i.) To inhale air through the nose with violence or with noise, as do dogs and horses.
(v. i.) To turn up the nose and inhale air, as an expression of contempt; hence, to take offense.
(n.) The act of snuffing; perception by snuffing; a sniff.
(n.) Pulverized tobacco, etc., prepared to be taken into the nose; also, the amount taken at once.
(n.) Resentment, displeasure, or contempt, expressed by a snuffing of the nose.
Example Sentences:
(1) The relatively high levels of potentially carcinogenic TSNA in the saliva, together with the current popularity of snuff usage by teenagers, is of particular concern.
(2) Individual effects of tobacco on, a.o., the blood vessel supply of the oral mucosa were, thus, documented photographically every five minutes after cigarette smoking and snuff-dipping respectively in three healthy volunteers, aged 45, 35 and 30 years.
(3) The use of smokeless forms of tobacco, such as snuff and chewing tobacco, is growing at alarming rates.
(4) The dose-response relationship between pancreatic bicarbonate production and varying doses of synthetic secretin administered intravenously and in the form of snuff, was good.
(5) Twenty-nine subjects, 3 showing Degree 2 lesions, 21 Degree 3 lesions and 5 Degree 4 lesions, all of them loose snuff users were identified.
(6) These data confirm that a water-soluble extract of snuff has anti-cytolytic and anti-proliferative effects on peripheral blood lymphocytes.
(7) During the last ten years, over 900 samples of foods, snuff and other products on the Swedish market were analysed for N-nitrosamines.
(8) 184 using exclusively loose and 68 portion-bag snuff.
(9) Most of the snuff brands were rich in nitrate (greater than or equal to 1.5%), total polyphenols (greater than 2%), and in nicotine (greater than or equal to 1.5%), which is the habituating factor in tobacco use.
(10) Based on 133 cases diagnosed between 1976-1982 and 948 controls, there were significant excesses associated with use of the drug chloramphenicol (odds ratio (OR) = 5.4, 95% confidence interval (Cl) 1.2-23.9) and chewing tobacco or snuff (OR = 1.8, 95% Cl 1.1-2.9).
(11) Smokeless tobacco (chewing tobacco and snuff) contains known carcinogens shown to increase the risk for oral cancer.
(12) However, the formation of N-nitrosoproline in cigarette smokers and snuff dippers proves that smoke and snuff have a measurable potential for the endogenous formation of carcinogenic nitrosamines.
(13) It was found that 50 (81%) of the 62 questioned patients used snuff in the form of saffa.
(14) Various Indian tobacco products--cigarette, bidi, chutta and their smoke, chewing tobacco and snuff (used for inhalation as well as a dentifrice) were analysed for their content of tobacco-specific nitrosamines (N'-nitrosonornicotine, 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone and N'-nitrosoanatabine) by means of a gas chromatograph interfaced with a thermal energy analyser.
(15) After 3000 chewing strokes on each plate, the wear of the plate used while chewing snuff was significantly less compared to the plate used while chewing with nothing in the mouth.
(16) To estimate the risk of myocardial infarction in snuff users, cigarette smokers, and non-tobacco users in northern Sweden, where using snuff is traditional.
(17) Loose snuff users showed predominantly histologic Type 1 changes while portion-bag users showed more histologic Type 2 or only very discrete changes.
(18) The response of the human pancreas to varying doses of pure synthetic secretin administered intravenously and, for comparison, 8 days later in the form of snuff was examined, intraindividually, in 10 healthy test subjects.
(19) The suppression of ulcers was most evident for those groups smoking pipe or cigarettes without filter and only moderate for those using snuff.
(20) Why, it's Sepp Maier demonstrating how to use a snuff feather, of course.