(1) As an inspiratory monitor in the curarized patient, the sensor responds quantitatively to persisting spontaneous tidal volumes of 1 ml.
(2) Protamine sulphate in vitro antagonized anticoagulant properties but did not protect mice from toxic envenomation; because venom was also neurotoxic and showed a curare like effect at the neuromuscular junction.
(3) Specificity of the assay for nicotinic receptors was confirmed by the relative abilities of the following compounds to prevent 125I-BGT binding: curare greater than or equal to nicotine greater than hexamethonium greater than atropine.
(4) Ca2+-ATPase of rats and rabbits skeletal muscle sarcolemma was studied as affected by relaxants: tubocurarine, myorelaxin and dioxonium, and by anesthetic fluothane in experiments in vitro and in vivo with lung artificial ventilation during curarization.
(5) In decorticate and in spinal curarized rabbit preparations, respiratory and locomotor rhythms can be closely related (1:1 coupling between successive periods), demonstrating central relationships between the two types of pattern generators.
(6) When the interaction of these two agents is being evaluated it is important to consider the doses of the agents, the stage of curarization where the interaction took place and the method of assessing the neuromuscular blockade.
(7) The effect of curare on the amount of transmitter released by a nerve stimulus was studied in frog and rat nerve-muscle preparations using electrophysiological techniques.2.
(8) The root bark of S. paludosum which showed curare like activity yielded tomatidenol and another yet unidentified alkaloid responsible for the biological activity.
(9) The relationship between the therapeutic doses and the curarizing doses had a greater margin of security with the three antibiotics than with streptomycin.
(10) The agents could be divided into 4 classes: (1) agents having no effect upon transmission at this cholinergic junction; (2) agents of a class typified by curare, which depressed all EPSPs of a train to the same extent, and which are believed to be acting in this system solely as competitive postsynaptic blockers; (3) agents typified by acetylcholine and carbachol (ACh class), which selectively depressed earlier EPSPs of a train more than later EPSPs and which appear to act by reducing the fractional release of transmitter; (4) agents typified by trimethidinium (trimethidinium class), which selectively depress later EPSPs of a train more than earlier EPSPs and which appear to act by reducing the rate of transmitter supply into the readily releasable pool.
(11) Denervation produced by mechanically removing the neurite from the muscle cell also produced similar hyperpolarization, and curarization after denervation was without significant hyperpolarizing effect.
(12) The discovery of the safety margin of neuromuscular transmission has brought forth the requirement for an improvement in the clinical examination of curarization, since the safety margin, i.e.
(13) This non-quantal ACh release is revealed by the hyperpolarization of the muscle membrane following extracellular application of curare or alpha-bungarotoxin, as well as by denervation of the muscle cell.
(14) The 125I-alpha-Bgtx binding is inhibited by curare, decamethonium, hexamethonium but not by carbamylcholine and Naja naja siamensis alpha-toxin and P15 toxin.
(15) Furthermore, because the doses of curare used inhibit motor activity by more than 80%, the fetal transition can occur in the absence of normal levels of motor activity.
(16) The binding was prevented by pretreatment of sperms and activated eggs with 10 nM native alpha-BuTx and 10 microM curare.
(17) According to our experience, the response to carotid body stimulation with cyanide, in normal breathing dogs, consists in hyperpnoea, bradycardia with arterial blood pressure fall (by means of longer diastolic periods), followed by a marked rise in arterial blood pressure and heart rate, after curarization.
(18) The influence of stimulation of stria terminalis and midbrain central gray substance on the neuronal activity of the lateral hypothalamus was studied in acute experiments on curarized rats.
(19) Motor axons can form sprouts from their terminal arborizations in response to partial denervation, and when exposed to pharmacological blocking agents like TTX, botulinum toxins alpha-bungarotoxin, or curare.
(20) Magnetically carried microspheres were used to investigate whether the curare-like drugs can be selectively transported to the muscles of one of the limbs of the cat.