(n.) Deprived of heat, or having a low temperature; not warm or hot; gelid; frigid.
(n.) Lacking the sensation of warmth; suffering from the absence of heat; chilly; shivering; as, to be cold.
(n.) Not pungent or acrid.
(n.) Wanting in ardor, intensity, warmth, zeal, or passion; spiritless; unconcerned; reserved.
(n.) Unwelcome; disagreeable; unsatisfactory.
(n.) Wanting in power to excite; dull; uninteresting.
(n.) Affecting the sense of smell (as of hunting dogs) but feebly; having lost its odor; as, a cold scent.
(n.) Not sensitive; not acute.
(n.) Distant; -- said, in the game of hunting for some object, of a seeker remote from the thing concealed.
(n.) Having a bluish effect. Cf. Warm, 8.
(n.) The relative absence of heat or warmth.
(n.) The sensation produced by the escape of heat; chilliness or chillness.
(n.) A morbid state of the animal system produced by exposure to cold or dampness; a catarrh.
(v. i.) To become cold.
Example Sentences:
(1) The judge, Mr Justice John Royce, told George she was "cold" and "calculating", as further disturbing details of her relationship with the co-accused, Colin Blanchard and Angela Allen, emerged.
(2) Video games specialist Game was teetering on the brink of collapse on Friday after a rescue deal put forward by private equity firm OpCapita appeared to have been given the cold shoulder by lenders who are owed more than £100m.
(3) "There is a serious risk that a deal will be agreed between rich countries and tax havens that would leave poor countries out in the cold.
(4) Results demonstrate that the development of biliary strictures is strongly associated with the duration of cold ischemic storage of allografts in both Euro-Collins solution and University of Wisconsin solution.
(5) These data suggest that submaximal exercise and cold air exposure enhance nonspecific bronchial reactivity in asthmatic but not in normal subjects.
(6) The relationship between cold-insoluble complexes, or cryoglobulins, and renal disease was studied in rabbits with acute serum sickness produced with BSA.
(7) Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 1983, pp.
(8) Changes in pain tolerance after administration of differently labelled placebos were studied by measuring the reaction time after a cold stimulus.
(9) The quality of liver grafts was evaluated using an original, blood-free isolated perfusion model, after 8 h cold storage, or after 15 min warm ischemia performed prior to harvesting.
(10) Lymphocytes of inbred mice immunized with allogenic tumour cells were labelled in vitro or in vivo by 3H-thymidine, washed out and incubated with target cells in the presence of "cold" thymidine.
(11) The binding of 125I-labeled core protein to immobilized fibronectin was inhibited by soluble fibronectin and by soluble cold core protein but not by albumin or gelatin.
(12) "The government should be doing all it can to put the UK at the forefront of this energy revolution not blowing hot and cold on the issue.
(13) 1, diarrhea lowered the piglet's ability to maintain body temperature during the cold test.
(14) 3H-uridine or 3H-uracil with cold uridine and uracil, respectively, in amounts corresponding to therapeutic doses of these two pyrimidines as fluoro compounds, were administered with or without microspheres.
(15) To a large extent, the failure has been a consequence of a cold war-style deadlock – Russia and Iran on one side, and the west and most of the Arab world on the other – over the fate of Bashar al-Assad , a negotiating gap kept open by force in the shape of massive Russian and Iranian military support to keep the Syrian regime in place.
(16) For a union that, in less than 25 years, has had to cope with the end of the cold war, the expansion from 12 to 28 members, the struggle to create a single currency and, most recently, the eurozone crisis, such a claim risks accusations of hyperbole.
(17) A comparison is made between these results and those of other authors who observed microtubule disaggregation by cold with the electron microscope.
(18) Raised cold agglutinin titres were observed in 16 patients with atypical pneumonia.
(19) This initial observation of release of eosinophil chemotactic factor of anaphylaxis in vivo along with histamine assigns the mast cell a central role in cold urticaria.
(20) Detection limits were then calculated for the different sizes of cold spots.
Dextromethorphan
Definition:
Example Sentences:
(1) Thus the innocuousness and ubiquitous availability of dextromethorphan render it attractive for worldwide pharmacogenetic investigations in man.
