(superl.) In its natural state; not cooked or prepared by fire or heat; undressed; not altered, refined, or prepared for use by any artificial process; raw; as, crude flesh.
(superl.) Unripe; not mature or perfect; immature.
(superl.) Not reduced to order or form; unfinished; not arranged or prepared; ill-considered; immature.
(superl.) Undigested; unconcocted; not brought into a form to give nourishment.
(superl.) Having, or displaying, superficial and undigested knowledge; without culture or profundity; as, a crude reasoner.
(superl.) Harsh and offensive, as a color; tawdry or in bad taste, as a combination of colors, or any design or work of art.
Example Sentences:
(1) Life expectancy and the infant mortality rate are considered more useful from an operational perspective and for comparisons than is the crude death rate because they are not influenced by age structure.
(2) While the reduced form of the "derived" polyphenolic compounds, generated during tissue homogenization, appeared to enhance dye binding with bovine serum albumin, their influence on the protein assay directly in crude homogenates was extremely diverse.
(3) Slight cross-reactivity was apparent when crude preparations of cellular or culture filtrate antigens, used in this laboratory to detect antibodies to Candida albicans, Coccidioides immitis and Cryptococcus neoformans, were probed with hyperimmune rabbit antisera to A. fumigatus.
(4) The crude survival rate at 5 years was 83.3% (age-adjusted 96%), and at 10 years 53.8%).
(5) VS had a crude topography, and receptive fields of neurons in VS were relatively large.
(6) With [125I-Tyr11]SRIF as a radiolabeled ligand, the specific ligand binding to crude membrane increased transiently in the early phase of postnatal development and then decreased.
(7) Dialyzed crude enzyme extracts from yeast cells were found to destroy diacetyl in a manner quite similar to that of diacetyl reductase from Aerobacter aerogenes, and both the bacterial and the yeast extracts were stimulated significantly by the addition of reduced nicotinamide adenine dinucleotide (NADH).
(8) A crude extract of Brucella melitensis was obtained by sonication, centrifugation and dialysis, and analyzed by quantitative immunoelectrophoresis.
(9) These results indicate that countercurrent distribution of crude extracts in aqueous two-phase systems is a useful method to study protein-protein interaction.
(10) Optimal myocyte cultures were obtained using serial 0.2% crude trypsin digestions of hearts from 1-2-day-old rats.
(11) Their defect in DNA degradation was shown not only after treatment by toluene but also in crude extracts after cell disintegration by ultrasonic and in untreated starved cultures.
(12) On subfractionation of this crude mitochondrial fraction with continuous sucrose density gradients, most of the activity of the three enzymes was found at a higher density than NAD+-isocitrate dehydrogenase and at about the same density as glutamate dehydrogenase, confirming earlier reported data for acetyl-CoA synthase.
(13) A crude membrane fraction derived from the mutant is unable to synthesize cardiolipin from phosphatidylglycerol in vitro.
(14) DNA membrane complexes from sucrose gradients, as well as the crude M-band preparation and a non-membrane-associated DNA fraction from nuclei can synthesize DNA in vitro without the addition of an external DNA template or DNA polymerase.
(15) Specificity of [125I]hCG binding to other tissues was determined by incubating crude membrane preparations of heart, skeletal muscle, liver, and kidney.
(16) Binding experiments of cyclic AMP on crude extract of dog thyroid lead to the conclusion that the maximal capacity of the specific binding site is close to the cyclic AMP content in resting thyroid cells.
(17) Interaction between these acceptor sites and crude or partially purified estradiol receptor shows a high association constant (over 10(9) M).
(18) The extent of sialomucin adjacent to a primary colorectal cancer does provide a crude assessment of tumour invasiveness and risk of local recurrence.
(19) Effects of 4-aminomethyl-1-benzylpyrrolidin-2-one-hemifumarate (WEB 1881 FU), a novel pyrrolidinone nootropic, on acetylcholine (ACh) receptors and adrenoceptors were investigated using crude membranes of the rat brain.
