(n.) A nickname given to a person of Spanish (or, by extension, Portuguese or Italian) descent.
Example Sentences:
(1) Unlike thiorphan, 5 nmol RB38A alone was able to inhibit [3H]DAGO binding by 60%.
(2) SKF 38393 (1 microM)-stimulated adenylate cyclase activity was strongly reduced (by almost 60%) by the highly selective mu-agonist [D-Ala2, MePhe4, Gly-ol5]-enkephalin (DAGO; EC50 = 0.006 microM) and high concentrations of the selective delta-agonist [D-Ser2(O-tert-butyl), Leu5]-enkephalyl-Thr6 (DSTBU-LET; EC50 = 0.13 microM) but not by the selective delta-agonist [D-penicillamine2, D-penicillamine5]enkephalin (DPDPE).
(3) Centrally administered DADLE also attenuated baroreceptor reflexes, but was approximately 10- to 100-fold less potent than an equimolar amount of DAGO.
(4) 1, male Long-Evans rats were treated with unilateral microinjections of the mu agonist [D-Ala2-MePhe4, Gly-ol5]-enkephalin (DAGO), the delta agonist [D-Pen2, D-Pen5]-enkephalin (DPDPE) or the kappa agonist U50,488H, and the rate and duration of circling behaviour were measured.
(5) Heart rate, but not mean arterial blood pressure, increased in response to DAGO administration into the NTS while no significant cardiovascular changes were noted among the experimental groups in response to DAGO administered into the PVN.
(6) MOR, DAGO and NALO produced mixed effects (i.e., excitation or inhibition) on unit activity; however, the majority of cells examined (67%) were inhibited.
(7) This effect of DAGO was not due to spread to the third ventricle and subsequent diffusion via the CSF to another CNS site, since push-pull perfusion with this dose of DAGO in the region just dorsal to or in the posterior hypothalamus was ineffective in altering LH pulse amplitude.
(8) The mu-agonist DAGO ([D-Ala2,N-MePhe4,Gly-ol5]enkephalin; 0.75 nmol i.c.v.)
(9) Mu and delta receptors were labeled with the selective ligands 3H-DAGO (Tyr- D-Ala-Gly-MePhe-Gly-ol), and 3H-DPDPE (D-Pen2, D-Pen5-enkephalin), respectively, while the kappa receptors were labeled with 3H-(-)bremazocine in the presence of unlabeled DAGO and DPDPE.
(10) Morphine, Leu-enkephalin, D-Ala2, N-methyl-Phe4, Gly-ol5-enkephalin (DAGO) and D-Ser2-Leu-enkephalin-Thr (DSLET) each inhibited the synthesis of cyclic AMP.
(11) The purpose of the present study was firstly to determine whether morphine and (D-Ala2, NMe-Phe4, Gly-ol)-enkephalin (DAGO), a highly selective mu-agonist, increased intracellular free calcium of rat myocytes and secondly to determine whether opioid receptors were involved.
(12) We examined the interactions between glutamate and a selective mu opioid receptor agonist, D-Ala2-MePhe4-Gly-ol5-enkephalin (DAGO), in spinal trigeminal neurons in thin medullary slices of rats.
(13) mu-Receptors' agonist DAGO injection significantly decreased rat mortality in a posthemorrhagic period.
(14) In addition, naloxone antagonized the effect of DAGO.
(15) In non-deprived rats given a choice of water and 0.6% saline, ICV injections of DAGO (1 and 3 nmol) significantly increased the intake of 0.6% saline; baseline water intake was minimal and was unaffected by DAGO.
(16) Receptor autoradiographic studies with 3H-DAGO were carried out in the central gray to find receptor populations differing greatly in density between HAR and LAR mice to parallel their in vivo sensitivity differences: such receptors would then be implicated in mediating in vivo analgesia.
(17) Eighty percent of [3H]-[D-Ala2,D-Leu5] enkephalin (DADLE) binding was displaced by DAGO with high affinity, indicating that a high percentage of [3H]-DADLE binding was at mu-sites.
(18) In untreated animals, morphine and the mu-selective peptide, DAGO, induced relatively long-lasting dose-related decreases in responding, whereas the non-mu agonists, DPDPE and dynorphin, induced only transient effects: response rates increased at low doses and decreased at high doses.
(20) To examine the relative roles of mu 1- and mu 2-receptors in spinal and supraspinal analgesia, we assessed the effects of naloxonazine, naloxone, beta-funaltrexamine (beta-FNA), and ICI-154,129 on tail-flick analgesia produced by intrathecal or intracerebroventricular injections of the highly mu-selective agonist, [D-Ala2,Me-Phe4,Gly(ol)5]enkephalin (DAGO; mu 1 and mu 2), [D-Ser2,Leu5]enkephalin-Thr6 (DSLET; mu 1 and delta), and the selective delta-receptor agonist [D-Pen2,D-Pen5]enkephalin (DPDPE) in mice.
Jack
Definition:
(n.) A large tree, the Artocarpus integrifolia, common in the East Indies, closely allied to the breadfruit, from which it differs in having its leaves entire. The fruit is of great size, weighing from thirty to forty pounds, and through its soft fibrous matter are scattered the seeds, which are roasted and eaten. The wood is of a yellow color, fine grain, and rather heavy, and is much used in cabinetwork. It is also used for dyeing a brilliant yellow.
(n.) A familiar nickname of, or substitute for, John.
(n.) An impertinent or silly fellow; a simpleton; a boor; a clown; also, a servant; a rustic.
(n.) A popular colloquial name for a sailor; -- called also Jack tar, and Jack afloat.
(n.) A mechanical contrivance, an auxiliary machine, or a subordinate part of a machine, rendering convenient service, and often supplying the place of a boy or attendant who was commonly called Jack
(n.) A device to pull off boots.