(2) The effects of both opioid (morphine and dihydrocodeine) and nonopioid (dextromethorphan and noscapine) antitussive drugs were diminished in morphine-dependent rats.
(3) In addition, the previous blockade by ketamine and dextromethorphan of NMDA receptors has been shown to intensify the naloxone-elicited morphine abstinence syndrome.
(4) Protection by codeine 20 mg, dextromethorphan 30 mg, noscapine 30 mg, and placebo against citric acid-induced cough was determined in eighteen healthy subjects.
(5) The K+ outflow via nicotinic ACh receptor cation channels was inhibited by various psychotomimetic sigma ligands in the sequence of PCP, dextromethorphan >> DTG, MK 801, (+)SKF10047 >> (+)3-PPP.
(6) In a preliminary study, different rates of N-, O- and N,O- demethylation of dextromethorphan to yield D-methoxymorphinane, dextrorphan and D-hydroxymorphinane, respectively, were found in extensive- (Sprague-Dawley) and poor-metabolizer (female dark Agouti) rat strains.
(7) Codeine and dextromethorphan were N-demethylated in human foetal liver microsomes at high rates which were close to the activities in adult livers.
(8) The purpose of this study was to determine whether dextromethorphan, an opioid class antitussive, prevents hypoxia-induced loss of nerve function in an in vitro hippocampal slice preparation.
(9) The concentrations of dextrorphan were 170 times higher than the concentrations of dextromethorphan.
(10) Anticonvulsant and neuroprotective properties have been demonstrated, and treatment with dextromethorphan has been shown to improve the cerebrovascular and functional consequences of global cerebral ischemia.
(11) Both bufuralol and dextromethorphan are well-known substrates of cytochrome P450IID6.
(12) Male and female rats exhibited striking differences in their ability to metabolize dextromethorphan.
(13) Moreover, genotypic identification of heterozygous and homozygous extensive metabolizer subjects did not predict CYP2D6 activity, as determined by dextromethorphan and encainide metabolic ratios, or encainide response, as determined by intraventricular and atrioventricular changes.
(14) The N-methyl-D-aspartate (NMDA) antagonists dextromethorphan (DM) and dextrorphan (DX) were found to reduce significantly neocortical severe ischemic neuronal damage (SIND) when administered in a delayed fashion after the ischemic insult.
(15) The anticonvulsant potency of these compounds, (+)-5-methyl-10,11- dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK-801) greater than dextrorphan greater than or equal to 1-(1-phenylcyclohexyl)piperidine hydrochloride (PCP) greater than dextromethorphan greater than (+)-pentazocine, upon microinjection into the prepiriform cortex, was highly correlated (r = 0.971; P less than 0.01) with their respective affinities for the [3H]dextrorphan-labelled NMDA receptors in rat forebrain membranes.
(16) In the dextromethorphan-treated animals, 90% of the rats survived compared with 47% of the untreated animals (p less than 0.05).
(17) A centrally acting antitussive agent dextromethorphan (DM) was tested to determine its possible interaction with naloxone in rats responding under a fixed-interval schedule of positive reinforcement.
(18) Simple, sensitive and selective enzyme immunoassays (ELISA) for monitoring urinary dextromethorphan and its major metabolite, dextrorphan, were developed.
(19) The results indicate that salbutamol has antitussive action enhancing the effect of plain dextromethorphan.
(20) In the present investigation, the effects of sigma ligands [WY-47384 [8-fluoro-2,3,4,5-tetrahydro-2[3-(3-pyridinyl)propyl)1H- pyrido(4,3b)indole], (+)-pentazocine, (+)-SFK 10,047 (N-allylnormetazocine), mafoprazine, opipramol, dextromethorphan, dextrorphan, (+)-3-PPP [3-(3-hydroxyphenyl)-N-propylpiperidine], (-)-butaclamol, DTG [1,3-di(2-tolyl)guanidine], rimcazole, ifenprodil and BMY-14802 [alpha-(fluorophenyl)-4-(5-fluoropyrimidinyl)-1-piperazine butanol]] on harmaline-, pentylenetetrazol (PTZ)-, methamphetamine (MA)- and D-serine-induced increases in mouse cerebellar levels of cGMP were determined.