(a.) Having the form of a cross; appertaining to a cross; cruciform; intersecting; as, crucial ligaments; a crucial incision.
(a.) Severe; trying or searching, as if bringing to the cross; decisive; as, a crucial test.
Example Sentences:
(1) Therefore, the measurement of the alpha-antitrypsin content plays the crucial part in differential diagnosis of primary (hereditary determined) and secondary (obstructive) emphysema.
(2) At first it looked as though the winger might have shown too much of the ball to the defence, yet he managed to gain a crucial last touch to nudge it past Phil Jones and into the path of Jerome, who slipped Chris Smalling’s attempt at a covering tackle and held off Michael Carrick’s challenge to place a shot past an exposed De Gea.
(3) The agriculture ministry raised the risk level of the virus spreading from moderate to high on Tuesday across the country, at a crucial time for the industry.
(4) Conservative commentators responded with fury to what they believed was inappropriate meddling at a crucial moment in the town hall debate.
(5) Although the performance aspects of electronic displays are crucial considerations in workstation design, experience suggests that human factors in mechanical operation, software accessibility, and workstation environment are also important.
(6) The secretary of state should work constructively with frontline staff and managers rather than adversarially and commit to no administrative reorganisation.” Dr Jennifer Dixon, chief executive, Health Foundation “It will be crucial that the next government maintains a stable and certain environment in the NHS that enables clinical commissioning groups (CCGs) to continue to transform care and improve health outcomes for their local populations.
(7) The results suggest that the ACTH-containing part of the hypothalamus around the PVH is crucially involved in the organization of grooming behaviour.
(8) A functional impairment of the amino acid transport systems at the level of the blood-brain barrier seems to play a crucial role in causing deleterious modifications of the synaptic neurotransmission in the central nervous system.
(9) The cerebral distribution and regulation of excitatory amino acid levels may play a crucial role in neuronal development.
(10) Imagining faces was also the only condition that led to an increase of activity in the left inferior occipital region which has been suggested by previous studies as being a crucial area for visual imagery.
(11) This is the most crucial issue of our time and the people must be heard, not criminalised."
(12) Therefore it is crucial to investigate the role of glucocorticoids in non-pituitary tumours and this requires an understanding of the molecular mechanisms involved in glucocorticoid inhibition of the normal POMC gene in the pituitary.
(13) The agreement, hailed as a "landmark" deal and a breakthrough by politicians and the green lobby alike, came before a crucial EU summit opening in Brussels tomorrow at which 27 prime ministers and presidents are supposed to finalise an ambitious package to cut greenhouse gas emissions by 20% by 2020.
(14) A comparison of the pharmacokinetics as well as the teratogenicity between cyclophosphamide and some specific deuterium-labeled analogues showed that the isotope effect observed can be related to a particular metabolic pathway crucial for teratogenic activation by this drug.
(15) The crucial issue of whether subtle behavioral, intellectual, and developmental impairment occurs in young children, as a result of lead-induced CNS damage is discussed in detail.
(16) The crucial point in all likelihood is the nature of this heme-binding protein.
(17) Standard criteria for staging and response evaluation, including pathologic documentation of remission status, are crucial.
(18) Given that a post-poll economy still registers as a crucial issue among undecided voters, and that matters economic are now his BBC day job, that was hardly surprising.
(19) Overall, these results confirm that the medial septum plays a crucial role in the acquisition of problem solving.
(20) He is joined by Cathy O’Toole, the ALP candidate for the crucial swing seat of Herbert where Rudd’s campaign bus has stopped on Sunday evening.
Essential
Definition:
(a.) Belonging to the essence, or that which makes an object, or class of objects, what it is.
(a.) Hence, really existing; existent.
(a.) Important in the highest degree; indispensable to the attainment of an object; indispensably necessary.
(a.) Containing the essence or characteristic portion of a substance, as of a plant; highly rectified; pure; hence, unmixed; as, an essential oil.
(a.) Necessary; indispensable; -- said of those tones which constitute a chord, in distinction from ornamental or passing tones.
(a.) Idiopathic; independent of other diseases.
Example Sentences:
(1) However, medicines have an important part to play, and it is now generally agreed that for the very poor populations medicines should be restricted to those on an 'essential drugs list' and should be made available as cheaply as possible.
(2) The results of the evaluation confirm that most problems seen by first level medical personnel in developing countries are simple, repetitive, and treatable at home or by a paramedical worker with a few safe, essential drugs, thus avoiding unnecessary visits to a doctor.
(3) Nucleotide, which is essential for catalysis, greatly enhances the binding of IpOHA by the reductoisomerase, with NADPH (normally present during the enzyme's rearrangement step, i.e., conversion of a beta-keto acid into an alpha-keto acid, in either the forward or reverse physiological reactions) being more effective than NADP.
(4) Community involvement is a key element of the Primary Health Care (PHC) approach, and thus an essential topic on a course for managers of Primary Health Care programmes.
(5) No significant fatty acid binding by proteins was detected in S. cerevisiae, even when grown on a fatty acid-rich medium, thus indicating that such proteins are not essential to fatty acid metabolism.
(6) The UK's standard position on ICC indictees is to avoid all contact unless "essential".
(7) In spite of important differences in size, chemical composition, polymer density, and configuration, biological macromolecules indeed manifest some of the essential physical-chemical properties of gels.
(8) Most cis AB sera have anti-B activity, essentially at 4 degrees C. In saliva A and H substances are found in normal amounts but B substance is only evidenced by inhibition of autologous cells agglutination.
(9) Treatment with trypsin gave essentially one radioactive peptide, the active site peptide, of approximately 2300 molecular weight.
(10) We conclude that this enzyme is essentially identical to the native enzyme and should be very useful in the future study of this important hydroxylase.
(11) Thus serum ionized calcium in untreated essential hypertensive patients may predict the blood pressure response to the slow calcium channel blocker verapamil.
(12) The effects of supervised mild aerobic exercise at the work load of the blood lactate threshold for 10 weeks on serum lipids and apolipoproteins were studied in 24 patients with essential hypertension.
(13) No other essential regulatory sequence is located further upstream.
(14) Based on the results of the Community AIM Exploratory Action, further collaborative work is required at EEC level to create an Integrated Health Information Environment (IHE) allowing essentially for integration, modularity and security.
(15) Ovarian vein sampling for androgen was essential in locating this patient's microscopic tumor.
(16) After approximately 20 in vitro passages, Chinese hamster kidney (CHK) cell cultures transformed upon exposure to different strains of SV 40 can show a diploid modal chromosome number of 22 with chromosome counts exclusively or essentially in the diploid range (20-25).
(17) An official from Cafcass, the children and family court advisory service, tried to persuade the child in several interviews, but eventually the official told the court that further persuasion was inappropriate and essentially abusive.
(18) Of 55 new open reading frames analysed by gene disruption, three are essential genes; of 42 non-essential genes that were tested, 14 show some discernible effect on phenotype and the remaining 28 have no overt function.
(19) Essential characteristics of the composite bone cement included a homogeneous and uniform fiber distribution, and a minimal increase in apparent viscosity of the polymerizing cement.
(20) The median blood levels were lower in hyperacidic subjects and higher in hypoacidic patients; the urinary excretion of the digitalis compound showed no essential differences.