(1) In general, optimal DAGAT activity in vitro was observed when long-chain unsaturated acyl-CoAs and diacylglycerols (DAGs) containing long acyl chains were used as substrates for in vitro TAG synthesis (although 1,2-didecanoin was also very effective).
(2) Incubation of microsomes with CDP-DAG of different fatty acid composition results in quantitative and qualitative differences in lysoPI formation.
(3) We now report that two synthetic diacylglycerols (DAG) replicate the stimulatory and inhibitory effects of TPA on frog skin.
(4) The distribution of PKC returned to control values by 24 h. High glucose did not stimulate phosphoinositide hydrolysis, as evidenced by the absence of an increase in the water-soluble inositol phosphates, indicating that DAG was not generated through the action of a phosphoinositide-specific phospholipase C. Cells treated with the cell-permeable DAG analogue 1-oleoyl-2-acetyl glycerol to activate PKC displayed approximately two-fold increases of fibronectin, laminin, and type IV collagen mRNA levels after normalization against actin.
(5) We observed a 30-45% increase in DAG in rat gastrocnemius and diaphragm muscles, 5-15 min after intramuscular or intravenous injections of 1-3 U of insulin per rat, doses which would be expected to activate insulin receptors more fully.
(6) Concomitantly, an increase of inositol phosphates and diacylglycerol (DAG) production was observed.
(7) The accumulation of [14C]C20:4-DAG (lower in ET than in saline-infused rats) was paralleled by a decrease in phosphatidylinositol (PI) labelling, whereas phosphatidic acid showed a transient increase by 5 min in saline- but not in ET-infused rats.
(8) To determine the role of the DAG produced upon bombesin stimulation, we examined the effects of another activator of protein kinase C, the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA).
(9) It is concluded that carbachol increases [Ca2+]i by facilitating Ca2+ entry through L-type Ca2+ channels via a 1,2-diacylglycerol (DAG)-protein kinase C (PKC)-dependent pathway while quisqualate mobilizes Ca2+ from inositol 1,4,5-trisphosphate (IP3)-sensitive stores.
(10) In order to characterize the properties of the glyceroglycolipid membranes, ESR spectroscopic studies were carried out with an acyl spin-labeled galactosyl ceramide (SL-GC) or a headgroup spin-labeled phospholipid (SL-6-DPPA) in 1,2-dipalmitoyl[beta-cellobiosyl-(1'---3)]glycerol (Cel-DAG) liposomal membranes.
(11) The E. coli dgkA locus which contains the coding sequences for DAG kinase was subcloned into an eukaryotic expression vector, pMT2.
(12) The mean residence time for pharmacologically active molecules in the body was six times shorter for DAG (1.9 hr) than for DBD (11.4 hr).
(13) These data suggest that PKC is a mediator in the generation of DAG.
(14) These results suggest that DAG accumulation is involved in the potentiating effect of A23187 on CCh-stimulated amylase secretion.
(15) It is concluded that insulin-dependent PDH activation, PIG hydrolysis, and IG and DAG generation are mediated by the wild-type but not by the mutated insulin receptor of Val996.
(16) Since most alloantibodies detected only by 2SP-IAT or LISS-DAG were of doubtful clinical significance, and these techniques produced a high number of unwanted positive reactivities, we conclude that 2SP-IAT and LISS-DAG are not appropriate for the pretransfusion screening for unexpected antibodies.
(17) 261, 8597-8600), lipase from Rhizopus arrhizus selectively degraded the 1-acyl-containing species (DAG), but the ether lipid (EAG) was resistant and was identified and quantified after thin layer chromatography separation.
(18) 1-Oleoyl-2-acetylglycerol, a synthetic DAG analog, stimulated endothelial cell DNA synthesis in a concentration-dependent manner.
(19) Whereas DPG and DS are stable at physiological pH, DAG is unstable, undergoing hydrolysis (regeneration of DF) and rearrangement (intramolecular acyl migration to the 2-, 3- and 4-O-acyl-positional isomers).
(20) Addition of PRL to hepatocyte cultures significantly increased [3H]-glycerol incorporation into DAG within 5 minutes which was followed by a loss of cytosolic PKC activity by 10 minutes.
Dragging
Definition:
(p. pr. & vb. n.) of Drag
Example Sentences:
(1) Northern Ireland will not be dragged back by terrorists who have nothing but misery to offer."
(2) Considerate touches includes the free use of cruiser bicycles (the best method of tackling the Palm Springs main drag), home-baked cookies … and if you'd like to get married, ask the manager: he's a minister.
(3) In Belfast, the old quarrels just look likely to drag on in their old familiar way.
(4) Two officers who witnessed the shooting of unarmed 43-year-old Samuel DuBose in Cincinnati will not face criminal charges, despite seemingly corroborating a false claim that DuBose’s vehicle dragged officer Ray Tensing before he was fatally shot.
(5) Finally, it examines Brancheau's death, which played out in front of a crowd, many of whom did not fully understand what was going on as the experienced trainer was dragged under water and flung around the tank.
(6) The longer the problem drags on, the less likely it is we get off lightly," he told the paper.
(7) "Those shows are genuinely moving us forward as an industry, they are dragging the rest of us behind," he says.
(8) Facebook Twitter Pinterest Neighbor Olga Ennis: ‘I watched them drag his body out of the house.
(9) I’m staying in a mobile home called a njalla , designed by artist and architect Joar Nango, which sits on wooden skis that allow you to drag it to a spot of your choosing.
(10) People were holding on to him, trying to pull themselves up by his belt, but only succeeded in dragging him into the water.
(11) The poor trade data indicate that net trade was an appreciable drag on GDP growth in the third quarter and was a major factor why expansion did not come in as high as 1.0% quarter-on-quarter as had seemed possible at one point.
(12) In PT (a) large extracellular markers are dragged by water flow indicating extracellular solute-water interaction, (b) transepithelial Pos is much higher than transcellular Pos.
(13) Consider the open joke that was the repeated European bank stress tests ; the foot-dragging of the central bankers to quell financial panic; the IMF report last week showing that even if Greece took the troika’s medicine it would still be lumbered with “unsustainable” debt .
(14) Tractional water resistance (drag, D, N) was also measured in the same range of speeds.
(15) If you stand on the main pedestrian drag, Ferhadija, and look east, you could be in Istanbul or Cairo.
(16) It would be a mistake to rush it.” But, while revealing disappointing trading figures for the Christmas period and a gloomy outlook for 2017 , Wolfson said he did not think Brexit jitters were stopping people from shopping: “It is more the fact that incomes are likely to be squeezed.” Next's gloomy 2017 forecast drags down fashion retail shares Read more Wolfson was one of a handful of senior business leaders to openly back Brexit but has said in the past that the referendum vote was about UK independence, not isolation, and the country should be aiming for “an open, global-facing economy”.
(17) The brothers said they were pleased that after “a great deal of dragging of their heels” the Mail and Hopkins had accepted the allegations were false.
(18) With the cultures of mycoplasmas obtained from the eyes of human patients suffering from sympathetic ophthalmia, it was possible to produce the same symptoms in chickens as were described by the author in 1950 in sympathizing and sympathized human eyes, namely: torpid uveitis and papillitis, which dragged on for months, and affected not only the inoculated right eye, but also, after 3 weeks and more, the untouched left eye.
(19) Interactions among the important constituents of the fibrocartilage matrix cause meniscal tissue to behave as a fiber-reinforced, porous, permeable composite material similar to articular cartilage, in which frictional drag caused by fluid flow governs its response to dynamic loading.
(20) This enabled the section commander to drag away the fallen soldier, who was dazed but unharmed.