(n.) Relationship by blood; descent from the same original; kindred.
(n.) Participation of the same nature.
(n.) That tie of consanguinity which exists between persons descended from the same mother; -- used in distinction from agnation.
Example Sentences:
(1) The use of sigma 54 promoters, known to require cognate binding proteins, could allow the fine-tuning that provides the temporal ordering of flagellar gene transcription.
(2) To date, a cognate action of E2 on the GnRH pulse generator has not been described.
(3) Cognate sites in genomes that diverged approximately 100 million years ago can be detected by PCR assays based on primer pairs from unique sequences.
(4) Cognate heat shock proteins might be involved in this renaturation process.
(5) LEW rats immunized with each of the three DA MHC chains produced alloantibodies to these chains, suggesting that indirect allorecognition did occur, because of the requirement for cognate recognition of B cells by T helper cells.
(6) Microcultures of helper T (Th) cells and a few appropriately primed murine B cells can be used to detect cognate T-B interactions which lead to clonal production of IgM, IgG1, and IgE.
(7) We have investigated the structural relationship of heat-inducible and cognate members of the human hsp70 gene family.
(8) If protein mixtures are subjected to affinity elution the cognate pair [tRNAPhe-phenylalanyl-tRNA synthetase] is eluted first, followed by noncognate pairs.
(9) These results suggest that cognate T-B cell interactions may be important in the development of IgE immune responses in the normal host.
(10) Ribosomes programmed by different synonymous codons also differ in discriminating among near-cognate aminoacylated tRNAs.
(11) These results were then compared with CVB-specific IgM levels in the cognate patient sera.
(12) This line induces proliferation of and Ig secretion by I-Ak expressing but not H-2d resting and activated B cells as a result of cognate interactions.
(13) The protein has been designated as a stress cognate protein based on previous studies and data presented herein that this protein cross-reacted with a monoclonal antibody originally raised against the Drosophila 70 kilodalton heat shock protein.
(14) By radioactive in situ hybridization (ISH) using a fragment from the murine Pax-1 paired box that is almost identical to the respective sequences from the cognate human gene HuP48 and fluorescence in situ hybridization (FISH) using a complete mouse Pax-1 cDNA, we have assigned the human homologue of murine Pax-1, the PAX1 locus, to chromosome 20p.
(15) One region in most sigma factors makes sequence-specific contacts at the -10 region of its cognate promoters.
(16) This suggests that the SRE and its cognate protein are likely to be involved in the regulation of Krox-24 and presumably of other immediate-early serum response genes.
(17) A third Slp gene exists within this locus whose recombinant cognate did not express in L cells.
(18) Two of the hox appear to be cognates of the human Hu-1 (or mouse Hox 2.1) and the mouse Hox 1-3, while another is closely related to the mouse Hox 1-4.
(19) Comparison of our skeletal muscle translocator sequence with that of a recently published human fibroblast translocator cognate revealed that the two proteins are 88% identical and diverged about 275 million years ago.
(20) Comparison of the nucleotide and deduced amino acid sequence of this genome segment with cognate segments of isolates of BTV 1 from Australia and South Africa, and BTV 10 and BTV 17 from the United States, revealed homologies of 98%, 80%, 79%, and 79%, respectively, at the nucleotide level and 98%, 90%, 89%, and 90% identity, respectively, at the amino acid level.
Consanguinity
Definition:
(n.) The relation of persons by blood, in distinction from affinity or relation by marriage; blood relationship; as, lineal consanguinity; collateral consanguinity.
Example Sentences:
(1) Legislation governing adoption has attempted to make the adoptive family the equivalent of a consanguinal one, with varying degrees of success.
(2) Two strikingly similar brothers issued from consanguineous parents in the second degree present the following patterns of anomalies: retardation of growth, mental deficiency, ocular abnormalities, pectus excavatum and camptodactyly.
(3) Parental consanguinity suggests that an autosomal recessive mutation is the likely aetiology.
(4) Any patient with a fairly symmetrical 'quiet' eye disease, especially if congenital, should be suspected of having an hereditary disease--presumably due to a recessive gene, even if the parents are not consanguineous, but possibly due to a mutation which could prove dominant; a search of the literature in such cases is useful.
(5) Taking advantage of the availability of an archive of consanguineous marriages that gives accurate estimates of consanguinity in Italy, it has been possible to calculate the increase of first- and second-cousin marriages among 624 couples of cystic fibrosis (CF) parents over the general population.
(6) Consanguinity of the kindreds could not be established.
(7) In this case, lower fertility might be expected in consanguineous marriages, only because of a higher probability of homozygosis of deleterious genes.
(8) The differences between consanguineous and non-consanguineous marriages in terms of total foetal loss, perinatal, neonatal, postneonatl and infant mortality rates showed only marginal differences that attain statistical significance only because of the large sample size involved.
(9) Two subjects (brother and sister), children of consanguineous parents, showed a typical congenital corneal dystrophy associated with mental retardation and a bilateral malformation of the little finger.
(10) Impaired IL-2 activity was found in 15 of the 29 consanguineous relatives.
(11) Parental consanguinity in those with genetically determined causes of visual impairment was high compared with those with nongenetic causes (79% vs 33.3%, P < .05).
(12) Three sibs, a boy and two girls, born to Moroccan consanguineous parents, were affected with a syndrome characterized by brittle hair, mental retardation, short stature, ataxia, and gonadal dysfunction.
(13) The mores that encouraged consanguineous marriages had the lowest final lethal-gene frequencies.
(14) The comparison between 1,302 adults born from consanguineous marriages underlines a heavy depression of mental abilities.
(15) In XIX century generations consanguinity was very low (alpha coefficient 7 x 10(-5) which may be explained by the exogamic tradition of the population; this acted as a factor opposed to random drift.
(16) There was no significant difference in the prevalence of congenital malformations between Hindus (2.0%) and Muslims (2.7%) but amongst Muslims with consanguinity the prevalence of congenital malformation was 4.6 per cent compared to 2.3 per cent in non-consanguineous Muslim spouses (P less than 0.05).
(17) Consanguineous marriages are strongly favoured among the peoples of South India.
(18) The gene frequency was only 7-9.10 minus 5, but the consanguinity rate was high in the families observed.
(19) Three cases of cleidocranial dysostosis from two unrelated consanguineous families are reported.
(20) Because the parents of the siblings are consanguineous, this is probably a genetically determined condition with an autosomal recessive type of transmission.