(1) These findings indicate that this animal model is likely to be suitable for the studies of endemic cretinism in man.
(2) The occurrence of congenital deafness, mutism and goitre unassociated with cretinism or mental retardation in euthyroid patients is known as Pendred's Syndrome.
(3) In 1888 cretinism, myxoedema and cachexia strumipriva were attributed to thyroid insufficiency.
(4) A male patient with clinical and radiographic evidence of cretinism was found to have T3 thyrotoxicosis.
(5) Differences between the two types of cretinism may be explained by continuing postnatal thyroid hormone deficiency in the myxoedematous type, which results in impaired growth, skeletal retardation and sexual immaturity.
(6) Furthermore, these data support the hypothesis that the primary pathophysiologic event in the different types of endemic cretinism is represented by maternal and fetal hypothyroidism, while differences may be explained by the extent and duration of postnatal hypothyroidism.
(7) We conclude that the presence of thyroid growth inhibiting immunoglobulin may be related to the absence of thyroid growth or even thyroid atrophy in endemic cretins.
(8) Although this classification highlights the important neurological sequelae of the disorder it implies that myxoedematous cretins have an alternative mechanism.
(9) Our findings have implications for the definition and diagnosis of endemic cretinism.
(10) To study this question we conducted a five-month follow-up of 51 patients with cretinism (age 14 and below), who were randomly assigned to treatment (0.5 ml of intramuscular iodized oil) and control groups.
(11) Nevertheless, all myxedematous cretins had some neurologic disorders (hyperreflexia, increased muscle tone, disorder of gait, Babinski sign, hypoacusia) that were similar to those present in neurologic cretins.
(12) Our data therefore suggest that the different clinical types of endemic cretinism are in fact the same disorder phenotypically modified by the length and severity of postnatal hypothyroidism.
(13) All the cretins were over 35 of age, suggesting a severe iodine deficiency in the past decades, and a progressive improvement of nutritional status resulted in "silent iodine prophylaxis."
(14) Experimental cretinism, induced by daily propylthiouracil treatment starting at birth, caused increased serotonin levels in all brain regions studied.
(15) These findings provide a pathogenic basis for the variable clinical expression of endemic cretinism.
(16) The cause or causes of endemic cretinism are less clear.
(17) Furthermore, all cretins were growth retarded when compared with peers of similar age and race.
(18) Urinary excretion of acid mucopolysaccharides and glycopeptides in the urine of an untreated patient with cretinism were measured before and after thyroid hormone replacement.
(19) Because the neurologic type of EC represents a defined section of the spectrum of iodine deficiency disorders (IDD), the term fetal iodine deficiency disorder (FIDD) rather than cretinism is suggested.
(20) A comparative study of EEG between neurological and myxedematous cretins was carried out in a total of 61 cases.
Cretinous
Definition:
(a.) Having the characteristics of a cretin.
Example Sentences:
(1) These findings indicate that this animal model is likely to be suitable for the studies of endemic cretinism in man.
(2) The occurrence of congenital deafness, mutism and goitre unassociated with cretinism or mental retardation in euthyroid patients is known as Pendred's Syndrome.
(3) In 1888 cretinism, myxoedema and cachexia strumipriva were attributed to thyroid insufficiency.
(4) A male patient with clinical and radiographic evidence of cretinism was found to have T3 thyrotoxicosis.
(5) Differences between the two types of cretinism may be explained by continuing postnatal thyroid hormone deficiency in the myxoedematous type, which results in impaired growth, skeletal retardation and sexual immaturity.
(6) Furthermore, these data support the hypothesis that the primary pathophysiologic event in the different types of endemic cretinism is represented by maternal and fetal hypothyroidism, while differences may be explained by the extent and duration of postnatal hypothyroidism.
(7) We conclude that the presence of thyroid growth inhibiting immunoglobulin may be related to the absence of thyroid growth or even thyroid atrophy in endemic cretins.
(8) Although this classification highlights the important neurological sequelae of the disorder it implies that myxoedematous cretins have an alternative mechanism.
(9) Our findings have implications for the definition and diagnosis of endemic cretinism.
(10) To study this question we conducted a five-month follow-up of 51 patients with cretinism (age 14 and below), who were randomly assigned to treatment (0.5 ml of intramuscular iodized oil) and control groups.
(11) Nevertheless, all myxedematous cretins had some neurologic disorders (hyperreflexia, increased muscle tone, disorder of gait, Babinski sign, hypoacusia) that were similar to those present in neurologic cretins.
(12) Our data therefore suggest that the different clinical types of endemic cretinism are in fact the same disorder phenotypically modified by the length and severity of postnatal hypothyroidism.
(13) All the cretins were over 35 of age, suggesting a severe iodine deficiency in the past decades, and a progressive improvement of nutritional status resulted in "silent iodine prophylaxis."
(14) Experimental cretinism, induced by daily propylthiouracil treatment starting at birth, caused increased serotonin levels in all brain regions studied.
(15) These findings provide a pathogenic basis for the variable clinical expression of endemic cretinism.
(16) The cause or causes of endemic cretinism are less clear.
(17) Furthermore, all cretins were growth retarded when compared with peers of similar age and race.
(18) Urinary excretion of acid mucopolysaccharides and glycopeptides in the urine of an untreated patient with cretinism were measured before and after thyroid hormone replacement.
(19) Because the neurologic type of EC represents a defined section of the spectrum of iodine deficiency disorders (IDD), the term fetal iodine deficiency disorder (FIDD) rather than cretinism is suggested.
(20) A comparative study of EEG between neurological and myxedematous cretins was carried out in a total of 61 cases.