(20) By immunoaffinity chromatography using the immunoadsorbent, approximately 25% of crude enterotoxin applied was recovered in the eluate.
Stark
Definition:
(n.) Stiff; rigid.
(n.) Complete; absolute; full; perfect; entire.
(n.) Strong; vigorous; powerful.
(n.) Severe; violent; fierce.
(n.) Mere; sheer; gross; entire; downright.
(adv.) Wholly; entirely; absolutely; quite; as, stark mind.
(v. t.) To stiffen.
Example Sentences:
(1) World leaders must reach a historic agreement to fight climate change and poverty at coming talks in Paris, facing the stark choice to either “improve or destroy the environment”, Pope Francis said in Africa on Thursday.
(2) Facebook Twitter Pinterest No shake: Donald Trump snubs Angela Merkel during photo op The piece of pantomime was in stark contrast to the visit of Theresa May in January.
(3) But as a former Eurocrat, he is well-versed in the weaknesses and believes it is right to highlight them in stark language.
(4) These achievements, and faults, will find stark contrast with Trump’s administration; certainly Trump’s nominations for key positions in his cabinet that relate to climate change have prompted alarm by experts and campaigners.
(5) An ethnic breakdown of other opinion-formers, from book reviewers to theatre critics, would be just as stark.
(6) Paul*, from Essex, a father of two daughters, has experienced those starkly differing standards.
(7) Friends of the Earth's executive director, Andy Atkins, said: "We can't continue to ignore the stark warnings of the catastrophic consequences of climate change on the lives and livelihoods of people across the planet.
(8) She went on to deliver a stark warning that leaving the single market would deter international investors from Britain and lead major companies to question whether they should relocate to mainland Europe.
(9) This was in stark contrast to my comprehensive school.
(10) Their differences highlight Northern Ireland’s often stark dichotomy between religious-based social conservatism and secular progressive liberalism.
(11) By global city standards even those are quite clean and orderly, but compared with the rest of the city they offer a stark contrast.
(12) Dig deeper into the funding numbers – the real story of national politics in the post Citizens United age – and the Tea Party realignment of the GOP stands out yet more starkly.
(13) The inequalities that have been allowed to emerge in this one street are so stark they recall an era as long past as the period of its houses.
(14) A glance at today's Sun provides a stark reminder that constitutional reform is no way to win easy plaudits from the papers that most voters read.
(15) Although the Kyoto agreement only measures production, the stark difference in the figures highlights a key controversy in negotiations about a new treaty – which will continue at a big UN meeting in Cancún, Mexico, in December : some developing countries, such as China, argue they should not be held responsible for emissions generated by consumption in rich nations.
(16) It is a stark contrast to expectations before the vote to leave the EU, when the next move in interest rates was seen as likely to be upwards.
(17) The next few days may well determine whether, this time, such loyalty will be in vain; but, while yearning for a clarion call and what was described as "vision" in this paper's leading article yesterday, I need to pose some pretty stark questions to Guardian readers.
(18) They included Lena Heady (Queen Cersei Lannister), Kit Harington (Jon Snow), Conleth Hill (Lord Varys), Rose Leslie (Ygritte), 17-year-old Maisie Williams (Arya Stark) and 18-year-old Sophie Turner (Sansa Stark).
(19) The orderly village of Agulodiek in Ethiopia's western Gambella region stands in stark contrast to Elay, a settlement 5km west of Gambella town, where collapsed straw huts strewn with cracked clay pots lie among a tangle of bushes.
(20) The next three years of negotiations on the treaty will be the hardest in the 20-year history of climate change talks because the world has changed enormously since 1992, when the UN convention on climate change was signed, and 1997, when the Kyoto protocol enshrined a stark division between developed countries – which were required to cut emissions – and developing countries, which were not.