(n.) A nickname given to a person of Spanish (or, by extension, Portuguese or Italian) descent.
Example Sentences:
(1) Unlike thiorphan, 5 nmol RB38A alone was able to inhibit [3H]DAGO binding by 60%.
(2) SKF 38393 (1 microM)-stimulated adenylate cyclase activity was strongly reduced (by almost 60%) by the highly selective mu-agonist [D-Ala2, MePhe4, Gly-ol5]-enkephalin (DAGO; EC50 = 0.006 microM) and high concentrations of the selective delta-agonist [D-Ser2(O-tert-butyl), Leu5]-enkephalyl-Thr6 (DSTBU-LET; EC50 = 0.13 microM) but not by the selective delta-agonist [D-penicillamine2, D-penicillamine5]enkephalin (DPDPE).
(3) Centrally administered DADLE also attenuated baroreceptor reflexes, but was approximately 10- to 100-fold less potent than an equimolar amount of DAGO.
(4) 1, male Long-Evans rats were treated with unilateral microinjections of the mu agonist [D-Ala2-MePhe4, Gly-ol5]-enkephalin (DAGO), the delta agonist [D-Pen2, D-Pen5]-enkephalin (DPDPE) or the kappa agonist U50,488H, and the rate and duration of circling behaviour were measured.
(5) Heart rate, but not mean arterial blood pressure, increased in response to DAGO administration into the NTS while no significant cardiovascular changes were noted among the experimental groups in response to DAGO administered into the PVN.
(6) MOR, DAGO and NALO produced mixed effects (i.e., excitation or inhibition) on unit activity; however, the majority of cells examined (67%) were inhibited.
(7) This effect of DAGO was not due to spread to the third ventricle and subsequent diffusion via the CSF to another CNS site, since push-pull perfusion with this dose of DAGO in the region just dorsal to or in the posterior hypothalamus was ineffective in altering LH pulse amplitude.
(8) The mu-agonist DAGO ([D-Ala2,N-MePhe4,Gly-ol5]enkephalin; 0.75 nmol i.c.v.)
(9) Mu and delta receptors were labeled with the selective ligands 3H-DAGO (Tyr- D-Ala-Gly-MePhe-Gly-ol), and 3H-DPDPE (D-Pen2, D-Pen5-enkephalin), respectively, while the kappa receptors were labeled with 3H-(-)bremazocine in the presence of unlabeled DAGO and DPDPE.
(10) Morphine, Leu-enkephalin, D-Ala2, N-methyl-Phe4, Gly-ol5-enkephalin (DAGO) and D-Ser2-Leu-enkephalin-Thr (DSLET) each inhibited the synthesis of cyclic AMP.
(11) The purpose of the present study was firstly to determine whether morphine and (D-Ala2, NMe-Phe4, Gly-ol)-enkephalin (DAGO), a highly selective mu-agonist, increased intracellular free calcium of rat myocytes and secondly to determine whether opioid receptors were involved.
(12) We examined the interactions between glutamate and a selective mu opioid receptor agonist, D-Ala2-MePhe4-Gly-ol5-enkephalin (DAGO), in spinal trigeminal neurons in thin medullary slices of rats.
(13) mu-Receptors' agonist DAGO injection significantly decreased rat mortality in a posthemorrhagic period.
(14) In addition, naloxone antagonized the effect of DAGO.
(15) In non-deprived rats given a choice of water and 0.6% saline, ICV injections of DAGO (1 and 3 nmol) significantly increased the intake of 0.6% saline; baseline water intake was minimal and was unaffected by DAGO.
(16) Receptor autoradiographic studies with 3H-DAGO were carried out in the central gray to find receptor populations differing greatly in density between HAR and LAR mice to parallel their in vivo sensitivity differences: such receptors would then be implicated in mediating in vivo analgesia.
(17) Eighty percent of [3H]-[D-Ala2,D-Leu5] enkephalin (DADLE) binding was displaced by DAGO with high affinity, indicating that a high percentage of [3H]-DADLE binding was at mu-sites.
