(n.) A nickname given to a person of Spanish (or, by extension, Portuguese or Italian) descent.
Example Sentences:
(1) Unlike thiorphan, 5 nmol RB38A alone was able to inhibit [3H]DAGO binding by 60%.
(2) SKF 38393 (1 microM)-stimulated adenylate cyclase activity was strongly reduced (by almost 60%) by the highly selective mu-agonist [D-Ala2, MePhe4, Gly-ol5]-enkephalin (DAGO; EC50 = 0.006 microM) and high concentrations of the selective delta-agonist [D-Ser2(O-tert-butyl), Leu5]-enkephalyl-Thr6 (DSTBU-LET; EC50 = 0.13 microM) but not by the selective delta-agonist [D-penicillamine2, D-penicillamine5]enkephalin (DPDPE).
(3) Centrally administered DADLE also attenuated baroreceptor reflexes, but was approximately 10- to 100-fold less potent than an equimolar amount of DAGO.
(4) 1, male Long-Evans rats were treated with unilateral microinjections of the mu agonist [D-Ala2-MePhe4, Gly-ol5]-enkephalin (DAGO), the delta agonist [D-Pen2, D-Pen5]-enkephalin (DPDPE) or the kappa agonist U50,488H, and the rate and duration of circling behaviour were measured.
(5) Heart rate, but not mean arterial blood pressure, increased in response to DAGO administration into the NTS while no significant cardiovascular changes were noted among the experimental groups in response to DAGO administered into the PVN.
(6) MOR, DAGO and NALO produced mixed effects (i.e., excitation or inhibition) on unit activity; however, the majority of cells examined (67%) were inhibited.
(7) This effect of DAGO was not due to spread to the third ventricle and subsequent diffusion via the CSF to another CNS site, since push-pull perfusion with this dose of DAGO in the region just dorsal to or in the posterior hypothalamus was ineffective in altering LH pulse amplitude.
(8) The mu-agonist DAGO ([D-Ala2,N-MePhe4,Gly-ol5]enkephalin; 0.75 nmol i.c.v.)
(9) Mu and delta receptors were labeled with the selective ligands 3H-DAGO (Tyr- D-Ala-Gly-MePhe-Gly-ol), and 3H-DPDPE (D-Pen2, D-Pen5-enkephalin), respectively, while the kappa receptors were labeled with 3H-(-)bremazocine in the presence of unlabeled DAGO and DPDPE.
(10) Morphine, Leu-enkephalin, D-Ala2, N-methyl-Phe4, Gly-ol5-enkephalin (DAGO) and D-Ser2-Leu-enkephalin-Thr (DSLET) each inhibited the synthesis of cyclic AMP.
(11) The purpose of the present study was firstly to determine whether morphine and (D-Ala2, NMe-Phe4, Gly-ol)-enkephalin (DAGO), a highly selective mu-agonist, increased intracellular free calcium of rat myocytes and secondly to determine whether opioid receptors were involved.
(12) We examined the interactions between glutamate and a selective mu opioid receptor agonist, D-Ala2-MePhe4-Gly-ol5-enkephalin (DAGO), in spinal trigeminal neurons in thin medullary slices of rats.
(13) mu-Receptors' agonist DAGO injection significantly decreased rat mortality in a posthemorrhagic period.
(14) In addition, naloxone antagonized the effect of DAGO.
(15) In non-deprived rats given a choice of water and 0.6% saline, ICV injections of DAGO (1 and 3 nmol) significantly increased the intake of 0.6% saline; baseline water intake was minimal and was unaffected by DAGO.
(16) Receptor autoradiographic studies with 3H-DAGO were carried out in the central gray to find receptor populations differing greatly in density between HAR and LAR mice to parallel their in vivo sensitivity differences: such receptors would then be implicated in mediating in vivo analgesia.
(17) Eighty percent of [3H]-[D-Ala2,D-Leu5] enkephalin (DADLE) binding was displaced by DAGO with high affinity, indicating that a high percentage of [3H]-DADLE binding was at mu-sites.
(18) In untreated animals, morphine and the mu-selective peptide, DAGO, induced relatively long-lasting dose-related decreases in responding, whereas the non-mu agonists, DPDPE and dynorphin, induced only transient effects: response rates increased at low doses and decreased at high doses.
