(n.) In the East Indies, an inclosure containing a house, outbuildings, etc.
(v. t.) To form or make by combining different elements, ingredients, or parts; as, to compound a medicine.
(v. t.) To put together, as elements, ingredients, or parts, in order to form a whole; to combine, mix, or unite.
(v. t.) To modify or change by combination with some other thing or part; to mingle with something else.
(v. t.) To compose; to constitute.
(v. t.) To settle amicably; to adjust by agreement; to compromise; to discharge from obligation upon terms different from those which were stipulated; as, to compound a debt.
(v. i.) To effect a composition; to come to terms of agreement; to agree; to settle by a compromise; -- usually followed by with before the person participating, and for before the thing compounded or the consideration.
(v. t.) Composed of two or more elements, ingredients, parts; produced by the union of several ingredients, parts, or things; composite; as, a compound word.
(n.) That which is compounded or formed by the union or mixture of elements ingredients, or parts; a combination of simples; a compound word; the result of composition.
(n.) A union of two or more ingredients in definite proportions by weight, so combined as to form a distinct substance; as, water is a compound of oxygen and hydrogen.
Example Sentences:
(1) These factors might account for the lower systemic bioavailability of these compounds.
(2) The interaction of the antibody with both the bacterial and the tissue derived polysialic acids suggests that the conformational epitope critical for the interaction is formed by both classes of compounds.
(3) These organic compounds were found to be stable on the sorbent tubes for at least seven days.
(4) Compound Z has the properties expected of an oxidized MPT precursor.
(5) Although Jeggo's Chinese hamster ovary cells were more responsive to mAMSA, novo still abrogated mAMSA toxicity in the mutant cells as well as in the parental Chinese hamster ovary cells 2,4-Dinitrophenol acted similarly to novo with respect to mAMSA killing, but neither compound reduced the ATP content of V79 cells.
(6) Recent data collected by the Games Outcomes Project and shared on the website Gamasutra backs up the view that crunch compounds these problems rather than solving them.
(7) There fore, the adverse effects may be induced by such quartz or silicon compounds.
(8) Fluorination with [18F]acetylhypofluorite yields 6-[18F]fluoro-L-dopa with 95% radiochemical purity; fluorination of the same substrate with [18F]F2 yields a mixture of all three structural isomers in a ratio of 70:16:14 for 6-, 5-, and 2-fluoro compounds.
(9) Mitonafide is the lead compound of a new series of antitumor drugs, the 3-Nitronaphthalimides, which have shown antineoplastic activity in vitro as well as in vivo.
(10) We have examined the activities of X, Y, and several related compounds as activators of macrophages.
(11) [125I]ET-1 binding to ETB receptors (nonselective to ET isopeptides) in cerebellar membranes was not inhibited by either of these compounds even at 100 microM.
(12) The individual classes of drugs are first treated separately to highlight specific aspects of their quantification, and this is followed by an overview of those methods permitting the concomitant analysis of two or more antiepileptic compounds.
(13) The remainder of the radioactivity appeared chromatographically just prior to the bisantrene peak, indicating that compounds more polar than the parent were present as transformation products.
(14) The ADAM derivative of carnitine was separated from decomposition products of the reagent and related compounds such as amino acid derivatives on a silica gel column eluted with methanol-5% aqueous SDS-phosphoric acid (990:10:1).
(15) Accidentally discovered nearly 40 years ago as the first true antidepressants, the MAOIs soon fell into disfavor due to concerns about toxicity and seemingly lesser efficacy compared with the newer tricyclic compounds.
(16) In a series of compounds with H2-antihistaminic activity, a conformational analysis was performed based on force field calculations.
(17) All three compounds were also very similar in their effects on [3H]5HT release from superfused rat striatal slices.
(18) A new compound, 5-bromo-2-(N,N-dimethylaminomethyl)furnan (IIc), is prepared in a similar way.
(19) On the basis of obtained data on the uniformity of chemical compounds of the secretion of glands belonging to different groups their common origin has been suggested.
(20) S-methyl-l-cysteine, 2-hydroxy-4-methiol butyric acid, S-adenosyl-l-methionine, and methionine peptides were the only compounds supporting growth, when substituted for methionine.
