(n.) A nickname given to a person of Spanish (or, by extension, Portuguese or Italian) descent.
Example Sentences:
(1) Unlike thiorphan, 5 nmol RB38A alone was able to inhibit [3H]DAGO binding by 60%.
(2) SKF 38393 (1 microM)-stimulated adenylate cyclase activity was strongly reduced (by almost 60%) by the highly selective mu-agonist [D-Ala2, MePhe4, Gly-ol5]-enkephalin (DAGO; EC50 = 0.006 microM) and high concentrations of the selective delta-agonist [D-Ser2(O-tert-butyl), Leu5]-enkephalyl-Thr6 (DSTBU-LET; EC50 = 0.13 microM) but not by the selective delta-agonist [D-penicillamine2, D-penicillamine5]enkephalin (DPDPE).
(3) Centrally administered DADLE also attenuated baroreceptor reflexes, but was approximately 10- to 100-fold less potent than an equimolar amount of DAGO.
(4) 1, male Long-Evans rats were treated with unilateral microinjections of the mu agonist [D-Ala2-MePhe4, Gly-ol5]-enkephalin (DAGO), the delta agonist [D-Pen2, D-Pen5]-enkephalin (DPDPE) or the kappa agonist U50,488H, and the rate and duration of circling behaviour were measured.
(5) Heart rate, but not mean arterial blood pressure, increased in response to DAGO administration into the NTS while no significant cardiovascular changes were noted among the experimental groups in response to DAGO administered into the PVN.
(6) MOR, DAGO and NALO produced mixed effects (i.e., excitation or inhibition) on unit activity; however, the majority of cells examined (67%) were inhibited.
(7) This effect of DAGO was not due to spread to the third ventricle and subsequent diffusion via the CSF to another CNS site, since push-pull perfusion with this dose of DAGO in the region just dorsal to or in the posterior hypothalamus was ineffective in altering LH pulse amplitude.
(8) The mu-agonist DAGO ([D-Ala2,N-MePhe4,Gly-ol5]enkephalin; 0.75 nmol i.c.v.)
(9) Mu and delta receptors were labeled with the selective ligands 3H-DAGO (Tyr- D-Ala-Gly-MePhe-Gly-ol), and 3H-DPDPE (D-Pen2, D-Pen5-enkephalin), respectively, while the kappa receptors were labeled with 3H-(-)bremazocine in the presence of unlabeled DAGO and DPDPE.
(10) Morphine, Leu-enkephalin, D-Ala2, N-methyl-Phe4, Gly-ol5-enkephalin (DAGO) and D-Ser2-Leu-enkephalin-Thr (DSLET) each inhibited the synthesis of cyclic AMP.
(11) The purpose of the present study was firstly to determine whether morphine and (D-Ala2, NMe-Phe4, Gly-ol)-enkephalin (DAGO), a highly selective mu-agonist, increased intracellular free calcium of rat myocytes and secondly to determine whether opioid receptors were involved.
(12) We examined the interactions between glutamate and a selective mu opioid receptor agonist, D-Ala2-MePhe4-Gly-ol5-enkephalin (DAGO), in spinal trigeminal neurons in thin medullary slices of rats.
(13) mu-Receptors' agonist DAGO injection significantly decreased rat mortality in a posthemorrhagic period.
(14) In addition, naloxone antagonized the effect of DAGO.
(15) In non-deprived rats given a choice of water and 0.6% saline, ICV injections of DAGO (1 and 3 nmol) significantly increased the intake of 0.6% saline; baseline water intake was minimal and was unaffected by DAGO.
(16) Receptor autoradiographic studies with 3H-DAGO were carried out in the central gray to find receptor populations differing greatly in density between HAR and LAR mice to parallel their in vivo sensitivity differences: such receptors would then be implicated in mediating in vivo analgesia.
(17) Eighty percent of [3H]-[D-Ala2,D-Leu5] enkephalin (DADLE) binding was displaced by DAGO with high affinity, indicating that a high percentage of [3H]-DADLE binding was at mu-sites.
(18) In untreated animals, morphine and the mu-selective peptide, DAGO, induced relatively long-lasting dose-related decreases in responding, whereas the non-mu agonists, DPDPE and dynorphin, induced only transient effects: response rates increased at low doses and decreased at high doses.
(20) To examine the relative roles of mu 1- and mu 2-receptors in spinal and supraspinal analgesia, we assessed the effects of naloxonazine, naloxone, beta-funaltrexamine (beta-FNA), and ICI-154,129 on tail-flick analgesia produced by intrathecal or intracerebroventricular injections of the highly mu-selective agonist, [D-Ala2,Me-Phe4,Gly(ol)5]enkephalin (DAGO; mu 1 and mu 2), [D-Ser2,Leu5]enkephalin-Thr6 (DSLET; mu 1 and delta), and the selective delta-receptor agonist [D-Pen2,D-Pen5]enkephalin (DPDPE) in mice.
