(n.) A powerful vegetable alkaloid, C17H19NO5, extracted from the Colchicum autumnale, or meadow saffron, as a white or yellowish amorphous powder, with a harsh, bitter taste; -- called also colchicia.
Example Sentences:
(1) MAF-G activity was inhibited by mitomycin C and colchicine, which inhibit DNA synthesis and mitosis, respectively, but not by 2-deoxy-D-glucose, an inhibitor of glucose metabolism.
(2) In addition, lightly immunostained cells were distinguished in the caudal portion of the hypothalamic arcuate nucleus, area of tuber cinereum, retrochiasmatic area, and rostral portion of the paraventricular thalamic nucleus after colchicine treatment.
(3) Patients were divided into the following groups: control (followed without specific active treatment), corticosteroid group, azathioprine group, corticosteroid and azathioprine group, chlorambucil group, 5-fluorouracil group, colchicine group and isoprinosine group.
(4) The pHi response induced by the hyperosmotic stress was abolished by two calmodulin inhibitors, W-7 and chlorpromazine (50% inhibition, Ki at 28 and 20 microM, respectively), 20 microM cytochalasin B, but not by 10 microM colchicine.
(5) The increase in human leukocyte adenosine 3':5'-cyclic monophosphate (cyclic AMP) levels seen in response to various substances was markedly potentiated by colchicine and other agents that affect microtubule assembly.
(6) Radioautographic studies of absorptive cells showed that colchicine and nocodazole inhibited labelling of the microvillous border by 67% and 87%, while labelling of the basolateral plasma membrane increased by 114% and 275%.
(7) Pretreatment of the cells with colchicin abolishes the enhancing effect.
(8) The effect of intracerebroventricular injection of the mitosis inhibitor colchicine on expression of mRNA for nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin 3 was studied in the rat brain with in situ hybridization.
(9) Colchicine, which substantially enhanced capping, had no effect on calcium mobilization.
(10) Circulating fibrin was found in patients with FMF in absence of clinical manifestation of thrombosis and was statistically less frequently observed in patients treated with colchicine.
(11) Drugs such as sodium azide, cytochalasin B, colchicine, vinpocetine, and vincristine sulfate reduce binding to the antigen.
(12) No recurrence of synovitis occurred after surgical excision and colchicine therapy but arthralgia persisted.
(13) The resistant strains exhibited cross resistance to anthracycline antibiotics, vinca alkaloids, actinomycin D, colchicine.
(14) Studies of binding and uptake of tritiated colchicine suggested that drug resistance of 3T3r cells might reflect decreased uptake of drug without decreased binding to surface receptors.
(15) We tested nine (cadmium chloride, chloral hydrate, colchicine, diazepam, econazole nitrate, hydroquinone, pyrimethamine, thiabendazole, thimerosal) of the 10 known or suspected spindle poisons of the coordinated programme to study aneuploidy induction sponsored by the Commission of the European Communities using Saccharomyces cerevisiae D61.M (mitotic chromosomal malsegregation system).
(16) There was also local reduction in choline acetyltransferase (ChAT) activity and significant losses of 55-kDa protein in the soluble fraction and of 50-kDa protein in myelin and synaptosomal fractions in the hippocampi of colchicine-lesioned rats.
(17) Treatment of the acute phase in which ample use is made of colchicine must be followed by medical and dietary treatment of the chronic condition.
(18) However, preliminary results from a randomized placebo-controlled clinical trial suggest that low dose colchicine (0.6 mg twice a day orally) does not prevent restenosis.
(19) The recent discovery that an age-old drug, colchicine, can control this enigmatic, often unrecognized, recurrent disease means that most affected individuals can now lead virtually normal lives.
(20) After an intraventricular colchicine administration, NPY was found in many AVP-deficient non-oxytocinergic magnocellular neurons of the paraventricular and supraoptic nuclei in BB rats, but not in suprachiasmatic nucleus neurons.
Rheumatic
Definition:
(a.) Derived from, or having the character of, rheum; rheumic.
(a.) Of or pertaining to rheumatism; as, rheumatic pains or affections; affected with rheumatism; as, a rheumatic old man; causing rheumatism; as, a rheumatic day.
(n.) One affected with rheumatism.
Example Sentences:
(1) 278 children with bronchial asthma were medically, socially and psychologically compared to 27 rheumatic and 19 diabetic children.
(2) Although the incidence of acute rheumatic fever has declined in the last decades, a few outbreaks have recently been reported.
(3) No cases of rheumatic fever and no acute nephritis appeared in spite of the vigorous immune response to both cellular and extracellular antigens of group A streptococci documented in 50% to 80% of patients, suggesting that strain variation may be a feature of rheumatogenicity as well as nephritogenicity of group A streptococcal pharyngitis.
(4) A case of post streptococcal acute glomerulonephritis co-existing with acute rheumatic fever is reported.
(5) Capillary neogenesis, probably in reaction to subclinical cutaneous vascularity, was detected in 59% of cases (86% of subjects presenting extra-articular rheumatism).
(6) In 53 patients with rheumatic mitral stenosis we performed echocardiographic study in order to define anatomic and functional alterations.
(7) Seventeen patients were diagnosed as having primary rheumatic carditis, 9 presented with tonsillogenic rheumatic carditis, and 16 had viral rheumatic carditis.
(8) However, antibodies to native DNA and to nuclear ribonucleoprotein were found in a variety of systemic rheumatic diseases.
(9) The Council on Rehabilitative Rheumatology of the American Rheumatism Association, through the Education Subcommittee, surveyed directors of 69 approved rehabilitation medicine residency training programs to assess the nature of training in rehabilitative-rheumatology and whether the directors believed this training to be adequate.
(10) Arthrography before isotope synoviorthesis of the fingers and wrists was carried out in 185 patients suffering from inflammatory rheumatic conditions.
(11) This study has identified a new marker, antibodies against a nuclear RNP protein of 56 KD for detecting muscle involvement among the autoimmune rheumatic diseases.
(12) Mitral valve leaflets were smooth and white in a patients without mitral valvular disease, while the leaflets were yellow, thick and irregular, and blood regurgitation from the left ventricle into the left atrium could be observed in two patients with rheumatic MSR.
(13) Immunological functions were investigated in 10 children with acute rheumatic fever and 11 children with acute nephritis to try and elucidate the cause of heart damage in acute rheumatic fever.
(14) In patients suffering of latent rheumatism with a subminimal activity, no increased number of circulating eosinophils is observed.
(15) 107 Consecutive patients with rheumatic valvular heart disease (41 males, 66 females, average age 24.2 years) being followed at an Ethiopian cardiology referral clinic were examined and questioned about their experience of hemoptysis.
(16) In summary, our findings support the view that implication of CD8(+)-T-cell activation is different in the pathogenesis of each rheumatic disease.
(17) The weakening of rosette-forming function of lymphocytes, a decrease in a mitogenic response to PHA, dysimmunoglobulinemia, imbalance in antibody production, particularly hyperproduction of cardial antibodies in rheumatic fever were observed as was marked delayed-type hypersensitivity to tissue antigens, more frequently to purified cardial antigens--to myocardial cell membranes and myosin.
(18) In conclusion, rheumatic disease is still a frequent cause for surgical replacement of the aortic valve.
(19) The authors present four cases of rheumatic heart disease with severe dilatation of the left atrium which reached the right profile in the radiologic study.
(20) The accent in rheumatism orthopedics should gradually shift toward early preventive operation.