Thiophene
Definition:
(n.) A sulphur hydrocarbon, C4H4S, analogous to furfuran and benzene, and acting as the base of a large number of substances which closely resemble the corresponding aromatic derivatives.
Example Sentences:
(1) Quantitative structure activity relationships of 2-amino-3-carboxylic acid ethyl ester thiophene derivatives are described.
(2) Some of the thiophenes and their acetylenic derivatives possess extremely potent phototoxic activities toward membrane-containing viruses.
(3) The compounds were obtained by condensation of appropriate hydrazines with thiophene 2-carboxaldehyde (series 1), thiophene 3-carboxaldehyde (series 2), and 5-nitrothiophene-2-carboxaldehyde (series 3).
(4) The prototype kappa-selective agonist, PD117302 (trans-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzo[b]thiophene-4- acetamide, 2) has been regio- and stereoselectively substituted in the C-4 and C-5 positions of the cyclohexyl ring with the methyl ether and spiro tetrahydrofuran groups.
(5) Since no previously identified genes involved in thiophene metabolism are located in this region, we designated the gene for the 48-kDa protein as thdF.
(6) Among the compounds described are 6-hydroxybenzo[b]thiophene-2-sulfonamide (16) and its acetate ester (23), which are among the most potent ocular hypotensive agents in this class, as assessed in the alpha-chymotrypsinized rabbit.
(7) The normalizing effects of the thiophene compounds on serum phosphorus levels were not significant at the dosages used.
(8) Maximum photo-basophil-histamine-release was 4% with acetylsalicylic acid, 10% with benoxaprofen, 20% with thiophene, 28% with diclofenac, 39% with tiaprofenic acid, 40% with carprofen, 55% with ketoprofen, and not demonstrable with indoprofen.
(9) The more hydrophobic cephalosporins, with a thiophene moiety at the C7 position, were more active than C7-methoxyiminoaminothiazole derivatives against S. aureus H (beta-lactam-susceptible), and compounds with a thioether function at C3 were more active than those with a sulphonyl function at this position.
(10) Several guanidine compounds were synthesized by the reaction of acid chlorides of thiophene and furan with guanidines.
(11) Alpha-terthienyl (alpha-T), a phototoxic thiophene compound isolated from marigolds (Tagetes species), affects cell membranes and does not appear to induce cytogenetic damage.
(12) In a directed search for the best compounds for clinical evaluation, some 150 selected nitroaromatic compounds, representing 6 distinct types, namely, furans, thiophenes, imidazoles, pyrazoles, pyrroles, and triazoles, have been synthesized and tested as hypoxic cell radiosensitisers and bioreductive drugs.
(13) Replacement of ring A by heterocyclic rings (thiophene or pyridine) leads to analogues with only moderate activity.
(14) These results clearly show that all three thiophene systems have potent activity as antihypertensive agents and that 3 and 4 are more potent than 1 or 2 as alpha 1-antagonists in vivo.
(15) A comparative study of the intestinal transport of DL-tryptophan and its 1-methylindole (tryptophan-l-Me) and benzo[b]thiophene (tryptophan-S) analogs has been carried out in vitro, using the everted intestinal sac of the rat and hamster.
(16) Except for cardioselectivity at low doses, the thiophenic analogue of metoprolol behaves in a very similar way as this compound in all the aspects considered in a preliminary pharmacological study.
(17) Six-month chronic oral toxicity studies of 7-chloro-3-[1-(2, 4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethoxy-methyl] benzo[b]thiophene (sertaconazole, FI-7045, CAS 99592-32-2) were carried out in rats and ferrets.
(18) N-(3-dimethylaminopropyl)naphtho[2,1-b]thiophene-4-carboxamide and the 6-substituted methoxy, methyl, fluoro, chloro, bromo, trifluoromethyl, and cyano derivatives have been shown to bind to DNA via intercalation with binding constants in the 35-900 X 10(3) range at 25 degrees C, pH 7, and [Na+] = 0.019M.
(19) Tienilic acid (TA) is metabolized by human liver microsomes in the presence of NADPH with the major formation of 5-hydroxytienilic acid (5-OHTA) which is derived from the hydroxylation of the thiophene ring of TA.
(20) The synthesis of 1-substituted benzothieno[2,3-d]imidazoles and their most suitable synthesis precursor 2-nitro-3-substituted-amino benzo[b]thiophenes is reported.