(n.) A sawhorse or sawbuck.
(n.) A machine or contrivance for turning a spit; a smoke jack, or kitchen jack.
(n.) A wooden wedge for separating rocks rent by blasting.
(n.) A lever for depressing the sinkers which push the loops down on the needles.
(n.) A grating to separate and guide the threads; a heck box.
(n.) A machine for twisting the sliver as it leaves the carding machine.
(n.) A compact, portable machine for planing metal.
(n.) A machine for slicking or pebbling leather.
(n.) A system of gearing driven by a horse power, for multiplying speed.
(n.) A hood or other device placed over a chimney or vent pipe, to prevent a back draught.
(n.) In the harpsichord, an intermediate piece communicating the action of the key to the quill; -- called also hopper.
(n.) In hunting, the pan or frame holding the fuel of the torch used to attract game at night; also, the light itself.
(n.) A portable machine variously constructed, for exerting great pressure, or lifting or moving a heavy body through a small distance. It consists of a lever, screw, rack and pinion, hydraulic press, or any simple combination of mechanical powers, working in a compact pedestal or support and operated by a lever, crank, capstan bar, etc. The name is often given to a jackscrew, which is a kind of jack.
(n.) The small bowl used as a mark in the game of bowls.
(n.) The male of certain animals, as of the ass.
(n.) A young pike; a pickerel.
(n.) The jurel.
(n.) A large, California rock fish (Sebastodes paucispinus); -- called also boccaccio, and merou.
(n.) The wall-eyed pike.
(n.) A drinking measure holding half a pint; also, one holding a quarter of a pint.
(n.) A flag, containing only the union, without the fly, usually hoisted on a jack staff at the bowsprit cap; -- called also union jack. The American jack is a small blue flag, with a star for each State.
(n.) A bar of iron athwart ships at a topgallant masthead, to support a royal mast, and give spread to the royal shrouds; -- called also jack crosstree.
(n.) The knave of a suit of playing cards.
(n.) A coarse and cheap mediaeval coat of defense, esp. one made of leather.
(n.) A pitcher or can of waxed leather; -- called also black jack.
(v. i.) To hunt game at night by means of a jack. See 2d Jack, n., 4, n.
(v. t.) To move or lift, as a house, by means of a jack or jacks. See 2d Jack, n., 5.
Example Sentences:
(1) A remarkably close relationship was found between both H. pylori urease subunits and jack bean (Canavalia ensiformis) urease, the subunit of which is a single 840 amino acid polypeptide.
(2) In 0.17 M Na+(aq), tRNA(Phe) exists in its native conformation and the number of strong binding sites (Ka greater than or equal to 10(4)) was estimated to be 3-4 by titration experiments, in agreement with X-ray structural data for crystalline tRNA(Phe) (Jack et al., 1977).
(3) Jack Straw, foreign secretary at the time of the Iraq war, took a less dramatic view.
(4) precursor phaseolin) is incubated with jack bean alpha-mannosidase show that the high mannose glycan on Asn252, but not the one on Asn341, is susceptible to enzyme degradation.
(5) "My wonderful, brave and adored father, Jack Ashley, Lord Ashley of Stoke, has died after a short battle with pneumonia."
(6) 9.31am BST Jack Straw , the Labour former home secretary, was on the Today programme earlier talking about the "plebgate" affair.
(7) This communication reviews the almost 40 years of studies by Jack Metcoff, MD, and coworkers to unravel the causes of fetal malnutrition and their efforts to prevent it.
(8) "Most of the grain produced on our farm ends up bound for export," said Jack McCormick, who raises beef cattle and grain with his father.
(9) Jack Straw's detailed blueprint for a 300- strong, wholly elected upper chamber to replace the Lords appears to have been blocked at the last minute following resistance in cabinet.
(10) His opposite number, Roy Carroll, saved at the feet of Sinclair, the County striker Izale McLeod drove inches wide, but in the 24th minute Villa were level, Jack Grealish dancing through a series of attempted tackles before putting the ball on a plate inside the penalty area for the hugely promising Adama Traoré to thump past Carroll.
(11) The manager added that City would also be without Kolo Touré, Abdul Razak and Jack Rodwell, who has a hamstring problem.
(12) Comment is free contributor Jack Monroe made the Guardian shortlist and got one commenter's You Tell Us award for Outstanding Excellence in the field of Talking Sense .
(13) The link between the conditions has not yet been discovered, but here Jack Wall and colleagues develop the theory that an autoimmune response to a 64 kDa antigen expressed on both thyroid and eye muscle membranes is responsible for this thyroid-associated ophthalmopathy.
(14) Fellow co-founder Jack Dorsey could make around half that.
(15) Other high-profile absentees include Danny Welbeck, Jack Wilshere, Luke Shaw and Jordan Henderson.
(16) Onerous new regulations could threaten the shale energy revolution, America’s role as a global energy superpower, and the dramatic reductions in CO2 emissions made possible by an abundant and affordable domestic supply of clean-burning natural gas,” Jack Gerrard, president of the American Petroleum Institute, said in a statement.
(17) The American has not secured a major title since Torrey Pines for the 2008 US Open and, while overhauling Jack Nicklaus's record total of 18 majors was once a matter of "when", it is now very much a case of "if".
(18) By N-terminal analysis, the 29.5-kDa subunit of H. pylori urease was found to share significant amino acid sequence similarity with the smallest of three subunits of the Proteus mirabilis and Morganella morganii ureases, as well as to the amino terminus of the unique jack bean subunit.
(19) Outside-funded overseas travel was also declared, including a visit to the Paris Air show for the Tory MP Jack Lopresti and his researcher, paid for by the global missile company MBDA.
(20) Even Jack Straw is trying to close down some of its overripe practices.