(1) These findings indicate that this animal model is likely to be suitable for the studies of endemic cretinism in man.
(2) The occurrence of congenital deafness, mutism and goitre unassociated with cretinism or mental retardation in euthyroid patients is known as Pendred's Syndrome.
(3) In 1888 cretinism, myxoedema and cachexia strumipriva were attributed to thyroid insufficiency.
(4) A male patient with clinical and radiographic evidence of cretinism was found to have T3 thyrotoxicosis.
(5) Differences between the two types of cretinism may be explained by continuing postnatal thyroid hormone deficiency in the myxoedematous type, which results in impaired growth, skeletal retardation and sexual immaturity.
(6) Furthermore, these data support the hypothesis that the primary pathophysiologic event in the different types of endemic cretinism is represented by maternal and fetal hypothyroidism, while differences may be explained by the extent and duration of postnatal hypothyroidism.
(7) We conclude that the presence of thyroid growth inhibiting immunoglobulin may be related to the absence of thyroid growth or even thyroid atrophy in endemic cretins.
(8) Although this classification highlights the important neurological sequelae of the disorder it implies that myxoedematous cretins have an alternative mechanism.
(9) Our findings have implications for the definition and diagnosis of endemic cretinism.
(10) To study this question we conducted a five-month follow-up of 51 patients with cretinism (age 14 and below), who were randomly assigned to treatment (0.5 ml of intramuscular iodized oil) and control groups.
(11) Nevertheless, all myxedematous cretins had some neurologic disorders (hyperreflexia, increased muscle tone, disorder of gait, Babinski sign, hypoacusia) that were similar to those present in neurologic cretins.
(12) Our data therefore suggest that the different clinical types of endemic cretinism are in fact the same disorder phenotypically modified by the length and severity of postnatal hypothyroidism.
(13) All the cretins were over 35 of age, suggesting a severe iodine deficiency in the past decades, and a progressive improvement of nutritional status resulted in "silent iodine prophylaxis."
(14) Experimental cretinism, induced by daily propylthiouracil treatment starting at birth, caused increased serotonin levels in all brain regions studied.
(15) These findings provide a pathogenic basis for the variable clinical expression of endemic cretinism.
(16) The cause or causes of endemic cretinism are less clear.
(17) Furthermore, all cretins were growth retarded when compared with peers of similar age and race.
(18) Urinary excretion of acid mucopolysaccharides and glycopeptides in the urine of an untreated patient with cretinism were measured before and after thyroid hormone replacement.
(19) Because the neurologic type of EC represents a defined section of the spectrum of iodine deficiency disorders (IDD), the term fetal iodine deficiency disorder (FIDD) rather than cretinism is suggested.
(20) A comparative study of EEG between neurological and myxedematous cretins was carried out in a total of 61 cases.
Idiot
Definition:
(n.) A man in private station, as distinguished from one holding a public office.
(n.) An unlearned, ignorant, or simple person, as distinguished from the educated; an ignoramus.
(n.) A human being destitute of the ordinary intellectual powers, whether congenital, developmental, or accidental; commonly, a person without understanding from birth; a natural fool; a natural; an innocent.
(n.) A fool; a simpleton; -- a term of reproach.
Example Sentences:
(1) Thrasher Mitchell: Then why is that idiot Bernard Hogan-Howe getting a knighthood when his plebby plods tried to stitch me up?
(2) According to Deborah Mattinson, his pollster, Brown " loved slogans and believed them to be imbued with a mystical power capable of persuading the most intransigent voter", and therefore went a bundle on them – not least " A future fair for all ", the surreal dud with which Labour went to the country in 2010, following 2005's equally idiotic " forward not back ".
(3) But cowardly useful idiots of Warwick have banned @MaryamNamazie.” On Sunday night the union released a statement reversing the decision, which it stated had gone against normal procedures.
(4) Aren't the older generation always going to think kids are idiots?
(5) Treating voters like idiots doesn't often work – so the posters with a picture of a sick baby, saying, "She needs a new cardiac facility not an alternative voting system", or of the soldier, reading, "He needs bulletproof vests, not an alternative voting system", must surely be an insult too far to the public's intelligence.
(6) The boss of a successful US hedge fund has quit the industry with an extraordinary farewell letter dismissing his rivals as over-privileged "idiots" and thanking "stupid" traders for making him rich.
(7) Who can complain of physical fear, of the nightmare of a baby eating its way out of your abdomen, of the loss of professional autonomy, staring at a stranger's idiotic grin?
(8) Facebook Twitter Pinterest Michael Flynn in 2016: ‘When you’re given immunity, you’ve probably committed a crime’ – video Vladimir Putin’s Russia is generally regarded as America’s mightiest enemy, however idiotic this might be.
(9) Whatever they'd gone through in the past, they were idiots for not understanding the modern world.
(10) If he was on the verge of becoming a "national treasure" to the minuscule percentage of the nation who could identify him by name were they shown a picture of him, this latest episode will have reminded them that there really are bigger and better idiots in public life to get behind.
(11) This is the most pathetic thing I’ve seen in my whole time in the United States Senate … I think they ought to stop posturing and acting like idiots.” Sean Spicer , the White House press secretary, branded the Democrats’ actions “embarrassing”.
(12) I picture myself at 80, the idiot who did something faddish instead of what people had always done and can never retire.
(13) But it is often said that only an idiot fights a war on two fronts.
(14) April 14, 2015 _Ds73_ (@darkeststar73) @sueperkins complete idiots think they can say what they like, glad we're not all the same !
(15) Many on the Right still view it as the epitome of all that was irresponsible, idiotic and dangerous about the Sixties, while many on the terminally fractured Left still mourn 1968 as the last great moment of revolutionary possibility.
(16) "But she also divides the critics like that other old-school oddball, Norman Wisdom, who was written off as a witless, irritating idiot with a penchant for falling over by some, and seen as a comic genius by others."
(17) "Oh, it says, 'You'll regret this one day, you idiot.'"
(18) 12.25pm: "Björn Lubbers mentioned in his email you posted at 10am that 'the Dutchies are a very friendly, hospitable and tolerant people, but humans will be humans and idiots will be idiots ...', emails Karin Prill.
(19) Every magistrate hears idiotic excuses from stupid criminals, but this is the DWP's unsubtle nudge that all claimants are fraudsters beneath the skin.
(20) I'll be cheering for Germany, and should we advance, hide my Germany-hat as deeply as possible in my backpack on the way home ... the Dutchies are a very friendly, hospitable and tolerant people, but humans will be humans and idiots will be idiots ... my cousin, also living in the Netherlands, is taking off his German license plate off his car and parking it deep inside an underground garage ...