(n.) To draw together or nearer; to reduce to a less compass; to shorten, narrow, or lessen; as, to contract one's sphere of action.
(n.) To draw together so as to wrinkle; to knit.
(n.) To bring on; to incur; to acquire; as, to contract a habit; to contract a debt; to contract a disease.
(n.) To enter into, with mutual obligations; to make a bargain or covenant for.
(n.) To betroth; to affiance.
(n.) To shorten by omitting a letter or letters or by reducing two or more vowels or syllables to one.
(v. i.) To be drawn together so as to be diminished in size or extent; to shrink; to be reduced in compass or in duration; as, iron contracts in cooling; a rope contracts when wet.
(v. i.) To make an agreement; to covenant; to agree; to bargain; as, to contract for carrying the mail.
(a.) Contracted; as, a contract verb.
(a.) Contracted; affianced; betrothed.
(n.) The agreement of two or more persons, upon a sufficient consideration or cause, to do, or to abstain from doing, some act; an agreement in which a party undertakes to do, or not to do, a particular thing; a formal bargain; a compact; an interchange of legal rights.
(n.) A formal writing which contains the agreement of parties, with the terms and conditions, and which serves as a proof of the obligation.
(n.) The act of formally betrothing a man and woman.
Example Sentences:
(1) During the performance of propulsive waves of the oesophagus the implanted vagus nerve caused clonic to tetanic contractions of the sternohyoid muscle, thus proving the oesophagomotor genesis of the reinnervating nerve fibres.
(2) But RWE admitted it had often only been able to retain customers with expired contracts by offering them new deals with more favourable conditions.
(3) Thus adrenaline, via pre- and post-junctional adrenoceptors, may contribute to enhanced vascular smooth muscle contraction, which most likely is sensitized by the elevated intracellular calcium concentration.
(4) Further, the maximal increase in force of contraction was measured using papillary muscle strips from some of these patients.
(5) When subjects centered themselves actively, or additionally, contracted trunk flexor or extensor muscles to predetermined levels of activity, no increase in trunk positioning accuracy was found.
(6) Twitch-tetanus ratios were calculated and found not to be related to unit contraction time.6.
(7) Selective removal of endothelium had no effect on BK-induced contraction or the action of the antagonists.
(8) The increased muscular strength in due to a rise of calcaemia, improved muscle contraction and probably also due to the mentioned nutritional factors.
(9) However, there was not a relationship between the contraction curve of the gallbladder and the bile flow into the duodenum.
(10) In in vitro preparations GABA (10(-7) - 10(-3) M) elicited a dose-dependent relaxation; a decrease in the spontaneous contractions was sometimes observed.
(11) There was no correlation between disturbed gastric clearance, impaired gall bladder contraction, and prolonged colonic transit time in the patients with cardiovascular autonomic neuropathy nor was there a correlation between any disturbed motor function and age or duration of diabetes.
(12) Noradrenaline decreased the phasic contraction amplitude of the circular muscle and exerted a stimulant effect on the tone which suggested an existence of two alpha 1-adrenoceptor subtypes.
(13) It may, however, be useful to compare local wall dynamics in the more isometrically-contracting basal segment with those in the middle portion which brings about most of the emptying of the ventricle.
(14) Upon depletion of ATP in contraction, the P2 intensity reverted to the original rigor level, accompanied by development of rigor tension.
(15) L-NAME abolished B contractions in a dose-dependent fashion.
(16) The power spectrum of the EMG was analyzed during isometric contractions of the shoulder muscles.
(17) A23187 had only a transient effect on KCl-contracted coronary arteries.
(18) When caffeine evokes a contraction, and only then, crayfish muscle fibers become refractory to a second challenge with caffeine for up to 20 min in the standard saline (5 mM K(o)).
(19) Dopamine at concentrations over 10(-5)M induced contractions of tracheal muscle strips and repeated exposures resulted in desensitization (tachyphylaxis) of the muscle.
