What's the difference between coinheritance and inheritance?
Coinheritance
Definition:
(n.) Joint inheritance.
Example Sentences:
(1) When the biochemical defect is unknown, a gene can be located only through molecular approaches based on coinheritance (genetic linkage) of the disease phenotype with a particular allele of a polymorphic DNA marker that has already been mapped to a specific chromosomal region.
(2) Coinheritance of these defects apparently produced severe hypercholesterolemia in the offspring.
(3) Formal linkage analysis was applied to test for coinheritance of disease with the HLA locus within families.
(4) This suggests that a single genetic mutation that usually has a recessive effect on lipoprotein metabolism can have an interactive effect on lipid phenotype when it is coinherited with a single mutation at another gene whose product affects the same metabolic pathway.
(5) The significance of the linkage detected between the disease locus and polymorphic loci was assessed by calculating a lod score (the logarithm of the probability of observing coinheritance of two loci, assuming that they are genetically linked, divided by the probability of detecting coinheritance if they are unlinked).
(6) Linkage studies have indicated that the coinheritance frequencies are less than would be expected from the published molecular weight of E79 deoxyribonucleic acid (120 X 10(6).
(7) The variable levels of HbF in sickle cell anemia reflect the heterogeneous genetic mix of the beta s-gene-cluster haplotypes and coinheritance of alpha-thalassemia-2 in American SS patients.
(8) Mapping of tox markers was accomplished by scoring for the frequency of coinheritance of the donor tox allele with selected and unselected donor markers.
(9) The findings suggest coinheritance of high blood cholesterol and increased susceptibility to CHD.
(10) Coinheritance analysis demonstrated that five of the other transformants harbored a 100-kb segment of the cloned human insert.
(11) Coinheritance of these disorders with other beta chain hemoglobinopathies, such as beta thalassemia and the sickle cell (beta s) gene, can result in attenuation of the clinical severity of these hemoglobinopathies owing to the increased Hb F levels.
(12) Phenytoin pharmacokinetics exhibit large intersubject differences and coinheritance of phenytoin metabolism with known drug hydroxylation polymorphisms was therefore suspected.
(13) This occurred after coinheritance of alpha+ thalassaemia and APKD, which resulted in an altered band size for the (+) RsaI restriction fragment length polymorphism.
(14) The n locus is closely linked to the other six defined loci in the heavy chain chromosomal region and the allelic alternatives for each of the seven loci are coinherited by gene combinations called allogroups.
(15) From coinheritance analysis of the ERCC-3 region in independent transformants, we deduce that the gene has a size of 35 to 45 kilobases, of which one essential segment has so far been refractory to cloning.
(16) Further modulation of the clinical course by the coinheritance of alpha-thalassemia-2 tends to decrease the risk of soft tissue organ failure but increases the risk of osteonecrosis.
(17) When the coinheritance of alpha thalassaemia is suspected, it is necessary to examine carefully the red blood cell distribution of a placental sample, so that the presence of a population of fetal red blood cells is not missed.
(18) The coinheritance of alpha-thalassemia-2 further decreases the risk of major morbidity of the soft tissues but increases the risk of avascular necrosis of the bony skeleton.
(19) Determinants recognized to date as able to produce mild forms of beta-thalassemias, are beta-thalassemia mutations with a high residual output of beta-globin chain production, coinheritance of alpha-thalassemia or nondeletion HPFH linked or not linked to the beta-globin gene cluster, delta beta thalassemias and specific beta-globin haplotype.
(20) The coinheritance of alpha-thalassemia (alpha-thal) and sickle cell anemia provides a most interesting example of how separate globin gene mutations influence clinical manifestations of abnormal gene expression.
Inheritance
Definition:
(n.) The act or state of inheriting; as, the inheritance of an estate; the inheritance of mental or physical qualities.
(n.) That which is or may be inherited; that which is derived by an heir from an ancestor or other person; a heritage; a possession which passes by descent.
(n.) A permanent or valuable possession or blessing, esp. one received by gift or without purchase; a benefaction.
(n.) Possession; ownership; acquisition.
(n.) Transmission and reception by animal or plant generation.
(n.) A perpetual or continuing right which a man and his heirs have to an estate; an estate which a man has by descent as heir to another, or which he may transmit to another as his heir; an estate derived from an ancestor to an heir in course of law.
Example Sentences:
(1) Alleles in this region can be exchanged between X and Y chromosomes and are therefore inherited as if autosomal.
(2) Seven males have been observed carrying both inherited tritan and red-green defects.
(3) Pedigree studies have suggested that there may be an inherited predisposition to many apparently nonfamilial colorectal cancers and a genetic model of tumorigenesis in common colorectal cancer has been proposed that includes the activation of dominantly acting oncogenes and the inactivation of growth suppressor genes.
(4) In neither case has a significant elevation in inherited genetic effects or cancer been detected in the offspring of exposed individuals.
(5) When power-transformed scores are used to eliminate skewness, there is evidence for one distribution and it is not possible to distinguish single gene from multifactorial (polygenic or cultural) inheritance.
(6) Asymptomatic relatives that have inherited the disease probably can be detected with this method.
(7) This recently reported inherited syndrome should be recognized by pathologists because of major risk of cardiac myxoma.
(8) This situation highlights the potential importance of molecules with different inheritance patterns in elucidating complex cases of reticulate evolution.
(9) Approximately 20 inherited disorders of kidney transport occurring in man have so far been defined.
(10) Neurospora crassa mitochondrial deoxyribonucleic acid shows strict uniparental inheritance in sexual crosses, with a notable absence of mixtures and recombinant types that appear frequently in heteroplasmons.
(11) The overall results indicate an inherited impairment of 3-HSD activity confined only to C-21 steroid substrates and, thus, suggest the existence of at least two 3-HSD isoenzymes under independent genetic regulation.
(12) About one out of three profoundly deaf children has an autosomal recessive form of inherited deafness.
(13) In considering nutrition and circadian rhythms, time-of-eating behavior is an inherited, genetically controlled pattern that can be phase-shifted by conditioning or training.
(14) Given the financial crisis this government inherited, we had no choice but to make significant savings.
(15) The pupils at the Royal Blind School, Edinburgh, were surveyed and it was found that 40% of the 100 pupils had definitely inherited severe eye disease.
(16) However, as the males have not reproduced, it is not possible to rule out X-linked dominant inheritance.
(17) However, family members born at 50% risk can find out if they have inherited the mutant gene only if family analyses are possible.
(18) Proposed models for the inheritance of locus-specific methylation phenotypes in somatic cells include those in which there is stable inheritance of a methylation pattern such that all cells contain a similarly methylated locus, as well as models in which the inheritance of methylation can be variable.
(19) It inherited an economy that was growing quite strongly but activity came to an abrupt halt last autumn and has flatlined ever since.
(20) An autosomal recessive mode of inheritance of this deficiency was found.