(1) The interaction of the antibody with both the bacterial and the tissue derived polysialic acids suggests that the conformational epitope critical for the interaction is formed by both classes of compounds.
(2) It has been conformed that catalase from bovine liver eliminates only the pro R hydrogen atom from ethanol.
(3) The high transition enthalpy for kerasin is ascribed to a lesser accommodation of gauche conformers in the hydrocarbon chains just below the transition temperature.
(4) The Tyr side chain had two conformations of comparable energy, one over the ring between the Gln and Asn side chains, and the other with the Tyr side chain away from the ring.
(5) In a series of compounds with H2-antihistaminic activity, a conformational analysis was performed based on force field calculations.
(6) Recently, we have designed a series of simplified artificial signal sequences and have shown that a proline residue in the signal sequence plays an important role in the secretion of human lysozyme in yeast, presumably by altering the conformation of the signal sequence [Yamamoto, Y., Taniyama, Y., & Kikuchi, M. (1989) Biochemistry 28, 2728-2732].
(7) The molecule may already in its native form have an extended conformation containing either free sulfhydryl groups or small S-S loops not affecting mobility in SDS-PAGE.
(8) In 0.17 M Na+(aq), tRNA(Phe) exists in its native conformation and the number of strong binding sites (Ka greater than or equal to 10(4)) was estimated to be 3-4 by titration experiments, in agreement with X-ray structural data for crystalline tRNA(Phe) (Jack et al., 1977).
(9) In voltage-clamp experiments the ion current flowing through the channels was homogeneous indicating a defined conformation and a uniform size.
(10) However, it does not and we therefore propose the presence of an unusual DNA conformation in these regions.
(11) We propose that, for a GC base pair in B conformation, there are two amino proton exchangeable states--a cytosine amino proton exchangeable state and a guanine amino proton exchangeable state; both require the disruption of only the corresponding interbase H bond.
(12) In air-saturated solutions of DNA, yields of 8-hydroxypurines were not influenced greatly by DNA conformation.
(13) A detailed stereochemical analysis of known protein structures has been made which shows that: (1) irregular regions of proteins consist of a limited number of standard structures formed by three, four of more residues; (2) an amino acid residue of a protein can adopt one of the six sterically allowed conformations designated here as alpha, alpha L, beta, gamma, delta, and epsilon.
(14) The substructural units, 5-14 linear and 5-14 cyclic, have been used as models for MCH-- H-Asp1-Thr-Met-Arg-Cys-Met-Val-Gly-Arg HO-Val17-Glu-Trp-Cys-Pro-Arg-Tyr-Val in 1H-nmr conformational studies.
(15) The conformations of each peptide in various solvents were determined by CD and ir spectroscopy in order to relate immunological to structural properties.
(16) All data did, however, conform to normal distribution expectations.
(17) The conformations of cysteamine, thiazolidine, and thiazolidine-4-carboxylic acid were determined in aqueous solutions using NMR spectroscopy.
(18) This structural change opens the heme pocket and modifies the general conformation of the EF segment, thus explaining the increase in oxygen affinity and the achievement of a three-dimensional structure favoring asparagine deamidation.
(19) It is likely that the molecule undergoes a conformational change when it is bound to the receptor.
(20) The phenylalanine-dependent conformation and the leucine-dependent conformation differ considerably.
Unacceptable
Definition:
(a.) Not acceptable; not pleasing; not welcome; unpleasant; disagreeable; displeasing; offensive.
Example Sentences:
(1) The obvious need for highly effective contraception in women with existing disorders of glucose metabolism has led to a search for oral contraceptive (OC) regimens for such women that are efficient but without unacceptable metabolic side effects.
(2) The European commission president, José Manuel Barroso, and the EU council president, Herman Van Rompuy, were both right to brand it unacceptable.
(3) Unacceptable toxicity occurred in 27% of patients initially treated at the high dose and only in 10% of those who had progressive dose escalation up to 36 X 10(6) units.
(4) Doreen Lawrence to speak at conference on police spying, corruption and racism Read more Mick Creedon, the Derbyshire Chief Constable who is leading the police’s internal investigation into the SDS, said the public inquiry “will help us with the work that is already underway to make sure that the unacceptable behaviour of some officers in the past never happens again”.
(5) Trade unions criticised the corporation’s 1% offer, tied to a minimum of just £390, for those staff earning under £50,000, calling it “completely unacceptable” .
(6) Miliband said: "Unfair pricing which hits the most vulnerable hardest is completely unacceptable.
(7) The councillors, including Philip Glanville, Hackney’s cabinet member for housing, said they had previously urged Benyon and Westbrook not to increase rents on the estate to market values, which in some cases would lead to a rise from about £600 a month to nearer £2,400, calling such a move unacceptable.
(8) His companions eventually apologised to me, but only after apologising to my boyfriend, and only after being kicked out by restaurant staff who reinforced that the behaviour was unacceptable.
(9) This is just one of the many blameworthy behaviors that young spring breakers have shown recently in Cancún and that are described as acts of xenophobia and discrimination against Mexicans within their own country, which is (or should be) totally unacceptable.” The story took off.
(10) There were large individual differences among rats selecting from pairs of unacceptable diets.
(11) I would have feared that doing as Proudman did and calling out behaviour that I found unacceptable would have been the end of my career, I would have let it go.
(12) Marginal overhang was the prevailing type of failure (17%), recurrent caries occurred at 12% of the restorations, unacceptable proximal contact at 10%, unacceptable marginal adaptation at 8% and isthmus fractures at 2%.
(13) This was unacceptable to everyone since it gave the UK a veto over reinstating the arms ban.
(14) In an effort to relieve subvesical resistance in the established paraplegic with unacceptable neurogenic vesical dysfunction while simultaneously preserving potency, a radical Y-V-plasty was carried out in 5 patients.
(15) Of these, practolol, phentolamine, practolol-phentolamine, phentolamine-practolol, promethazine, hexamethonium, procainamide and verapamil were unacceptable.
(16) Firstly, missing anterior teeth result in unacceptable changes in appearance and speech, making treatment mandatory.
(17) It is noted that we are still very dependent on A-V shunts for vascular access in end stage renal disease (ESRF) patients and this is associated with an unacceptable level of complications.
(18) In this patient, azathioprine induced and sustained a remission when unacceptably high doses of prednisone had failed, and may prove to be a valuable immunosuppressive in non-responsive coeliac disease.
(19) UK prison population is biggest in western Europe Read more The final version of the inspection report remains highly critical of conditions in Wormwood Scrubs, where outcomes for the 1,258 men held there are still “unacceptably poor”.
(20) Storage in plastic for even 30 days resulted in unacceptable loss of potency (greater than 15%) and formation of a brown precipitate.