(1) Seminiferous epithelium in adult rats was studied by light and electron microscopy after 5 weeks of chronic administration of GnRH antagonist (Ac-D2 Nal 1, D4ClPhe 2, DTrp 3, DArg 6, DAla 10; GnRH code-103-289-10, National Institutes of Health, USA).
(2) The pattern of divergent transcription of the argEC BH cluster of genes previously demonstrated by the hybridization of RNA to the separated strand of a phi 80 darg transducing phage, is confirmed with the DNA of a set of different lambdadarg phages.
(3) In semi-thin preparations of rat testis treated with GnRH antagonist (Ac-D2Nal 1, D4ClPhe 2, DTrp 3, DArg 6, DAla 10; GnRH code- 103-289-10, National Institutes of Health, USA) for a period of 5 weeks, Leydig cells showed a reduction of 18% in the mean nuclear area as compared to the controls.
(4) Six adult ovariectomized rhesus macaques were given a gonadotropin-releasing hormone (GnRH) antagonist [Ac-beta-(2)DNAL,pFDPhe,DTrp,DArg]-GnRH, by intravenous infusion for 3 to 3.5 days to determine whether the positive feedback action of estradiol benzoate (E2B) on pituitary luteinizing hormone (LH) secretion could be inhibited by blockage of GnRH binding to pituitary gonadotropes.
(5) NPC 567 (DArg[Hyp3,DPhe7]-bradykinin), a B2 receptor antagonist, had no effect on bradykinin-induced 45Ca2+ efflux, but abolished prostaglandin synthesis.
(6) Both collagenases split bonds Gln-Gly and Leu-Gly in synthetic peptides DNP-Pro-Gln-Gly-Ile-Ala-Gly-Gln-DArg-OH and DNP-Pro-Leu-Gly-Ile-Ala-Gly-DArg-NH2, respectively.
(7) The effect of bradykinin was suppressed by the competitive kinin antagonist [DArg,Hyp3,Thi5,8,DPhe7]bradykinin.
(8) To examine the role of intrarenal kinins in deoxycorticosterone acetate-salt-treated rats, which have high renal kallikrein, Fab fragments of antibradykinin antibody or DArg[Hyp3Thi5,8DPhe7]bradykinin, a kinin antagonist, were used to block kinins.
(9) DArg[Hyp3,Gly6,Leu8]BK showed high affinity on Rb.J.V.
(10) Two new B1 receptor antagonists, [Hyp3,Thi5,DTic7,Oic8]desArg9-BK and DArg[Hyp3,Thi5,DTic7,Oic8]desArg9-BK were tested in vitro on the rabbit jugular vein and the guinea pig ileum (preparations containing B2 receptors) and on the rabbit aorta (preparation containing B1 receptors) for pharmacological characterization.
(11) In an amidolytic assay, the Ki values for the inhibition of human urinary kallikrein were 0.5, 0.3, and 2.5 microM for B4307 (DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DPhe-Thi-Arg), B4308 (Lys-Lys-Arg-Hyp-Hyp-Gly-Thi-Ser-DPhe-Thi-Arg) and B3852 (Arg-Pro-Hyp-Gly-Phe-Ser-DPhe-Phe-Arg), respectively.
(12) Heteroduplex DNA mapping of these lumbdadarg and of the phi 80 darg isolated by B. Konrad indicates that the two kinds of phages carry the arg cluster in opposite orientations, a situation favorable for the isolation of argECBH DNA.
(13) DArg[Hyp3,DPhe7,Leu8]-BK showed pA2 values of 8.86 on Rb.J.V., but only 6.77 on G.P.I.
(14) In this study, we have used the potent, specific bradykinin antagonist DArg[Hyp3DPhe7] bradykinin (NPC 567) as a probe to examine the role of bradykinin in carrageenan-induced edema in the paws of rats.
(15) In a second group of rats pretreated with a B2 kinin receptor antagonist, [DArg Hyp3, Thi5,8 D Phe7]bradykinin, AA infusion raised urinary kinins identically as in untreated controls, but GFR and RPF responses were absent.
(16) [Arg1(Tos),Hyp3,Thi5,DTic7,Oic8]-BK and DArg[Hyp3,Thi5,DTic7,Oic8]-BK showed almost similar pA2 values on both Rb.J.V.
