(n.) A nickname given to a person of Spanish (or, by extension, Portuguese or Italian) descent.
Example Sentences:
(1) Unlike thiorphan, 5 nmol RB38A alone was able to inhibit [3H]DAGO binding by 60%.
(2) SKF 38393 (1 microM)-stimulated adenylate cyclase activity was strongly reduced (by almost 60%) by the highly selective mu-agonist [D-Ala2, MePhe4, Gly-ol5]-enkephalin (DAGO; EC50 = 0.006 microM) and high concentrations of the selective delta-agonist [D-Ser2(O-tert-butyl), Leu5]-enkephalyl-Thr6 (DSTBU-LET; EC50 = 0.13 microM) but not by the selective delta-agonist [D-penicillamine2, D-penicillamine5]enkephalin (DPDPE).
(3) Centrally administered DADLE also attenuated baroreceptor reflexes, but was approximately 10- to 100-fold less potent than an equimolar amount of DAGO.
(4) 1, male Long-Evans rats were treated with unilateral microinjections of the mu agonist [D-Ala2-MePhe4, Gly-ol5]-enkephalin (DAGO), the delta agonist [D-Pen2, D-Pen5]-enkephalin (DPDPE) or the kappa agonist U50,488H, and the rate and duration of circling behaviour were measured.
(5) Heart rate, but not mean arterial blood pressure, increased in response to DAGO administration into the NTS while no significant cardiovascular changes were noted among the experimental groups in response to DAGO administered into the PVN.
(6) MOR, DAGO and NALO produced mixed effects (i.e., excitation or inhibition) on unit activity; however, the majority of cells examined (67%) were inhibited.
(7) This effect of DAGO was not due to spread to the third ventricle and subsequent diffusion via the CSF to another CNS site, since push-pull perfusion with this dose of DAGO in the region just dorsal to or in the posterior hypothalamus was ineffective in altering LH pulse amplitude.
(8) The mu-agonist DAGO ([D-Ala2,N-MePhe4,Gly-ol5]enkephalin; 0.75 nmol i.c.v.)
(9) Mu and delta receptors were labeled with the selective ligands 3H-DAGO (Tyr- D-Ala-Gly-MePhe-Gly-ol), and 3H-DPDPE (D-Pen2, D-Pen5-enkephalin), respectively, while the kappa receptors were labeled with 3H-(-)bremazocine in the presence of unlabeled DAGO and DPDPE.
(10) Morphine, Leu-enkephalin, D-Ala2, N-methyl-Phe4, Gly-ol5-enkephalin (DAGO) and D-Ser2-Leu-enkephalin-Thr (DSLET) each inhibited the synthesis of cyclic AMP.
(11) The purpose of the present study was firstly to determine whether morphine and (D-Ala2, NMe-Phe4, Gly-ol)-enkephalin (DAGO), a highly selective mu-agonist, increased intracellular free calcium of rat myocytes and secondly to determine whether opioid receptors were involved.
(12) We examined the interactions between glutamate and a selective mu opioid receptor agonist, D-Ala2-MePhe4-Gly-ol5-enkephalin (DAGO), in spinal trigeminal neurons in thin medullary slices of rats.
(13) mu-Receptors' agonist DAGO injection significantly decreased rat mortality in a posthemorrhagic period.
(14) In addition, naloxone antagonized the effect of DAGO.
(15) In non-deprived rats given a choice of water and 0.6% saline, ICV injections of DAGO (1 and 3 nmol) significantly increased the intake of 0.6% saline; baseline water intake was minimal and was unaffected by DAGO.
(16) Receptor autoradiographic studies with 3H-DAGO were carried out in the central gray to find receptor populations differing greatly in density between HAR and LAR mice to parallel their in vivo sensitivity differences: such receptors would then be implicated in mediating in vivo analgesia.
(17) Eighty percent of [3H]-[D-Ala2,D-Leu5] enkephalin (DADLE) binding was displaced by DAGO with high affinity, indicating that a high percentage of [3H]-DADLE binding was at mu-sites.
(18) In untreated animals, morphine and the mu-selective peptide, DAGO, induced relatively long-lasting dose-related decreases in responding, whereas the non-mu agonists, DPDPE and dynorphin, induced only transient effects: response rates increased at low doses and decreased at high doses.
