(n.) The act of moving from one point to another; progress; passage.
(n.) The ground or path traversed; track; way.
(n.) Motion, considered as to its general or resultant direction or to its goal; line progress or advance.
(n.) Progress from point to point without change of direction; any part of a progress from one place to another, which is in a straight line, or on one direction; as, a ship in a long voyage makes many courses; a course measured by a surveyor between two stations; also, a progress without interruption or rest; a heat; as, one course of a race.
(n.) Motion considered with reference to manner; or derly progress; procedure in a certain line of thought or action; as, the course of an argument.
(n.) Customary or established sequence of events; recurrence of events according to natural laws.
(n.) Method of procedure; manner or way of conducting; conduct; behavior.
(n.) A series of motions or acts arranged in order; a succession of acts or practices connectedly followed; as, a course of medicine; a course of lectures on chemistry.
(n.) The succession of one to another in office or duty; order; turn.
(n.) That part of a meal served at one time, with its accompaniments.
(n.) A continuous level range of brick or stones of the same height throughout the face or faces of a building.
(n.) The lowest sail on any mast of a square-rigged vessel; as, the fore course, main course, etc.
(n.) The menses.
(v. t.) To run, hunt, or chase after; to follow hard upon; to pursue.
(v. t.) To cause to chase after or pursue game; as, to course greyhounds after deer.
(v. t.) To run through or over.
(v. i.) To run as in a race, or in hunting; to pursue the sport of coursing; as, the sportsmen coursed over the flats of Lancashire.
(v. i.) To move with speed; to race; as, the blood courses through the veins.
Example Sentences:
(1) This particular variant of rheumatoid arthritis (RA) is characterized by the presence of subcutaneous rheumatoid nodules, scanty or absent systemic manifestations and a clinically benign course.
(2) A 2.5-month-old child with cyanotic heart disease who required long-term PGE1 infusions; developed widespread periosteal reactions during the course of therapy.
(3) These included bringing in the A* grade, reducing the number of modules from six to four, and a greater attempt to assess the whole course at the end.
(4) Therefore, it is suggested that PE patients without endogenous erythroid colonies may follow almost the same clinical course as SP patients.
(5) Twenty-seven patients were randomized to receive either 50 mg stanozolol or placebo intramuscularly 24 h before operation, followed by a 6 week course of either 5 mg stanozolol or placebo orally, twice daily.
(6) It is followed by rapid neurobehavioral deterioration in late infancy or early childhood, a developmental arrest, plateauing, and then either a course of retarded development or continued deterioration.
(7) In dorsoventral (DV) reversed wings at both shoulder or flank level, the motor axons do not alter their course as they enter the graft.
(8) The program met with continued support and enthusiasm from nurse administrators, nursing unit managers, clinical educators, ward staff and course participants.
(9) Of course the job is not done and we will continue to remain vigilant to all risks, particularly when the global economic situation is so uncertain,” the chancellor said in a statement.
(10) low molecular weight dextran in the course of right heart catheterization.
(11) Community involvement is a key element of the Primary Health Care (PHC) approach, and thus an essential topic on a course for managers of Primary Health Care programmes.
(12) The time-course and dose-response for this modification of pp60c-src paralleled PDGF-induced increases in phosphorylation of pp36, a major cellular substrate for several tyrosine-specific protein kinases.
(13) The evidence suggests that by the age of 15 years many adolescents show a reliable level of competence in metacognitive understanding of decision-making, creative problem-solving, correctness of choice, and commitment to a course of action.
(14) The course of urogenital tuberculosis is complicated by unspecific bacterial infections of the urinary tract and nephrolithiasis.
(15) In the course of the syndrome development blood vessel permeability was increased in the anterior chamber of the eye.
(16) Mieko Nagaoka took just under an hour and 16 minutes to finish the race as the sole competitor in the 100 to 104-year-old category at a short course pool in Ehime, western Japan , on Saturday.
(17) The time course of the current potentiation was similar to that seen with beta-adrenergic stimulation.
(18) Such complications as intracerebral haematoma or meningeal haemorrhage may occur during the usually benign course of the disease.
(19) Several dimensions of the outcome of 86 schizophrenic patients were recorded 1 year after discharge from inpatient index-treatment to complete a prospective study concerning the course of illness (rehospitalization, symptoms, employment and social contacts).
(20) The course was further complicated by administration of gentamicin, an antibiotic known to potentiate neuromuscular blocking drugs.
Rough
Definition:
(n.) Having inequalities, small ridges, or points, on the surface; not smooth or plain; as, a rough board; a rough stone; rough cloth.
(n.) Not level; having a broken surface; uneven; -- said of a piece of land, or of a road.
(n.) Not polished; uncut; -- said of a gem; as, a rough diamond.
(n.) Tossed in waves; boisterous; high; -- said of a sea or other piece of water.
