(n.) That part of a pedestal included between the base and the cornice (or surbase); the die. See Illust. of Column.
(n.) In any wall, that part of the basement included between the base and the base course. See Base course, under Base.
(n.) In interior decoration, the lower part of the wall of an apartment when adorned with moldings, or otherwise specially decorated.
Example Sentences:
(1) DNA double strand breaks were observed in the dAdo treated cells 12 hr after the administration.
(2) dAdo toxicity could be prevented in MM96L by addition of the other three deoxynucleosides together but not by removing dAdo after a brief (2 hr) treatment.
(3) The number of viable cells at day 4 increased from 13.7% to 41.1% with the addition of 5 mM nicotinamide, and to 28.8% with 5 mM 3-aminobenzamide added with dCF and dAdo.
(4) On gel electrophoresis, both dCyd and dAdo phosphorylating activities comigrated, indicating that the activities are associated with the same protein.
(5) 2-Cl-dAdo had similar cytotoxic effects at a 0.1 microM concentration.
(6) The present studies with intact human erythrocytes demonstrate that nucleoside analogues which inhibit SAH-hydrolase caused substantial attenuation of adenine transfer from dAdo into ATP.
(7) However, when these special conditions were followed, oligomeric DNA containing 8-oxo-dGuo and 8-oxo-dAdo residues could be prepared in excellent yield.
(8) Deoxyadenosine (dAdo) and deoxyguanosine (dGuo) decrease methionine synthesis from homocysteine in cultured lymphoblasts; because of the possible trapping of 5-methyltetrahydrofolate this could lead to decreased purine nucleotide synthesis.
(9) dAdo and ddAdo were phosphate acceptors and dAMP was a donor.
(10) In medium supplemented with deoxycoformycin, a tight binding ADA inhibitor, dAdo retarded DNA rejoining in a dose and time dependent manner.
(11) Inhibition of LMC by Ado appears to be related to increases in lymphocyte cAMP levels, while the mechanism of action of dAdo remains obscure.
(12) Therefore, it is proposed that the presence of dAdo dThd affects the rate of insertion of repair patches but not the total amount of synthesized and inserted patches.
(13) Approximately two logs of human bone marrow T cells were removed by 24 h of incubation with dCf and dAdo at doses that preserved colony-forming ability of the treated marrow.
(14) Photograph: David Levene for the Guardian Curators: Sébastien Martinez Barat, Bernard Dubois, Sarah Levy, Judith Wielander A simple white dado rail skirts the edge of one room, branching off to form the silhouettes of a line of chairs pushed against the wall.
(15) In sum, we report here three T-cell lines of different phenotypes that displayed significantly different sensitivities to dAdo plus dCoF which may facilitate investigations on the mechanisms of ADA deficiency.
(16) 9-(2'-Deoxy-2'-fluoro-beta-D-arabinofuranosyl)adenine (2'-F-araA) was the only compound to show an incorporation pattern similar to that observed with dAdo by forming analog triphosphate only in the B cell-enriched lymphocyte population.
(17) The near-UV-induced photoreaction of the bifunctional 8-methoxypsoralen (8-MOP) with 2'-deoxyadenosine (dAdo) was investigated in the dry state.
(18) Expression of dAXP catabolic activity in T X B hybrids behaved as a dominant mechanism, conferring resistance to dAdo- and dAdo-related nucleosides to T X B hybrids.
(19) Our studies confirm that CEM avidly accumulates dAXP from dAdo but does not catabolize intracellular dAXP.
(20) To explore the basis for this phenomenon, we have assessed the effects of dAdo and other deoxynucleosides on the repair of gamma-radiation induced DNA strand breaks in resting normal lymphocyte cultures.
Lower
Definition:
(a.) Compar. of Low, a.
(a.) To let descend by its own weight, as something suspended; to let down; as, to lower a bucket into a well; to lower a sail or a boat; sometimes, to pull down; as, to lower a flag.
(a.) To reduce the height of; as, to lower a fence or wall; to lower a chimney or turret.
