What's the difference between cocculin and picrotoxin?
Cocculin
Definition:
Example Sentences:
(1) A phytochemical investigation of an ethanolic extract of the fruit of Cocculus carolinus resulted in the isolation and characterization of the alkaloids, cocculolidine and cocculine.
Picrotoxin
Definition:
(n.) A bitter white crystalline substance found in the cocculus indicus. It is a peculiar poisonous neurotic and intoxicant, and consists of a mixture of several neutral substances.
Example Sentences:
(1) Other characteristics of the LHP that were demonstrated include: a lack of blockage by GABAA receptor antagonists, a probable voltage sensitivity (decrease in amplitude in the depolarizing direction), and an apparent brief onset latency (less than 10 ms) when the early IPSP was blocked by picrotoxin.
(2) The results are interpreted as follows: picrotoxin released dopamine through disinhibition of the dopaminergic neurons as a result of blockade of gabergic receptors.
(3) This conductance increase was blocked by picrotoxin over a range of concentrations similar to those required for blockade of the GABA-induced response.
(4) Picrotoxin (50 microM) induced spontaneous bursts of repetitive spiking, followed by a slow, negative field potential, associated with spreading depression (SD), in slices from immature animals.
(5) 's are reversibly abolished by the application of picrotoxin and gamma-aminobutyric acid.
(6) The response was blocked by picrotoxin in a noncompetitive manner.
(7) However, picrotoxin and beta-guanidinopropionic acid block the response to pressure-applied GABA but do not block the response to light even at an order of magnitude higher concentration.
(8) Synchronous firing was initiated by stimulating stratum radiatum fibers in the presence of picrotoxin.
(9) The effect of baclofen was antagonized by a low dose of 4-aminopyridine (5 X 10(-6) M) whereas it was unaffected by picrotoxin (2 X 10(-5) M).
(10) 5 alpha-Pregnan-3 alpha-ol-20-one protected mice against metrazol-, bicuculline- and picrotoxin-induced seizures but not against electroshock-and strychnine-induced seizures.
(11) Putative blockers of the GABA-receptor coupled chloride channel, picrotoxin and pentylenetetrazol, and the benzodiazepine receptor antagonists Ro 15-1788 and CGS 8216 each blocked the anxiolytic effect of chlordiazepoxide.
(12) It is possible that Ro 5-4864 exerts its convulsant action at the picrotoxin site of the central Bz receptor - gamma-aminobutyric acid receptor-chloride ionophore complex.
(13) Implants containing 10% estradiol in cholesterol were less effective in protecting against picrotoxin-induced seizures.
(14) injection of hypertonic solutions of GABA and mannitol on convulsant activity and latency to reduced or enhanced depending on whether picrotoxin was given i.p.
(15) From a comparison of activation by strychnine and picrotoxin in normal and chronically decapitated embryos it was deduced that a spinal and a supraspinal component participated in their effect.
(16) The locomotion reducing effects of naloxone could be blocked by either picrotoxin or bicuculline.
(17) The GABA receptor antagonist, bicuculline, and the blockers of the GABA-receptor-coupled chloride channel, picrotoxin and pentylenetetrazol, produced a dose-dependent proconflict effect.
(18) In the second test, the cats injected with picrotoxin crossed to the other compartment while the subjects injected with saline did not move.
(19) The immediate posttraining administration of the GABA antagonist, bicuculline, or of the Cl-channel blockers, picrotoxin or Ro 5-4864, enhances memory.
(20) The action of strychnine and picrotoxin on the values of different reflex components was not identical; this pointed to a different localization of the inhibitory action of GABA and glycine in the central link of the somatosympathetic reflex arch.