(18) In untreated animals, morphine and the mu-selective peptide, DAGO, induced relatively long-lasting dose-related decreases in responding, whereas the non-mu agonists, DPDPE and dynorphin, induced only transient effects: response rates increased at low doses and decreased at high doses.
(20) To examine the relative roles of mu 1- and mu 2-receptors in spinal and supraspinal analgesia, we assessed the effects of naloxonazine, naloxone, beta-funaltrexamine (beta-FNA), and ICI-154,129 on tail-flick analgesia produced by intrathecal or intracerebroventricular injections of the highly mu-selective agonist, [D-Ala2,Me-Phe4,Gly(ol)5]enkephalin (DAGO; mu 1 and mu 2), [D-Ser2,Leu5]enkephalin-Thr6 (DSLET; mu 1 and delta), and the selective delta-receptor agonist [D-Pen2,D-Pen5]enkephalin (DPDPE) in mice.
Pejorative
Definition:
(a.) Implying or imputing evil; depreciatory; disparaging; unfavorable.
Example Sentences:
(1) The concept of "polypharmacy", a pejorative and meaningless term, nevertheless gave rise to useful surveys on combined drug use, to methods of monitoring and controlling multiple drug use, and to a small number of studies which imply that a few psychoactive drug-drug combinations are rational.
(2) The radiological analysis of femoro-tibial compartments in comparison with the non operative side showed a clear pejorative difference in one case, moderate in 5 without incriminating the morphological type.
(3) That is a pejorative accusation, that’s not the phrase that I would use to describe what I read about this week,” Kaine said.
(4) At the beginning, David Cameron spoke respectfully of "President Mubarak" and the "Egyptian government"; by this weekend, the prime minister is using the much more pejorative "regime" to describe the crumbling autocracy.
(5) Sudden, unpredictable mood swings are common and there is a greater tendency for their physicians to diagnose personality disorders, often in pejorative terms.
(6) Three factors were found to be statistically significant: adjuvant hormonotherapy, loco-regional metastases, adjuvant adriamycin containing regimen (pejorative prognostic factor).
(7) He also memorably attacked Obama for investing $90bn on "green energy" – a phrase delivered as a pejorative.
(8) Lymph node involvement appeared to be the most pejorative factor (p < or = 10(-5)).
(9) He said the Daily Mail and the Mail on Sunday had also signed up to the editors' code of practice, which states that pejorative references to someone's sexuality must be avoided.
(10) Steven Hughes says that Talking Man is Steve Wilson: "And I wish he'd stop Lawrenson using 'sad', as a pejorative term, when 'Lawro' talks about all the ephemera that surrounds football - like statistics and such.
(11) (You need to know that "dog" is pejorative slang in America for an ill-favoured woman).
(12) A multifactorial analysis enabled us to quantify the pejorative impact on fertility of each of the factors which significantly affect the fertility results.
(13) Jeremy Clarkson , put on final warning by the BBC earlier this year, deliberately used a pejorative racial term to refer to an Asian man on BBC2’s Top Gear, causing offence without justification and breaching broadcasting rules.
(14) As far as irreducible tinnitus are concerned, as anxiety is the most pejorative parameter, not discouraging the patient is very important.
(15) The description of east Jerusalem as ‘occupied east Jerusalem’ is a term freighted with pejorative implications, which is neither appropriate nor useful,” Brandis told the Senate estimates hearing.
(16) Society's negative and pejorative attitude toward the disabled is discussed to explain the psychological trauma associated with any first or second disability.
(17) Lebanese band the Great Departed use oudh music and untranslatable cultural references to target Isis – “Daesh” in the pejorative Arabic term – to side-splitting laughter in Beirut nightclubs.
(18) "However, the court did not appreciate that when national newspapers make repeated irrelevant references to my sexuality – particularly in the context of pejorative and stereotypical reference to appearance – it amounts to the same kind of mocking which the court has confirmed is unacceptable.
(19) According to pastor Joy, among themselves party members often use the pejorative expression yang jiao to designate Christianity.
(20) It makes the point that the term "hung parliament" is pejorative, even though many would argue that there is a lot to be said for no one party having an overall majority.