(n.) A powerful vegetable alkaloid, C17H19NO5, extracted from the Colchicum autumnale, or meadow saffron, as a white or yellowish amorphous powder, with a harsh, bitter taste; -- called also colchicia.
Example Sentences:
(1) MAF-G activity was inhibited by mitomycin C and colchicine, which inhibit DNA synthesis and mitosis, respectively, but not by 2-deoxy-D-glucose, an inhibitor of glucose metabolism.
(2) In addition, lightly immunostained cells were distinguished in the caudal portion of the hypothalamic arcuate nucleus, area of tuber cinereum, retrochiasmatic area, and rostral portion of the paraventricular thalamic nucleus after colchicine treatment.
(3) Patients were divided into the following groups: control (followed without specific active treatment), corticosteroid group, azathioprine group, corticosteroid and azathioprine group, chlorambucil group, 5-fluorouracil group, colchicine group and isoprinosine group.
(4) The pHi response induced by the hyperosmotic stress was abolished by two calmodulin inhibitors, W-7 and chlorpromazine (50% inhibition, Ki at 28 and 20 microM, respectively), 20 microM cytochalasin B, but not by 10 microM colchicine.
(5) The increase in human leukocyte adenosine 3':5'-cyclic monophosphate (cyclic AMP) levels seen in response to various substances was markedly potentiated by colchicine and other agents that affect microtubule assembly.
(6) Radioautographic studies of absorptive cells showed that colchicine and nocodazole inhibited labelling of the microvillous border by 67% and 87%, while labelling of the basolateral plasma membrane increased by 114% and 275%.
(7) Pretreatment of the cells with colchicin abolishes the enhancing effect.
(8) The effect of intracerebroventricular injection of the mitosis inhibitor colchicine on expression of mRNA for nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin 3 was studied in the rat brain with in situ hybridization.
(9) Colchicine, which substantially enhanced capping, had no effect on calcium mobilization.
(10) Circulating fibrin was found in patients with FMF in absence of clinical manifestation of thrombosis and was statistically less frequently observed in patients treated with colchicine.
(11) Drugs such as sodium azide, cytochalasin B, colchicine, vinpocetine, and vincristine sulfate reduce binding to the antigen.
(12) No recurrence of synovitis occurred after surgical excision and colchicine therapy but arthralgia persisted.
(13) The resistant strains exhibited cross resistance to anthracycline antibiotics, vinca alkaloids, actinomycin D, colchicine.
(14) Studies of binding and uptake of tritiated colchicine suggested that drug resistance of 3T3r cells might reflect decreased uptake of drug without decreased binding to surface receptors.
(15) We tested nine (cadmium chloride, chloral hydrate, colchicine, diazepam, econazole nitrate, hydroquinone, pyrimethamine, thiabendazole, thimerosal) of the 10 known or suspected spindle poisons of the coordinated programme to study aneuploidy induction sponsored by the Commission of the European Communities using Saccharomyces cerevisiae D61.M (mitotic chromosomal malsegregation system).
(16) There was also local reduction in choline acetyltransferase (ChAT) activity and significant losses of 55-kDa protein in the soluble fraction and of 50-kDa protein in myelin and synaptosomal fractions in the hippocampi of colchicine-lesioned rats.
(17) Treatment of the acute phase in which ample use is made of colchicine must be followed by medical and dietary treatment of the chronic condition.
(18) However, preliminary results from a randomized placebo-controlled clinical trial suggest that low dose colchicine (0.6 mg twice a day orally) does not prevent restenosis.
(19) The recent discovery that an age-old drug, colchicine, can control this enigmatic, often unrecognized, recurrent disease means that most affected individuals can now lead virtually normal lives.
(20) After an intraventricular colchicine administration, NPY was found in many AVP-deficient non-oxytocinergic magnocellular neurons of the paraventricular and supraoptic nuclei in BB rats, but not in suprachiasmatic nucleus neurons.
Gout
Definition:
(n.) A drop; a clot or coagulation.
(n.) A constitutional disease, occurring by paroxysms. It consists in an inflammation of the fibrous and ligamentous parts of the joints, and almost always attacks first the great toe, next the smaller joints, after which it may attack the greater articulations. It is attended with various sympathetic phenomena, particularly in the digestive organs. It may also attack internal organs, as the stomach, the intestines, etc.
(n.) A disease of cornstalks. See Corn fly, under Corn.
(n.) Taste; relish.
Example Sentences:
(1) In 8 patients with gout and 11 patients with pseudogout synovial fluid and small tissue specimens could be obtained with the aid of the Parker-Pearson needle.
(2) Both patients are likely to be sporadic cases of familial nephropathy with gout, an autosomal dominant disease, due to a new mutation.
(3) Conversely, crystalline protein binding may be a critical factor in the pathogenesis of gout, and the presence of abnormal proteins in RA could protect against gout.
(4) Tissue degeneration in gout clearly follows (tophaceous) crystal deposition.
(5) Five of our 7 patients had a positive family history of tics, and 2 a confirmed family history of gout.
(6) A 30-year-old man had a recurrent painful calf swelling associated with gout that mimicked thrombophlebitis and possibly muscle tear.
(7) Sclerosed areas with scarce and plump villi as well as sometimes hyperplastic and polymorphous synovial cell layers could be demonstrated histologically in the tissue specimens of the needle biopsies in cases with gout.
(8) Significantly more treated patients than control subjects showed evidence of a high serum creatinine level, mild hypokalemia, and gout.
(9) A many-year investigation of 254 primary gout patients aged 21 to 78 was carried out to reveal characteristic features of a course of gout under present-day conditions.
(10) The history of saturnine gout is almost as old as civilization itself.
(11) Intra- as well as extracellular crystals could also be demonstrated with the aid of scanning electron microscopy in sediments of synovial fluid in gout and pseudogout.
(12) A study of the level of beta 2-microglobulin (beta 2-MG) in the blood serum and urine was conducted in 67 patients: 22 with chronic pyelonephritis, 13 with gout with renal lesion, 25 with chronic glomerulonephritis (5 without hyperuricemia, 20 with hyperuricemia) and 7 with amyloidosis accompanied mainly by renal lesion.
(13) Naproxen is a useful alternative agent for the treatment of acute gout.
(14) A 65-year-old man with gout and renal dysfunction had taken 1 mg of colchicine daily for 3 years.
(15) In 1988 Abbot could prove that among men, those afflicted by gout as compared to those without gout experienced a 60% excess of coronary heart disease.
(16) The authors presented the results of a 5-year follow-up of 50 gout patients who had been regularly (no less than 3-4 times a year) examined in outpatient clinics.
(17) A high prevalence of gout among workers of the mining industry and early age at the onset of disease suggest probable association of gout with some industrial factors (manganese, tungsten, molybdenum, bismuth).
(18) For the great majority of patients with uncomplicated hypertension, without a previous myocardial infarction, congestive heart failure, diabetes mellitus or gout, thiazide diuretics appear to be both safe and effective antihypertensive agents.
(19) Ten years ago, we studied the clinical and radiographic manifestations of gout in 60 patients and described 3 patterns of disease.
(20) John Harvey Kellogg, the inventor of Corn Flakes, also invented the sunbed, patenting his first device in 1896 – by royal appointment no less, as Edward VII apparently kept one at Windsor Castle for his gout.