(a.) To depress as to direction; as, to lower the aim of a gun; to make less elevated as to object; as, to lower one's ambition, aspirations, or hopes.
(a.) To reduce the degree, intensity, strength, etc., of; as, to lower the temperature of anything; to lower one's vitality; to lower distilled liquors.
(a.) To bring down; to humble; as, to lower one's pride.
(a.) To reduce in value, amount, etc. ; as, to lower the price of goods, the rate of interest, etc.
(v. i.) To fall; to sink; to grow less; to diminish; to decrease; as, the river lowered as rapidly as it rose.
(v. i.) To be dark, gloomy, and threatening, as clouds; to be covered with dark and threatening clouds, as the sky; to show threatening signs of approach, as a tempest.
(v. i.) To frown; to look sullen.
(n.) Cloudiness; gloominess.
(n.) A frowning; sullenness.
Example Sentences:
(1) These factors might account for the lower systemic bioavailability of these compounds.
(2) Patients with papillary carcinoma with a good cell-mediated immune response occurred with much lower infiltration of the tumor boundary with lymphocyte whereas the follicular carcinoma less cell-mediated immunity was associated with dense lymphocytic infiltration, suggesting the biological relevance of lymphocytic infiltration may be different for the two histologic variants.
(3) In this study of ten consecutive patients sustaining molten metal injuries to the lower extremity who were treated with excision and grafting, treatment with compression Unna paste boot was compared with that with conventional dressing.
(4) Propranolol resulted in a significantly lower mean hourly, mean 24 h and minimum heart rate.
(5) Homozygotes have sparse greasy fur and lower viability and fertility than normal littermates.
(6) LHRH therapy leads to higher plasma LH levels and a lower FSH in response to an intravenous LHRH test.
(7) On the other hand, the LAP level, identical in preterms and SDB, is lower than in full-term infants but higher than in adults.
(8) It is suggested that the Japanese may have lower trabecular bone mineral density than Caucasians but may also have a lower threshold for fracture of the vertebrae.
(9) Spontaneous locomotor activity was lower in naloxone-infused rats on day 3 only.
(10) After 55 days of unrestricted food availability the body weight of the neonatally deprived rats was approximately 15% lower than that of the controls.
(11) There is no evidence that health-maintenance organizations reduce admissions in discretionary or "unnecessary" categories; instead, the data suggest lower admission rates across the board.
(12) The rate of accumulation of degraded LDL products was lower in collagen gel cultures, but the final levels achieved were the same in the two substrata.
(13) [Ca2+]i exhibited a sigmoidal dependence on [Na+]o. Mg2+, a competitive inhibitor of Na2+-Ca2+ antiport in these cells, antagonized the increase in [Ca2+]i produced by lowering [Na+]o.
(14) Side effect incidence in patients treated with the paracetamol-sobrerol combination (3.7%) was significantly lower than that observed in subjects treated with paracetamol (6.1% - P less than 0.01), salicylics (25.1% - P less than 0.001), pyrazolics (12.6% - P less than 0.001), propionics (20.3%, P less than 0.001) or other antipyretics (17.9% - P less than 0.001).
(15) These findings suggest that clonidine transdermal disks lower blood pressure in hypertensive patients, but produce local skin lesions and general side effects.
(16) Diltiazem monotherapy effectively lowered blood pressure in 60% of patients at 8 weeks.
(17) Thus, our study confirmed that male subjects with a history of testicular maldescent have an increased risk for testis cancer, although the magnitude of this risk was lower than suggested previously.
(18) Anesthetized sheep (n = 6) previously prepared with a lung lymph fistula underwent 2 hr of tourniquet ischemia of both lower limbs.
(19) Nicardipine lowered systolic and diastolic blood pressure to normal, plasma aldosterone was reduced and serum potassium levels were increased.
(20) The overall recoveries of activated ER following chromatography on DEAE-cellulose were significantly lower than the recoveries of the nonactivated ER, 71 and 85%, respectively.