(n.) A colorless liquid resembling phenol or carbolic acid, homologous with pyrocatechin, and obtained from beechwood tar and gum guaiacum.
Example Sentences:
(1) Guaiacol and creosol, the chief constituents of wood creosote, were moderately effective and their respective IC50 values were 0.18 and 0.13 mM.
(2) The typical two-membrane structure of gram-negative bacteria, however, was observed after prefixation with a combination of gluteraldehyde, formalin, and creosol.
(3) Suicide methods were comprised of hanging (51.9%-27 cases), being run over by a streetcar (28.8%-15 cases), drowning (6 cases), jumping off a high building (3 cases) and intoxication by creosol liquid soap (1 case).
(4) Eugenol, guaiacol, and creosol had therapeutic indices much higher than those of other phenolic compounds examined.
(5) Wood creosote, a mixture of guaiacol, creosol, and other related phenolic compounds, suppresses the spontaneous longitudinal phasic contractions of an isolated rat ileal segment.
(6) It was found that 2-methoxy-4-methylphenol (creosol) was more suitable.
(7) Of these, 19 were phenolic compounds, i. e., guaiacol, phenol, two cresol isomers, four methylguaiacol (creosol) isomers, six xylenol isomers, two trimethylphenol isomers, 4-ethylguaiacol, 4-ethyl-5-methylguaiacol, and 4-propylguaiacol.
Cresol
Definition:
(n.) Any one of three metameric substances, CH3.C6H4.OH, homologous with and resembling phenol. They are obtained from coal tar and wood tar, and are colorless, oily liquids or solids. [Called also cresylic acid.]
Example Sentences:
(1) A low-toxic dose of o-cresol (Img) abruptly activates the effect of the same dose of BP (1 mg) according to all parameters (increase of the frequency, coefficient of multiplicity and degree of malignancy of tumours, shortening of the latency period) and somewhat inhibits its activity when administered before or after BP.
(2) The compounds were: anisole, rho-cresol, butylated hydroxytoluene, butylated hydroxyanisole, 2-tert-butyl-4-methylphenol,2,6-di-tert-butyl-4-nitrosophenol and rho-methoxyphenol.
(3) Other analogs, m-cresol, m-ethylphenol, 4-ethylresorcinol, and phloroglucinol, mimic orcinol as effectors, in that they (a) accelerate electron flow from NADH to the flavin and (b) decrease the apparent K-m for NADH but not to the same extent as the substrates that are hydroxylated.
(4) The m-xylene-adapted microorganisms in the aquifer column degraded toluene, benzaldehyde, benzoate, m-toluylaldehyde, m-toluate, m-cresol, p-cresol, and p-hydroxybenzoate but were unable to metabolize benzene, naphthalene, methylcyclohexane, and 1,3-dimethylcyclohexane.
(5) When applied as diagnostic tests for the stagnant loop syndrome, the phenol excretion showed 2 false negative results, the p-cresol excretion 3 false negative and 2 false positive results, and the indican excretion 6 false positive results.
(6) Oxidation of the methyl group to 4-OH-benzaldehyde was catalyzed by p-cresol methylhydroxylase.
(7) In support of the formation of these metabolites, it has been demonstrated that phenobarbital induced rat liver microsomes readily convert 4-methyl-2-cyclohexenone (V) to 4-hydroxy-4-methyl-2-cyclohexenone (VII) and p-cresol (VIII) in the presence of NADPH and O2.
(8) The ring-fission product of catechol was formed from phenol by a fluorescent Pseudomonas, that of 3-methylcatechol was formed from o-cresol and m-cresol, and the ring-fission product of 4-methylcatechol was given from p-cresol.
(9) The separated flavoprotein subunit shows only 2% of the catalytic activity of the original enzyme on p-cresol and is characterized by converging lines in bisubstrate kinetic analysis, while the intact and reconstituted enzymes show parallel line kinetics in steady-state experiments.
(10) The Km for p=cresol 3.6 micron and for p=hydroxybenzyl alcohol, 15 micron.
(11) An additional metabolite, alpha, alpha, alpha-trifluoro-amino-5-nitro-p-cresol (G), accounts for 27% of urine 14C.
(12) Both hippuricuria and o-cresoluria end-of-work-shift values, corrected for creatinine and specific gravity, were significantly related to the mean daily environmental concentration of toluene, the correlation being weaker for o-cresol.
(13) It was concluded, therefore, that metabolically derived cresols are plausible candidates for the neuroexcitatory properties of toluene.
(14) An amperometric biosensor for determination of phenol, cresol, benzoate and 2-methyl-4-chlorophenol using Rhodococcus-cells and enzyme extracts of Rhodococcus has been developed.
(15) p-Cresol may therefore prove more sensitive than indican as an indicator of altered microbial metabolism due to saccharin.
(16) (+)-2,5-Dihydro-4-methyl- and (+)-2,5-dihydro-2-methyl-5-oxo-furan-2-acetic acid were formed in high yield as dead-end catabolites from cooxidation of cresoles.
(17) Phenol and m-cresol were inducers of meta pathway enzymatic activity.
(18) Gas-phase deuterium exchange studies (employing N2H3-DCI MS) of the isolated phenylthiohydantoin (Pth) derivatives of modified residue 13 demonstrate that p-cresol forms two chemically distinct covalent adducts and support the hypothesis that a (4-hydroxyphenyl)methyl radical is generated during catalysis.
(19) In the 4-chloro-m-cresol group, a slight elevation of erythrocytic porphyrins was seen, but the difference was not statistically significant.
(20) Ridgeback prawns formed beta-D-glucosides in small quantities, preferring conjugation of p-nitrophenol and 4-nitro-m-cresol to form sulphates and unknown conjugates through a unique conjugation pathway.