(17) The length (in kilobases, kb) of the segments, determined by electron microscopy and ararose gel electrophoresis is 4.2, 7.5, 8.4, 6.2, 6.9, and 6.4 kb for gamma darg13; 13.0, 7.5, 4.7, 6.2, 6.9, and 6.4 kb for gamma darg 14: and 5.3, 11.0, 4.7, 6.2, 6.9, and 6.4 kb for gamma darg23.
(18) The Ki values for B4307 (DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DPhe-Thi-Arg), B4308 (Lys-Lys-Arg-Hyp-Hyp-Gly-Thi-Ser-DPhe-Thi-Arg), and B3852 (Arg-Pro-Hyp-Gly-Phe-Ser-DPhe-Phe-Arg) are 0.5, 0.3 and 2.5 microM, respectively.
(19) Two novel analogs of bradykinin (BK), [DAla7]-BK and DArg-BK, exhibited a dissociation of smooth muscle activities toward higher potency on the uterus than on the ileum, in spite of increased metabolic stability to pulmonary enzymatic breakdown in the rat blood pressure assay.
(20) The bradykinin analogs [desArg9,Leu8]BK and DArg[Hyp3,DPhe7]BK have been reported to have antagonist activity at the B1 and B2 bradykinin receptors in smooth muscle, respectively.
Darn
Definition:
(v. t.) To mend as a rent or hole, with interlacing stitches of yarn or thread by means of a needle; to sew together with yarn or thread.
(n.) A place mended by darning.
(v. t.) A colloquial euphemism for Damn.
Example Sentences:
(1) But this is how we live even before we are forced, through penury to claim: fine dining on stewed leftovers, nursing our one drink on those rare social events, cutting our own hair, patchwork-darned clothes and leaky shoes.
(2) To non-artists, there may not seem to be anything original or provocative about love, death, loneliness or cheese, either – yet gosh-darned artists keep finding new ways for humanity to look at them.
(3) There were a similar number of sliding hernias in the Shouldice repair (14) and plication darn (20) groups.
(4) NBA.com writer Steve Aschburner notes that this is essentially a no-win situation for him : Physically, Rose faces a darned-if-he-does, darned-if-he-doesn't dilemma.
(5) It’s a darn sight better,” laughed Juris, “than visiting him in jail”.
(6) The British method known as "nylon darn" has shown to be effective in preservation of deep groin anatomy.
(7) Though she pursued further studies and wrote, Aung San Suu Kyi did bring up children, darn socks and run grocery errands.
(8) Masuku also rejected the firebrand leftist Julius Malema and his Economic Freedom Fighters (EFF): "I read the EFF manifesto and I found some pretty good darned stuff there but they are so radical and so violent, they actually sound racist.
(9) That was pretty darn special, but only, you'll notice, a three-goal salvage job.
(10) This identified a considerable range in methods of repair, with a Moloney nylon darn being the sole method used by 35% of consultants, and the Shouldice technique, either alone or in combination with other methods, being used by 20%.
(11) Marc Ostwald from Monument Securities says: They haven't quite sold the complete amount but they got pretty darn close … Demand still very much more domestic than anything else.
(12) I got back into a program of recovery and life has been pretty darn good ever since,” she said.
(13) Another, tweaking an obscure bit of the film's dialogue, said: "I'm afraid you're just too darned disorganised."
(14) Darn, I was looking forward to seeing what sort of penalty Ozil would take ... 7.15pm BST Arsenal 2-2 Hull: half-time in extra-time Stay tuned!
(15) But, after days of patient care, one of the craft's wings has been stretched out into an approximation of its original shape, and the holes have been patched up with ovals of metal riveted on to the body work, like a large-scale piece of darning.
(16) He said: "Let's be frank, he [Brown] was a darn sight better than at prime minister's questions."
(17) Her speech is American-accented and peppered with "darn" and "have a nice day".
(18) patient age was 58.3(1.5) (range 20-84) years for Shouldice repair and 57.0(1.2) (range 18-85 years) for plication darn.
(19) The inguinal darn for recurrent inguinal hernias appears to have a lower recurrence rate than the reported 15% to 30% following other techniques.
(20) 'We’re too darned modest about what we do': Radio 3 boss Alan Davey's typical day Read more In that week’s Radio Times, the BBC’s director general, Sir William Haley, had set out the Third’s stall to the nation: “presenting the great classical repertoire in music and drama, and so far as they are broadcastable, in literature and the other arts … it will seek every evening to do something that is culturally satisfying and significant.” It was the year that everything changed for the arts in Britain.