(n.) One of the opium alkaloids; a white crystalline substance, C18H21NO3, similar to and regarded as a derivative of morphine, but much feebler in its action; -- called also codeia.
Example Sentences:
(1) No associations were found between sex, body-weight, smoking habits, age, urine volume or urine pH and the O-demethylation of codeine.
(2) The analgesic effects of acetaminophen alone were not significantly different from acetaminophen in combination with codeine.
(3) These results have implications in utilizing codeine phosphate as a positive skin prick test control for allergy testing.
(4) In the degradation reaction, formation of the symmetrically substituted citrate ester of codeine, 1, was found to predominate.
(5) Analysis of hair samples obtained from 10 drug-free control subjects were negative for 6-acetylmorphine, morphine, and codeine.
(6) Codeine and fenoprofen rapidly achieve their ultimate plasma equilibrium levels (on a q.
(7) Codeine 60 mg was significantly superior to placebo in all pain measures.
(8) Based on the current understanding that the analgesic effect of codeine is mediated primarily through morphine, one might anticipate that poor metabolisers would not obtain pain relief from codeine.
(9) One hundred patients completed the study and were randomly assigned to four treatment groups, each receiving either functioning transcutaneous electrical nerve stimulators (TENS), placebo TENS, acetaminophen with codeine and a functioning TENS, or acetaminophen with codeine and a placebo TENS.
(10) Codeine was converted to codeinone and 14-hydroxycodeinone.
(11) These data suggest that codeine undergoes filtration at the glomerulus, tubular secretion and passive reabsorption.
(12) The animals completely generalized to the effects of codeine, fentanyl and EK-209, but did not generalize completely to the effect of ethylketocyclazocine.
(13) Haloperidol, used in a dose which did not affect the locomotor activity of mice, completely blocked or even reversed the stimulatory action of morphine and fentanyl, and potentiated the depression of locomotor activity produced by pentazocine and codeine.
(14) Comparison of the area under the time-effect curves for the combination and the individual components confirmed the synergism between codeine and paracetamol.
(15) The hydrolysis of codeine-6-glucuronide by beta-glucuronidase was incomplete and urine reduced the extent of hydrolysis.
(16) After amphetamine, codeine, or ampicillin administration, no target organ toxicity was seen in rats or mice, even at doses which caused body weight gain depression.
(17) Codeine 60 mg had a more rapid onset of action and greater maximal effects than Ro 15-8081.
(18) Protection by codeine 20 mg, dextromethorphan 30 mg, noscapine 30 mg, and placebo against citric acid-induced cough was determined in eighteen healthy subjects.
(19) The clinical significance of this polymorphism to the antidiarrhoeal and antitussive properties of codeine is not known.
(20) These data suggest that codeine-6-glucuronide undergoes filtration at the glomerulus and tubular reabsorption.
Narcotic
Definition:
(a.) Having the properties of a narcotic; operating as a narcotic.
(n.) A drug which, in medicinal doses, generally allays morbid susceptibility, relieves pain, and produces sleep; but which, in poisonous doses, produces stupor, coma, or convulsions, and, when given in sufficient quantity, causes death. The best examples are opium (with morphine), belladonna (with atropine), and conium.
Example Sentences:
(1) The clinical usefulness of neonatal narcotic abstinence scales is reviewed, with special reference to their application in treatment.
(2) Recent research conducted by independent investigators concerning the relationship between crime and narcotic (primarily heroin) addiction has revealed a remarkable degree of consistency of findings across studies.
(3) The interactions of 3 classical alpha-adrenergic antihypertensives of prevalently central type (St 155 or clonidine St 600; BR 750 or guanabenz) with the narcotic effects of pentobarbital have been investigated in the Mus musculus.
(4) We studied the arterial blood gas determinations done on the first hospital day in 14 narcotic addicts with bacterial endocarditis (group 1) and six addicts with other medical complications of narcotic addiction (group 2).
(5) The prostaglandins A1, E1, A2, E2 and F2a were comparatively studied for their antiarrhythmic action using the model of strophanthin arrhythmia of narcotized cats.
(6) Postoperative nausea and vomiting have been associated with the use of intravenous narcotics, and nitrous oxide may worsen the emetic effects of narcotics.
(7) Though intraspinal narcotic analgesia is associated with a number of side effects, with proper knowledge these adverse reactions are wither preventable or can be greatly reduced.
(8) In this open study we reviewed the circadian distribution of extra doses of narcotic analgesics in 61 bed-ridden patients with cancer pain.
(9) In narcotized cats different respiratory reactions in acute myocardial ischemia was estimated with complicated and non-complicated ventricular fibrillation.
(10) Infants prenatally exposed to narcotics become passively addicted in-utero and may undergo neonatal abstinence at birth.
(11) Convergent results from a multimethod assessment of the issue show that methadone maintenance has long-term and short-term suppressive effects on narcotics use and property crime.
(12) The pharmacokinetics of the narcotic analgesic dextromoramide was investigated by means of a specific GC-MS method in 9 patients who were given a single oral dose of the drug (7.5 mg) together with an anticholinergic before undergoing minor orthopedic surgery.
(13) Ethanol-withdrawn animals displayed an increased sensitivity to the narcotic action of toluene.
(14) Their addiction at the time of seeking treatment was well established: narcotic drugs comprised their main daily expenditure, they had numerous problems associated with narcotic use, and high doses of methadone were necessary for detoxification.
(15) These results provide further evidence that narcotic-induced respiratory depression and analgesia are mediated by different receptor interactions.
(16) Hypericum extract enhanced the exploratory activity of mice in a foreign environment, significantly prolonged the narcotic sleeping time dose-dependently, and within a narrow dose range exhibited reserpine antagonism.
(17) In summary, there are now available very potent narcotics, with small side effect liability.
(18) This paper analyses the influence of medical professional organization on the formation of attitudes and policies toward narcotics in England.
(19) Most involved children less than 3 (42%) yr or greater than 12 (33%) yr. Products most commonly ingested included tricyclic antidepressants (22%), benzodiazepines (15%), theophylline (10%), ethanol (10%), hallucinogens (8%), salicylates (8%), narcotics (8%), antihistamines (7%), and carbamazepine (5%).
(20) In this respect the narcotic antagonist effects resemble those produced by the antiserotonin compounds or opiate agonists.