(1) These findings indicate that this animal model is likely to be suitable for the studies of endemic cretinism in man.
(2) The occurrence of congenital deafness, mutism and goitre unassociated with cretinism or mental retardation in euthyroid patients is known as Pendred's Syndrome.
(3) In 1888 cretinism, myxoedema and cachexia strumipriva were attributed to thyroid insufficiency.
(4) A male patient with clinical and radiographic evidence of cretinism was found to have T3 thyrotoxicosis.
(5) Differences between the two types of cretinism may be explained by continuing postnatal thyroid hormone deficiency in the myxoedematous type, which results in impaired growth, skeletal retardation and sexual immaturity.
(6) Furthermore, these data support the hypothesis that the primary pathophysiologic event in the different types of endemic cretinism is represented by maternal and fetal hypothyroidism, while differences may be explained by the extent and duration of postnatal hypothyroidism.
(7) We conclude that the presence of thyroid growth inhibiting immunoglobulin may be related to the absence of thyroid growth or even thyroid atrophy in endemic cretins.
(8) Although this classification highlights the important neurological sequelae of the disorder it implies that myxoedematous cretins have an alternative mechanism.
(9) Our findings have implications for the definition and diagnosis of endemic cretinism.
(10) To study this question we conducted a five-month follow-up of 51 patients with cretinism (age 14 and below), who were randomly assigned to treatment (0.5 ml of intramuscular iodized oil) and control groups.
(11) Nevertheless, all myxedematous cretins had some neurologic disorders (hyperreflexia, increased muscle tone, disorder of gait, Babinski sign, hypoacusia) that were similar to those present in neurologic cretins.
(12) Our data therefore suggest that the different clinical types of endemic cretinism are in fact the same disorder phenotypically modified by the length and severity of postnatal hypothyroidism.
(13) All the cretins were over 35 of age, suggesting a severe iodine deficiency in the past decades, and a progressive improvement of nutritional status resulted in "silent iodine prophylaxis."
(14) Experimental cretinism, induced by daily propylthiouracil treatment starting at birth, caused increased serotonin levels in all brain regions studied.
(15) These findings provide a pathogenic basis for the variable clinical expression of endemic cretinism.
(16) The cause or causes of endemic cretinism are less clear.
(17) Furthermore, all cretins were growth retarded when compared with peers of similar age and race.
(18) Urinary excretion of acid mucopolysaccharides and glycopeptides in the urine of an untreated patient with cretinism were measured before and after thyroid hormone replacement.
(19) Because the neurologic type of EC represents a defined section of the spectrum of iodine deficiency disorders (IDD), the term fetal iodine deficiency disorder (FIDD) rather than cretinism is suggested.
(20) A comparative study of EEG between neurological and myxedematous cretins was carried out in a total of 61 cases.
Imbecile
Definition:
(a.) Destitute of strength, whether of body or mind; feeble; impotent; esp., mentally wea; feeble-minded; as, hospitals for the imbecile and insane.
(n.) One destitute of strength; esp., one of feeble mind.
(v. t.) To weaken; to make imbecile; as, to imbecile men's courage.
Example Sentences:
(1) Infantile delivery also frequently serves to take the curse off self-publicity; sleight of hand for those who find "my programme is on BBC2 tonight" too presumptuous and exposing, and prefer to cower behind the low-status imbecility of "I done rote a fingy for da tellybox!"
(2) By this shape of holidays the partical sphere of the process of training and education, namely the qualification of those oligophren ones in spending an ingenious leisure, should be noticed and contributed to educating those imbecile boys and girls, who are participating their holidays in a camp for their "relative independence*.
(3) Fifty-six patients with cerebral atherosclerosis and epileptiform symptomatology presented an organic defect with signs of lacunar imbecility and atherosclerotic asthenia.
(4) Report on a 5 year old girl with the caracteristic features of the partial trisomy of the short arm of a chromosome no.4: short stature, microcephaly, hydrocephaly, enophthalmus, bulbous nose, deep set malformed ears, hypertrichosis, brachydactyly, hypoplastic ribs, abnormal EEG, imbecility.
(5) "This is imbecilic," said Jean-Yves Oussedik, a historian, puffing his pipe outside the literary cafe Les Deux Magots.
(6) Target London , a folio of 18 posters, bleakly satirised the Thatcher government’s Protect and Survive nuclear attack directives; the critic Richard Cork described the series as the “most hard-hitting attack on government imbecility”.
(7) And there I was, week after week, paid a pittance to jeer at the Smith regime's imbecilities.
(8) It's time to address the public as competent grown-ups and not as imbeciles.
(9) As a late sequelae, there was one patient with intrahepatic block and portal hypertension and one with encephalopathy and imbecility.
(10) Treatment under general anesthesia is inevitably indicated in imbeciles, the feeble-minded, spastics, epileptics, and sometimes in mongoloids.
(11) But before he was a candidate, he was just a visible idiot, and Jon Stewart’s version of him as a knuckle-dragging Queens County imbecile has given us tremendous joy over the years.
(12) The disease had not been diagnosed during life despite imbecility since early childhood and the presence of guiding peripheral symptoms in the form of Pringle's disease.
(13) Meanwhile, because we no longer understand anything unless it is filtered through the prism of the Premier League, various newspapers have already dubbed May's poll " the Wags election " – a classification that underscores the almost infinite creativity of the British media, which have apparently now given up so emphatically that they are content to shoehorn absolutely all human experience into one of four or five pop-cultural tropes, the easier for the voters it apparently regards as imbeciles to understand.
(14) In broadcast interviews, ministers carefully dodge the delivery of any information at all; they would rather sound imbecilic, as if they understood very little and knew even less, than run the risk of having said anything of import.
(15) The differential-diagnostic criteria show the difference of the episodic psychoses of imbeciles from schizophrenias (grafted schizophrenias).
(16) The experience gathered thus far shows that the method presented by the author in his present paper enables the capacity and development of imbecile and abnormality feeble children and juveniles to be diagnosed.
(17) When some highly debile, or imbecile and idiotic children and adolescents refuse to cooperate during the stomatological attendance, the pedopsychiatric consultation fails.
(18) Yet social media is the last remaining British arena in which social mobility flourishes, where imbecilic irrelevances are fast-tracked to positions of extraordinary power by whichever MP or university professor or serious campaigner has decided to give their bile a platform on the news.
(19) Statistically significant differences were established in the values of integrative mark estimations of patients with pronounced debility, of those with mild, medium and profound imbecility.
(20) Patients with pronounced tetrapareses and contractures in all the joints, grave hyperkinesias in all the four extremities, and imbecility were classed with disability group I: those with pronounced para-, hemi-, and tetrapareses, extensive hyperkinesias, combination of the motor disorders with debility were placed into disability group II.