(20) In the present study we examined cholecystokinin release and gallbladder contraction after oral administration of a commercial fatty meal (Sorbitract; Dagra, Diemen, The Netherlands) using ultrasonography in eight normal subjects and eight gallstone patients before and after 1 and 4 weeks of treatment with ursodeoxycholic acid (10 mg kg-1.day-1).
Unbind
Definition:
(v. t.) To remove a band from; to set free from shackles or fastenings; to unite; to unfasten; to loose; as, unbind your fillets; to unbind a prisoner's arms; to unbind a load.
Example Sentences:
(1) Thus, although the fast sodium inactivation process is not required for tonic and use-dependent block of INa by disopyramide, it contributes to the fast phase of block development and unbinding from use-dependent block.
(2) Two calcium antagonistic drugs, nifedipine and mesudipine, were investigated and as a result averaged rate constants of binding and unbinding were evaluated.
(3) Physical theories have been developed to describe many aspects of their conformational behaviour, such as the preferred shapes and shape transformations of closed vesicles, and the shape fluctuations, random-surface configurations, and adhesion and unbinding of interacting membranes.
(4) Assuming a reversible one-to-one binding reaction, the time course of DHO binding and unbinding was analysed under a variety of conditions.
(5) Sanguinarine may produce a K+-like effect upon the Na pump with consequent unbinding of ouabain.
(6) The rate constants for binding and unbinding of ATP were estimated from the dependence of the mean open time on [ATP] and from the Ki.
(7) The rate for unbinding during depolarization was independent of pHo.
(8) We suggest that these conformational changes arise from the unbinding to DNA of certain basic tails of histone(s), and that a competition for DNA binding locations exists upon the reassociation.
(9) These findings suggest than AN-132 has use dependent inhibitory action on the fast sodium channel by binding to the channel mainly during its activated state and that the unbinding rate of the drug during diastole is very slow.
(10) Because in most cases these fit a single exponential with a mean open duration like that of modified channels, we conclude that voltage-dependent toxin unbinding produced a mixed population of unmodified and modified openings.
(11) The extent of the contribution of the process of agonist binding and unbinding to adenylate cyclase activation has not been demonstrated or quantified.
(12) It is interesting that encainide and flecainide unbind slowly (15-20 seconds), whereas lidocaine and moricizine unbind rapidly (0.2-1.3 seconds).
(13) Therefore, sodium channel states regulate the binding and unbinding behaviour of antiarrhythmic drugs.
(14) Such [Ca2+]i-transients in muscle are actually subcellular spatio-temporal events that are determined dynamically by i) diffusional fluxes of Ca2+, ii) by the binding or unbinding of Ca2+ to ligands such as troponin c and calmodulin, and iii) by the various cellular processes, such as release of Ca2+ from sarcoplasmic reticulum, that produce fluxes of Ca2+ across the membranes bounding organelles or the cell.
(15) According to the model, RAC109-I and RAC109-II have significantly different unbinding rate constants for channels when they exist predominantly in rested, activated, or inactivated states, as well as significantly different binding rate constants when channels are activated.
(16) We conclude that binding and unbinding of one molecule of ATP determine the gating of ATP-sensitive K+ channel.
(17) The dissociation rate constant of DHO unbinding remained unchanged (approximately 0.06 s-1).
(18) Estimates of binding and unbinding rate constants for the sodium channel during the action potential plateau and after repolarization were of the same order as previous results obtained using microelectrode methods in vitro.
(19) Increasing the concentration of drug increased the rate of binding but had little or no effect on unbinding, as expected for a simple bimolecular reaction.
(20) Binding and unbinding of MK-801 seems to be possible only if the N-Me-D-Asp-operated channel is in the transmitter-activated state: MK-801 was effective only when applied simultaneously with N-Me-D-Asp, and recovery from MK-801 blockade was speeded by continuous exposure to N-Me-D-Asp [time constant (tau) approximately equal to 90 min at -70 to -80 mV].