Descent
Definition:
(n.) The act of descending, or passing downward; change of place from higher to lower.
(n.) Incursion; sudden attack; especially, hostile invasion from sea; -- often followed by upon or on; as, to make a descent upon the enemy.
(n.) Progress downward, as in station, virtue, as in station, virtue, and the like, from a higher to a lower state, from a higher to a lower state, from the more to the less important, from the better to the worse, etc.
(n.) Derivation, as from an ancestor; procedure by generation; lineage; birth; extraction.
(n.) Transmission of an estate by inheritance, usually, but not necessarily, in the descending line; title to inherit an estate by reason of consanguinity.
(n.) Inclination downward; a descending way; inclined or sloping surface; declivity; slope; as, a steep descent.
(n.) That which is descended; descendants; issue.
(n.) A step or remove downward in any scale of gradation; a degree in the scale of genealogy; a generation.
(n.) Lowest place; extreme downward place.
(n.) A passing from a higher to a lower tone.
Example Sentences:
(1) These results suggest that the pelvic floor is affected by progressive denervation but descent during straining tends to decrease with advancing age.
(2) Blood samples were collected from an antecubital vein at sea level (S1), in a base camp at 1515 m prior to the summit ascent (S2), on the summit at 3285 m after 6.5 hours of climbing (S3), at base camp immediately after the descent (S4), and at sea level following a trail descent from the base camp (S5).
(3) A vaginal repair was not detectable radiologically and it did not correct a posterior descent.
(4) From the decreased alignment at the N-terminus and the presence of additional residues compared with bacterial phosphorylases, we conclude that the regulatory sequences that also carry the phosphorylation site in the muscle enzyme were joined to a presumed ancestral precursor gene by gene fusion after separation of the eukaryotic and prokaryotic lines of descent.
(5) It was determined that in the doses used, 4-MAPC failed to prevent testicular descent.
(6) With grievous amazement, never self-pitying but sometimes bordering on a sort of numbed wonderment, Levi records the day-to-day personal and social history of the camp, noting not only the fine gradations of his own descent, but the capacity of some prisoners to cut a deal and strike a bargain, while others, destined by their age or character for the gas ovens, follow "the slope down to the bottom, like streams that run down to the sea".
(7) The patients ranged in age from 15 to 69 years (mean, 37) and were predominantly male (14 patients) and white (only 1 was of oriental descent).
(8) Fifty-six (92%) of patients dying from pulmonary embolism were of African descent while 5 (8%) were of East Indian descent.
(9) It seems to adequately provide the additional needed lift when nipple descent has been no more than 1.5 to 2 cm below the inframammary crease.
(10) Using chi 2 analysis, we found that failure of external version was significantly associated with obesity, descent of the breech into the pelvis, decreased fluid, and fetal back positioned posteriorly.
(11) The open-sea dives were carried out with an average speed of descent of 3.95 feet per second and an average rate of ascent of 3.50 feet per second.
(12) Mortality levels of 100% for Culex quinquefasciatus and Musca domestica test insects were recorded under normal operating conditions during routine scheduled passenger flights with disinsection procedures undertaken at "blocks-away" or at "top-of-descent".
(13) Irwin said both Mohamed and CF were British citizens of Somali descent who had travelled to Somaliland – CF in 2009 and Mohamed in 2007.
(14) Through this technique, testicular descent can be observed in about 50% of male fetuses examined at weeks 28-30.
(15) Descent of a prosthesis below the desired inframammary crease is an infrequent but disturbing complication of augmentation mammaplasty, which may occur for a number of reasons.
(16) The percentage of women with the descent of uterus and vagina, uterus displacement and effort urine incontinence was found to increase with age, length of employment and number of deliveries, particularly high percentage being the one relating to women lifting, just once, heavy objects.
(17) Since the anterior colporrhaphy according to Stoeckel or Kelly is not capable of curing severe forms of stress incontinence with rotational descent of the urethra, our results show that an additional retropubic urethropoly is desirable and justified in these cases.
(18) The amyloid fibril protein seen in patients of Portuguese, Japanese, and Swedish descent in the U.S. mainly consists of a variant form of transthyretin (also called prealbumin) with the substitution of methionine for valine at position 30.
(19) This raises the possibility of two lines of descent from a common ancestor.
(20) The precise identities of the alleles are irrelevant to the linkage analysis so long as identity-by-descent and linkage-phase information are preserved.