(a.) Broken down with age; wasted and enfeebled by the infirmities of old age; feeble; worn out.
Example Sentences:
(1) In 1972, he launched a more ambitious plan by buying Hintlesham Hall, a decrepit grade-11 listed building in Suffolk, converting it into a home and three restaurants and taking over the Hintlesham festival held there.
(2) Some of Rio's most impressive architecture can still be found in and around Praça XV, but it has been throttled by modernity, its colonial charm obliterated by a concrete flyover, now black and decrepit, built directly over the top of it.
(3) Caine’s Guardian reader may be decrepit and disillusioned but still oozes wit and discerning taste.
(4) I really want to say thank you for the kind way my decrepit body was washed; how, in the middle of the night when I felt overwhelmed, a nurse stopped what she was doing and held my hand; the cake covered in Smarties the catering staff brought me for my birthday; the smiles and jokes with the staff to pass the long days; and Mr Burbos (one of the handsome consultant surgeons) who has been so generous with his time and care.
(5) One disingenuous objection to fairer taxing of property pleads for cash-poor, asset-rich old folk rattling around in drafty, decrepit mansions.
(6) This is not because it’s a decrepit, leaking ship, as often depicted, but because every modern healthcare system in the world will always need more money, more research and more beds, to give patients the best chance of treatment.
(7) The latest WHO figures underscore Ebola’s asymmetric spread, as it travels through densely populated communities with decrepit health facilities and poor public awareness campaigns.
(8) The Walworth Farce, which opens at the National Theatre next week, focuses on a tyrannical Irishman who has kept his two sons locked in a decrepit flat since the trio arrived in London almost two decades before.
(9) Another avenue is supporting the decrepit political opposition group that exists.
(10) Particularly striking is the fact that Britain will end up spending less as a proportion of its national income than even the US, the international byword for a decrepit public sector.
(11) They have already been biting the community – one of my children's school is a decrepit building, which was built in the 70s, a mass of concrete with rotten windows and broken doors.
(12) This did not happen overnight, and the sorry conduct of the referendum campaign was only the latest indication of the decrepit state of our politics: dominated by shameless appeals to fear, as though hope were a currency barely worth trading in, the British public had no such thing as a better nature, and a brighter future held no appeal.
(13) This fact, which confirms the decrepitation theorem, could explain the explosion inside the tissues observed in surgical application of the Nd:YAG laser.
(14) But the worst are shikumen s, no matter how historically significant or beautiful, that have become so decrepit and grimy from decades of overcrowding, heavy communal usage and minimal infrastructural investment by residents and local authorities.
(15) Many were in decrepit tower-blocks, sky high and matchstick small.
(16) I have known the squalid, damp bedrooms of the decrepit council house; the wait for the child benefit to buy the next meal; the reality of a bag of chips being a cheaper and more comforting alternative to a nutritious meal; the constant linkage of school to failure throughout our family generations; and the inevitable lure of cigarettes and alcohol to ease the pain.
(17) In tears and confusion, thousands of women, children and old men expelled from Srebrenica poured off buses yesterday at the decrepit air base in the town of Tuzla, northern Bosnia, accusing Serb rebels of murder and rape and the United Nations of indifference during the fall of the enclave.
(18) Earlier this month, more than 600 million people lost power when the country's decrepit electricity grid collapsed .
(19) The debt crisis that erupted in 2009 exposed the decrepit state of the country's structures.
(20) She looked forward to a life beyond the decrepit confines of the capital.
Senile
Definition:
(a.) Of or pertaining to old age; proceeding from, or characteristic of, old age; affected with the infirmities of old age; as, senile weakness.
Example Sentences:
(1) Hyperopia was more common in younger persons, but senile cataract, macular degeneration and palpebral dermatochalasis or blepharochalasis were more common in older persons.
(2) Mucosal drying medications and senile salivary gland atrophy seemed to contribute to the high frequency of sicca in this population with a lesser proportion of the subjects demonstrating previously undiagnosed Sjögren's and possible Sjögren's syndrome.