(20) To examine the relative roles of mu 1- and mu 2-receptors in spinal and supraspinal analgesia, we assessed the effects of naloxonazine, naloxone, beta-funaltrexamine (beta-FNA), and ICI-154,129 on tail-flick analgesia produced by intrathecal or intracerebroventricular injections of the highly mu-selective agonist, [D-Ala2,Me-Phe4,Gly(ol)5]enkephalin (DAGO; mu 1 and mu 2), [D-Ser2,Leu5]enkephalin-Thr6 (DSLET; mu 1 and delta), and the selective delta-receptor agonist [D-Pen2,D-Pen5]enkephalin (DPDPE) in mice.
Sense
Definition:
(v. t.) A faculty, possessed by animals, of perceiving external objects by means of impressions made upon certain organs (sensory or sense organs) of the body, or of perceiving changes in the condition of the body; as, the senses of sight, smell, hearing, taste, and touch. See Muscular sense, under Muscular, and Temperature sense, under Temperature.
(v. t.) Perception by the sensory organs of the body; sensation; sensibility; feeling.
(v. t.) Perception through the intellect; apprehension; recognition; understanding; discernment; appreciation.
(v. t.) Sound perception and reasoning; correct judgment; good mental capacity; understanding; also, that which is sound, true, or reasonable; rational meaning.
(v. t.) That which is felt or is held as a sentiment, view, or opinion; judgment; notion; opinion.
(v. t.) Meaning; import; signification; as, the true sense of words or phrases; the sense of a remark.
(v. t.) Moral perception or appreciation.
(v. t.) One of two opposite directions in which a line, surface, or volume, may be supposed to be described by the motion of a point, line, or surface.
(v. t.) To perceive by the senses; to recognize.
Example Sentences:
(1) An “out” vote would severely disrupt our lives, in an economic sense and a private sense.
(2) But it will be a subtle difference, because it's already abundantly clear there's no danger of the war being suddenly forgotten, or made to seem irrelevant to our sense of what Europe and the world has to avoid repeating.
(3) One would expect banks to interpret this in a common sense and straightforward way without trying to circumvent it."
(4) Yesterday's flight may not quite have been one small step for man, but the hyperbole and the sense of history weighed heavily on those involved.
(5) Since the molecular weight of IgG is more than twice that of albumin and transferrin, it is concluded that the protein loss in Ménétrier's disease is nonselective in the sense that it affects a similar fraction of the intravascular masses of all plasma proteins.
(6) In this sense, there is evidence that in genetically susceptible individuals, environmental stresses can influence the long-term level of arterial pressure via the central and peripheral neural autonomic pathways.
(7) He captivated me, but not just because of his intellect; it was for his wisdom, his psychological insights and his sense of humour that I will always remember our dinners together.
(8) The narX gene product may be involved in sensing nitrate and phosphorylating NARL.
(9) The second reason it makes sense for Osborne not to crow too much is that in terms of output per head of population, the downturn is still not over.
(10) Longer times of radiolabeling demonstrated that the nascent RNA accumulated as 42S RNA, which was primarily of the same sense as the virion strand when it was radiolabeled at 5 h postinfection.
(11) Autonomy, sense of accomplishment and time spent in patient care ranked as the top three factors contributing to job satisfaction.
(12) Whether out of fear, indifference or a sense of impotence, the general population has learned to turn away, like commuters speeding by on the freeways to the suburbs, unseeingly passing over the squalor.
(13) The anticoagulant therapy undertaken by the patient appears to be of some benefit in the sense that no recurrence of thrombotic manifestations occurred.
(14) The results showed that measles virus produced three size classes of plus-sense N-containing RNA species corresponding to monocistronic N RNA, bicistronic NP RNA, and antigenomes.
(15) In this sense synapse formation must be considered a drawn out affair.
(16) The last time Republic of Ireland played here in Dublin they produced a performance and result to stir the senses.
(17) The problem is that too many people in this place just get advised by people who are just like them, so there’s groupthink, and they have no sense of what it’s like out there.” Is he talking about his predecessor?
(18) Stimulation threshold, sensing, and resistance measurements from both leads were comparable.
(19) We just hope that … maybe she’s gone to see her friend, talk some sense into her,” Renu said, adding that Shamima “knew that it was a silly thing to do” and that she did not know why her friend had done it.
(20) A doctor the Guardian later speaks to insists it makes no sense.