(20) To examine the relative roles of mu 1- and mu 2-receptors in spinal and supraspinal analgesia, we assessed the effects of naloxonazine, naloxone, beta-funaltrexamine (beta-FNA), and ICI-154,129 on tail-flick analgesia produced by intrathecal or intracerebroventricular injections of the highly mu-selective agonist, [D-Ala2,Me-Phe4,Gly(ol)5]enkephalin (DAGO; mu 1 and mu 2), [D-Ser2,Leu5]enkephalin-Thr6 (DSLET; mu 1 and delta), and the selective delta-receptor agonist [D-Pen2,D-Pen5]enkephalin (DPDPE) in mice.
Mediterranean
Definition:
(a.) Inclosed, or nearly inclosed, with land; as, the Mediterranean Sea, between Europe and Africa.
(a.) Inland; remote from the ocean.
(a.) Of or pertaining to the Mediterranean Sea; as, Mediterranean trade; a Mediterranean voyage.
Example Sentences:
(1) Six marine bacteria which synthesize macromolecular antibiotics were isolated from neritic waters on the French Mediterranean coast, and their frequency recorded over two successive years.
(2) The authors report a resurgence of this disease during the last years, with a 5 human cases per 100,000 annual prevalence and a 6 per cent of rate death, the most active part of mediterranean area appears to be the region of Grand-Kabylie.
(3) It is now recognized that dwarfism in males is frequent around the Mediterranean, where wheat is the staple of life and has been grown for 4,000 years on the same soil, thereby resulting in the depletion of zinc.
(4) Among possible causes for the increase in deaths in the Mediterranean this year, the agency cited a worsening quality of vessels and smugglers’ tactics to avoid detection by authorities, such as sending many boats out at the same time, which makes the work of rescuers harder.
(5) The functional and phyletic significance of this material reveals a complex pattern of behavioral and phyletic diversity among large-bodied catarrhines in Europe and suggests that this diversity evolved in situ from circum-Mediterranean middle Miocene ancestors.
(6) Mediterranean countries, parts of southern Africa and South America would experience 20% to 30% less water availability.
(7) This condition is a genodermatosis, seen chiefly around the shores of the Mediterranean, characterised by early pigment disturbances which progress virtually inexorably towards a diffuse epitheliomatosis which usually results in death before the age of 20 years.
(8) A variety of sources can account for marine pollution by genotoxic, carcinogenic, and teratogenic compounds, but there is a relative paucity of analytical data concerning the Mediterranean.
(9) Vigils have been held in Cairo for the victims of EgyptAir flight 804 as a French navy ship headed to join the deep-sea search in the Mediterranean for the main wreckage and flight recorders.
(10) Novel structural changes in members of the serum amyloid A (SAA) gene family have been found in four patients of varied ethnic backgrounds with familial Mediterranean fever.
(11) Up to 100 children may have died in the weekend’s catastrophic shipwreck in the Mediterranean, a relief agency has said as prosecutors in Sicily arrested the alleged commander of the wooden fishing vessel and a member of his crew.
(12) This was equivalent to nearly nearly half the number rescued last May, a month which saw an unprecedented level of migration in the Mediterranean.
(13) Cases of cystic echinococcosis (E. granulosus) diagnosed in Central Europe are often imported from mediterranean countries.
(14) Anything that good for you might be expected to smell foul and come in a medicine bottle, but the Mediterranean diet is generally considered to be delicious, except by those who hate olive oil.
(15) Michelangelo Merisi da Caravaggio (1571-1610) died young, had a public career for only 10 years, had no workshop, bequeathed no drawings and left no pupils, and the only places he travelled to outside mainland Italy were the Mediterranean speck of Malta and, briefly, Sicily.
(16) About one-third of our postmastectomy patients are corpulent, middle-aged women with "Mediterranean" body structures.
(17) The northern Mediterranean has been Europe's soft underbelly during the crisis.
(18) They belonged to two ethnic groups--Mediterranean and Asian--and 53% were under the age of 6 years, the oldest being 20 years.
(19) Mediterranean patients (N = 16) had features intermediary between the two other groups.
(20) A C----T mutation at nucleotide 563 of G6PD Mediterranean has been identified by Vulliamy et al., and the same mutation has been found by De Vita et al.