(1) These findings indicate that this animal model is likely to be suitable for the studies of endemic cretinism in man.
(2) The occurrence of congenital deafness, mutism and goitre unassociated with cretinism or mental retardation in euthyroid patients is known as Pendred's Syndrome.
(3) In 1888 cretinism, myxoedema and cachexia strumipriva were attributed to thyroid insufficiency.
(4) A male patient with clinical and radiographic evidence of cretinism was found to have T3 thyrotoxicosis.
(5) Differences between the two types of cretinism may be explained by continuing postnatal thyroid hormone deficiency in the myxoedematous type, which results in impaired growth, skeletal retardation and sexual immaturity.
(6) Furthermore, these data support the hypothesis that the primary pathophysiologic event in the different types of endemic cretinism is represented by maternal and fetal hypothyroidism, while differences may be explained by the extent and duration of postnatal hypothyroidism.
(7) We conclude that the presence of thyroid growth inhibiting immunoglobulin may be related to the absence of thyroid growth or even thyroid atrophy in endemic cretins.
(8) Although this classification highlights the important neurological sequelae of the disorder it implies that myxoedematous cretins have an alternative mechanism.
(9) Our findings have implications for the definition and diagnosis of endemic cretinism.
(10) To study this question we conducted a five-month follow-up of 51 patients with cretinism (age 14 and below), who were randomly assigned to treatment (0.5 ml of intramuscular iodized oil) and control groups.
(11) Nevertheless, all myxedematous cretins had some neurologic disorders (hyperreflexia, increased muscle tone, disorder of gait, Babinski sign, hypoacusia) that were similar to those present in neurologic cretins.
(12) Our data therefore suggest that the different clinical types of endemic cretinism are in fact the same disorder phenotypically modified by the length and severity of postnatal hypothyroidism.
(13) All the cretins were over 35 of age, suggesting a severe iodine deficiency in the past decades, and a progressive improvement of nutritional status resulted in "silent iodine prophylaxis."
(14) Experimental cretinism, induced by daily propylthiouracil treatment starting at birth, caused increased serotonin levels in all brain regions studied.
(15) These findings provide a pathogenic basis for the variable clinical expression of endemic cretinism.
(16) The cause or causes of endemic cretinism are less clear.
(17) Furthermore, all cretins were growth retarded when compared with peers of similar age and race.
(18) Urinary excretion of acid mucopolysaccharides and glycopeptides in the urine of an untreated patient with cretinism were measured before and after thyroid hormone replacement.
(19) Because the neurologic type of EC represents a defined section of the spectrum of iodine deficiency disorders (IDD), the term fetal iodine deficiency disorder (FIDD) rather than cretinism is suggested.
(20) A comparative study of EEG between neurological and myxedematous cretins was carried out in a total of 61 cases.
Stupid
Definition:
(a.) Very dull; insensible; senseless; wanting in understanding; heavy; sluggish; in a state of stupor; -- said of persons.
(a.) Resulting from, or evincing, stupidity; formed without skill or genius; dull; heavy; -- said of things.
Example Sentences:
(1) A series of hierarchical multiple regressions revealed the effects of Surgency, Agreeableness, Conscientiousness, Emotional Stability, and Intellect on evoking upset in spouses through condescension (e.g., treating spouse as stupid or inferior), possessiveness (demanding too much time and attention), abuse (slapping spouse), unfaithfulness (having sex with others), inconsiderateness (leaving toilet seat up), moodiness (crying a lot), alcohol abuse (drinking too much alcohol), emotional constriction (hiding emotions to act tough), and self-centeredness (acting selfishly).
(2) In 1999, Kamprad admitted his past involvement with Nazism in a book about his life and asked for forgiveness for his "stupidity."
(3) Would I be stupid not to wait another six months or so, to get a 90% mortgage given the cons of Help to Buy?
(4) The lucky thing is, says Susan Calman , that although she is "an eternal worrier, occasionally I do something stupid."
(5) "The whole thing was stupid, Donald called him at once to discuss it, he had such a go at him, I mean, fuck, it's a shame we didn't record it, he fucked him up good, had such a proper fucking go at him."
(6) @HunterFelt October 28, 2013 Ali Mason (@alimason) Reassuring to see the #redsox aren't the only ones who can find stupid ways to lose.
(7) But like so many of his colleagues in the Trump administration , Spicer has shown us how unconsciousness and stupidity can, however paradoxically, assume a Machiavellian function – how a flagrant example of gross insensitivity and flat-out odiousness can serve as yet another useful and convenient distraction.
(8) He must have had PR training – didn’t it stretch to not saying stupid stuff?
(9) I’d love to say it’s this big, machiavellian plan, but the main thing to blame is human stupidity,” says Phillip Adcock, author of Shoppology: The Science of Supermarket Shopping.
(10) Barack Obama today phoned the white policeman he said had "acted stupidly" in arresting a black Harvard professor in his own home and invited the officer to visit the White House as the president attempted to defuse a growing race row over the incident.
(11) It’s just one stupid statement after another.” Large crowds of protesters gathered outside the Gyumri base, where Permyakov is now being held, demanding that he be handed over to Armenian law-enforcement to ensure he is prosecuted locally.
(12) And then her drug use got harder, and more desperate, and then it wasn't funny any more; and then, when she was trying to clean up, she was dead, gone to join "the stupid club", as Kurt Cobain's mother described all the rock stars who end up dead at 27.
(13) You've got to have more than that, you've got to make them better players, because players aren't stupid.
(14) Ukip is exploiting the stupidity of ignorant anti-immigrant voters for electoral gain.
(15) I still have a few pints of gin and tonic before I go onstage but nothing stupid."
(16) More here: UK regulator urges banks to speed up swaps mis-selling compensation 8.40am GMT More reaction to the decision to send riot police to evict people from the offices of Greece's former state broadcaster this morning , starting with journalist Nick Malkoutzis: Nick Malkoutzis (@NickMalkoutzis) 5 mths after flicking switch on public broadcaster ERT, gov't tries to settle issue by sending riot police to remove remaining staff #Greece November 7, 2013 Nick Malkoutzis (@NickMalkoutzis) While #ERT will be off air for good after police intervention, the stain of how its closure has been handled won't wash away easily #Greece November 7, 2013 Lady Mondegreen (@amaenad) Like a mean stupid dog appeasing a cruel master, the Greek government wants to lay ERT's limp body at the troika's feet.
(17) The boss of a successful US hedge fund has quit the industry with an extraordinary farewell letter dismissing his rivals as over-privileged "idiots" and thanking "stupid" traders for making him rich.
(18) I think that's a challenge all of us go through, whether it's a parent knowing they are going to have to die and leave their kids behind or it's a young person saying I haven't left my mark yet, I lived for no reason – but that's a stupid way of thinking because as Hazel says in the book there will come a day when Mozart isn't remembered so don't worry about it!
(19) The president should have directed the Justice Department to stop taking stupid points and petty appeals.” One reason the Justice Department pursued the habeas cases so hard was its client: the Pentagon.
(20) More from Behind the joke • James Acaster: 'Normal people perv solo' • Phil Wang: impossibly wise or offensively stupid • Holly Walsh: 'I build my comedy block-by-block like Lego'