(3) Key findings include a progressive degeneration of these cholinergic neurons characterized by the formation of immunoreactively atypical NFT, the loss of intraneuronal lipofuscin, a lack of senile plaque and beta-amyloid deposition within the basal forebrain, and end-stage gliosis without residual extracellular NFT.
(4) This finding is consistent with the hypothesis that the majority of deaths attributed to presenile dementia and the majority of deaths from senile dementia are the result of the same disease entity.
(5) Diagnoses like neuroses, alcoholism, and senile dementia produced many visits by few patients.
(6) Her mother had only senile pigmented modification of the fundus and her three daughters had mild macular pigmented changes, like "salt and pepper."
(7) The reduced effectiveness of protection by antibody against viruses which had caused influenza disease 20--30 years ago was conducive to the spread of influenza Al cases among middle-aged and senile population.
(8) Since the detailed molecular events leading to the formation of amyloid-containing senile plaques of the Alzheimer's disease (AD) brain are incompletely understood, the present studies were undertaken to address this issue using a combination of molecular and cytochemical approaches.
(9) Recently in senile dementia of Alzheimer type, neuronal loss of cholinergic neurons in the substantia innominata is described.
(10) Whereas markedly high values of 1, 25-(OH)2D in plasma were found in some cases of primary hyperparathyroidism with prominent bone resorption, relatively low values were seen in some patients with chronic renal failure, senile osteoporosis, osteomalacia and hypercalcemia due to bone metastasis.
(11) The ultrastructure of the water-clear cells of the parathyroid glands in the starved adult and senile animals almost resembled that of the control adult and senile animals.
(12) The study of the drugs effective in the treatment of cognitive deficits and memory loss associated with senile dementia of the Alzheimer's type--tacrine and amiridin, acetylcholinesterase inhibitor physostigmine and nootrop piracetam on uptake of 3H-serotonin (3H-5-HT), 3H-adrenaline (3H-AD), 3H-noradrenaline (3H-HA), 2H-dopamine (3H-DA), 3H-gamma-aminobutyric acid (3H-GABA), 3H-glutamic acid (3H-GLU), 3H-aspartic acid (3H-ASP) and 3H-glycine (3H-GLI) showed that tacrine and amiridin (5 x 10(-5) M) statistically significantly (P less than 0.05) inhibited the uptake of 3H-DA and 3H-5-HT.
(13) The results are as follows: The neurites of senile DRG cells appeared 7 days later than the neurites of neonatal DRG cells.
(14) Although a trend was observed for TMA-DPH mobility to parallel histopathologic severity in hippocampal specimens, the biophysical changes did not appear to reflect a loss of neuronal membranes relative to glial membranes or the presence of senile plaques or neurofibrillary tangles.
(15) Corticotropin-releasing hormone-immunoreactivity (CRH-IR) and CRH receptors (binding capacity and affinity) were measured in postmortem cortical areas from depressed subjects, two groups of senile dementia of the Alzheimer type (SDAT), and age-, sex-, and postmortem-delay-matched controls.
(16) Anti-beta-peptide stained cerebrovascular and plaque core amyloid in all AD cases as well as cerebrovascular amyloid and senile plaque core amyloid in five elderly CJD cases.
(17) Senile dementia and admission other than from the patient's own home, were factors associated with a poorer long term outcome.
(18) In this study 40 fragments of human skin from 4 groups were included: children, adults, aged people with lesions of senile keratosis and without lesions of senile keratosis.
(19) To examine the efficacy of cholinergic enhancement in senile dementia of the Alzheimer type (SDAT), oral physostigmine was given to eight patients in a cross-over trial of three dose levels and a matching placebo.
(20) Here the presence and distribution within senile plaques of various epitopes of the beta-amyloid precursor protein (APP) are compared with the distribution of A beta P itself and markers for plaque neurites.