(n.) Marked by coarseness; shaggy; ragged; disordered; -- said of dress, appearance, or the like; as, a rough coat.
(n.) Hence, figuratively, lacking refinement, gentleness, or polish.
(n.) Not courteous or kind; harsh; rude; uncivil; as, a rough temper.
(n.) Marked by severity or violence; harsh; hard; as, rough measures or actions.
(n.) Loud and hoarse; offensive to the ear; harsh; grating; -- said of sound, voice, and the like; as, a rough tone; rough numbers.
(n.) Austere; harsh to the taste; as, rough wine.
(n.) Tempestuous; boisterous; stormy; as, rough weather; a rough day.
(n.) Hastily or carelessly done; wanting finish; incomplete; as, a rough estimate; a rough draught.
(n.) Produced offhand.
(n.) Boisterous weather.
(n.) A rude fellow; a coarse bully; a rowdy.
(adv.) In a rough manner; rudely; roughly.
(v. t.) To render rough; to roughen.
(v. t.) To break in, as a horse, especially for military purposes.
(v. t.) To cut or make in a hasty, rough manner; -- with out; as, to rough out a carving, a sketch.
Example Sentences:
(1) By 24 hr, rough endoplasmic reticulum in thecal cells increased from 4.2 to 7% of cell volume, while the amount in granulosa cells increased from less than 3.5% to more than 10%; the quantity remained relatively constant in the theca but declined to prestimulation values in the granulosa layer.
(2) Thus, it appears that neuronal loss may account for up to roughly half of the striatal D2 receptor loss during aging.
(3) The cis isomer was retained longer in liver, particularly in mitochondria, but had low retention in that portion of the endoplasmic reticulum isolated as the rough membrane fraction.
(4) The results indicated that roughly 25% of patients treated in this way will become hypothyroid after 5 years and that 85% are cured (need no further therapy during the follow-up period) using a single dose of iodine-131.
(5) This heretogeneity occurred mainly as a progressive, decreasing gradient in the first half of this pathway, between the rough endoplasmic reticulum and the mi-cisternae of the Golgi apparatus.
(6) Electron microscopy revealed a well-developed rough endoplasmic reticulum, an enlarged Golgi apparatus and many highly electron-dense secretory granules resembling those of Clara cells.
(7) Four fractions enriched, respectively, in plasma membrane (PM), smooth endoplasmic reticulum (SER), rough endoplasmic reticulum (RER), and mitochondria were isolated from estrogen-dominated rat myometrium.
(8) For trials in which the target was present in the array, RT functions were roughly symmetric, the shortest RTs being for extreme distractor ratios, and the longest RTs being for arrays in which there were an equal number of each distractor type.
(9) Classic technics of digital image analysis and new algorithms were used to improve the contrast on the full image or a portion of it, contrast a skin lesion with statistical information deduced from another lesion, evaluate the shape of the lesion, the roughness of the surface, and the transition region from the lesion to the normal skin, and analyze a lesion from the chromatic point of view.
(10) Electron microscopic evaluation of microsomal fractions showed elements of the plasma membrane, including cilia and microvilli, as well as rough and smooth endoplasmic reticulum.
(11) The local guide led us down a rough, uneven pathway, talking as he went.
(12) It's the roughly $2bn in revenue grossed by his blockbuster movies, some of which he had to be talked into making.
(13) The interaction between PE and E-IgG involved the extension of micropseudopods toward adherent E-IgG, the formation of a linear uniform cap of roughly 200 A between opposing cell membranes, the ingestion of E-IgG by PE into a membrane-lined compartment, and the disintegration of the ingested ligand into membranous debris.
(14) Ultracentrifugally separated HDL2 and HDL3 roughly corresponded to HDL2e and HDL3e, respectively.
(15) The locations of these 15 insertion sites correlate well with the roughly estimated locations of five of the DNase I-hypersensitive subregions.
(16) The Lords will vote on three key amendments: • To exclude child benefit from the cap calculation (this would roughly halve the number of households affected).
(17) The unique structure we describe is a cytoplasmic organelle which, like annulate lamellae, is closely associated with the endoplasmic reticulum and is presumed to be related to the genesis of rough-surfaced endoplasmic reticulum in tumor cells.
(18) Besides the rough, wrinkled, and brown or black surface of the fingertips, microwrinkles of the epidermis occur on the skin ridges, which have so far not been described.
(19) Ultrastructural examination of noncartilaginous regions of the tumor demonstrated mesenchymal cells with features suggestive of cartilaginous differentiation, viz, scalloped cell membranes, sac-like distension of abundant rough endoplasmic reticulum, and a matrix containing fibrillary and finely granular material.
(20) That, roughly, was the theme of the Wednesday Play, Cathy Come Home, (BBC1) directed by Kenneth Loach, produced by Tony Garnett.