(a.) Burdensome or hindering, as a weight or drag; embarrassing; vexatious; cumbrous.
(a.) Not easily managed; as, a cumbersome contrivance or machine.
Example Sentences:
(1) Since this derived formula is very cumbersome to manipulate, tables have been prepared with computer assistance to read the estimated fetal weight directly.
(2) Determination of right ventricular ejection fraction and volumes from radionuclide studies is cumbersome and is subject to considerable methodologic error.
(3) Downing street – aware of the anguish of the families of these unconfirmed Britons – has privately expressed frustration at the cumbersome process of identification of the bodies following the killings last Friday.
(4) Methodological improvements of the stool smear assay may provide a substantially simplified method for the otherwise cumbersome identification of ETEC.
(5) The apparatus is drawn so that plastic sheets serve as substitutes for the elaborate, but cumbersome and unnecessary, locking systems mounted on all the commercial blotters.
(6) However, using standard methods, processing large numbers of samples for immunofluorescence is cumbersome and difficult.
(7) The conventional Marbrook culture system has several disadvantages; the preparation and assembly of the chambers is time consuming, the size of the culture vessels limits the number of replicates that may be set up, and placing the cells in the inner chamber is a cumbersome and slow process.
(8) However, advances in robotic sample preparation may allow the more cumbersome solid-phase isolation or extraction techniques to be used to improved sample throughput and specificity.
(9) The popular systems of classifying DRUJ disorders are based on etiology and treatment, but this approach has inspired schemes that are cumbersome, redundant, and incomplete.
(10) The EU must be able to act with the speed and flexibility of a network, not the cumbersome rigidity of a bloc.
(11) In the meantime, it is possible to evidence some features, sometimes shared with other species if taken separately, which in the whole characterize the epididymis in Equidae: the presence in principal cells of intranuclear inclusions and peculiar small granules in the basal cytoplasmic edge; the organization of groups of cells, likely to be principal ones, in such a way as to constitute intraepithelial crypts; a cumbersome presence of lipofuscinic matter all along the epithelium.
(12) HLA-DP typing using the Primed Lymphocyte Test (PLT) is a long and cumbersome technique requiring DP sensitized clones and bulk reagents.
(13) The main objections of seeking consent are as follows: it would be too cumbersome to obtain consent; if any patients witheld consent, prevalence studies would be less accurate; testing blood samples anonymously and without consent is an acceptable hospital practice; consent for such tests is not legally necessary; consent may be implied from the consent given to have blood taken; the consent requirement may be ignored in minor procedures; and there is no need for consent because testing could not harm anyone.
(14) A method is described in which a simple disposable plastic umbilical cord clamp replaces the traditional cumbersome instrument or expensive staples in the operation of end colostomy.
(15) Fenech said the multilayered, cumbersome intelligence apparatus was like an army of soldiers wearing lead boots.
(16) The usefulness of this parameter is reduced because of the cumbersome calculations required to determine the time within which an arterial pulse wave conducted via the arteriovenous anomaly reaches the jugular vein.
(17) Such systems are unable to reach a correct diagnosis quickly and often subject the user to a cumbersome dialogue.
(18) The overwhelming priority is to improve our financial and operating performance, improve our speed and response to events and improve internal controls.” East did not go into details about potential job cuts, business disposals, or exiting certain countries, but he said large layers of cumbersome bureaucracy needed to be stripped away so the company could function properly and respond to market changes.
(19) The patient is placed directly on this box, which makes the methods less cumbersome and more suitable for routine use.
(20) The 2-hr continuous measurement is, however, too long for a clinical examination and the 24-hr repeat measurement cumbersome.
Difficulty
Definition:
(n.) The state of being difficult, or hard to do; hardness; arduousness; -- opposed to easiness or facility; as, the difficulty of a task or enterprise; a work of difficulty.
(n.) Something difficult; a thing hard to do or to understand; that which occasions labor or perplexity, and requires skill and perseverance to overcome, solve, or achieve; a hard enterprise; an obstacle; an impediment; as, the difficulties of a science; difficulties in theology.
(n.) A controversy; a falling out; a disagreement; an objection; a cavil.
(n.) Embarrassment of affairs, especially financial affairs; -- usually in the plural; as, to be in difficulties.
Example Sentences:
(1) Technical factors that account for increased difficulty in these patients include: problems with guide catheter impaction and ostial trauma; inability to inflate the balloon with adequate guide catheter support; and need for increased intracoronary manipulation.
(2) To overcome this difficulty, a "hetero-antibody" RIA was studied.
(3) Epidemiological studies on low risks involve a number of major methodological difficulties.
(4) Mild swallowing difficulties occurred in 18 patients (39%), moderate dysfunction in 23 (50%), and severe dysfunction in five (11%).
(5) Reasons for non-acceptance do not indicate any major difficulties in the employment of such staff in general practice, at least as far as the patients are concerned.
(6) Spontaneous reports of suspected adverse reactions may be the only way of revealing very rare events but they present great difficulties of rational interpretation.
(7) The indication of the DNA probe method would be considered in the four cases as follows, 1. necessity of the special equipment to isolate the pathogen, 2. necessity of the long period to isolate the pathogen, 3. existence of the cross reaction among the pathogen and relative organisms in the immunological procedure, 4. existence of the difficulty to identify the species of the pathogen by the ordinary procedure.
(8) The 1-0-methylalduronic-acidmethylesters, obtained by the methanolysis of the polysaccharides, are reduced with boronhydrid to the corresponding methyl glycosides; there are split with acid to the aldoses, which are converted in pyridine with hydroxylamine to the aldoximes and than with acetic anhydride to the aldonitrilacetates, which can be separated by gaschromatography without difficulty.
(9) A control experiment demonstrated that changes in general arousal could not account for the effects of task difficulty on neuronal responses.
(10) In the anatomy laboratory we looked for an alternative approach to the glenohumeral joint which would accommodate these difficulties.
(11) A 27-year-old lady presented with history of discomfort in the throat and difficulty in swallowing for two weeks.
(12) Especially in the old patients (over 70 years) the incisional hernias represents an invalidating pathology whose treatment, for the high incidence of associated diseases of respiratory and cardiocirculatory apparatus in the aged, offers difficulties connected both to surgical methods and to the perioperative evaluation and preparation of patients.
(13) Marked pain and great difficulty in introducing the apparatus made its use limited in respectively 15% and 14.5% of cases.
(14) The tasks which appeared to present the most difficulties for the patients were written spelling, pragmatic processing tasks like sentence disambiguation and proverb interpretation.
(15) In favorable cases, tRNA-DNA hybrids of length about 80 nucleotide pairs can be recognized (although with difficulty).
(16) The patient with the right posterior lesion could not recognize handwriting, was prosopagnosic and topographagnosic, but had no difficulty in reading, lipreading, or in recognizing stylized drawings.
(17) A review of the literature summarises the difficulties of diagnosis.
(18) The major difficulty encountered with the current technique is the danger of neurologic injury during the passage and handling of conventional wires, especially in extensive procedures.
(19) However six equivocal studies were observed in profoundly jaundiced patients with bilirubin levels above 400 mumol l-1 due to difficulties in differentiating extrahepatic obstruction from severe intrahepatic cholestasis.
(20) While mindful of the potential difficulties which attend its introduction into the treatment situation there is an attempt to balance this position through a consideration of the appropriate conditions and modes of operation under which a humor-enriched approach may be efficacious.