(n.) The act of reducing in rank, character, or reputation, or of abasing; a lowering from one's standing or rank in office or society; diminution; as, the degradation of a peer, a knight, a general, or a bishop.
(n.) The state of being reduced in rank, character, or reputation; baseness; moral, physical, or intellectual degeneracy; disgrace; abasement; debasement.
(n.) Diminution or reduction of strength, efficacy, or value; degeneration; deterioration.
(n.) A gradual wearing down or wasting, as of rocks and banks, by the action of water, frost etc.
(n.) The state or condition of a species or group which exhibits degraded forms; degeneration.
(n.) Arrest of development, or degeneration of any organ, or of the body as a whole.
Example Sentences:
(1) This bone could not be degraded by human monocytes in vitro as well as control bone (only 54% of control; P less than 0.003).
(2) Lp(a) also complexes to plasmin-fibrinogen digests, and binding increases in proportion to the time of plasmin-induced fibrinogen degradation.
(3) The rate of accumulation of degraded LDL products was lower in collagen gel cultures, but the final levels achieved were the same in the two substrata.
(4) At the highest dose of chloroquine tested (500 microM), a slightly greater increase in insulin binding and a decrease in insulin degradation were observed in fetal cells as compared with adult cells.
(5) Addition of extracellular mevalonate led to a concentration-dependent fall in both processes, although a higher concentration was required to produce the same effect on LDL degradation as on HMG-CoA reductase activity.
(6) Radioiodinated a-factor was used to identify the a-factor-degrading activity, which is cell associated, endoproteolytic, and not required for response to pheromone.
(7) Densitometric analysis of myofibrillar proteins separated with sodium dodecyl sulfate-polyacrylamide gel electrophoresis indicated that troponin I and troponin T were degraded during 60 minutes of CGI.
(8) In addition, we found apyrase activity (which degrades ATP and ADP to AMP and orthophosphate) and an anticoagulant.
(9) Degradation of both viral and host DNA with micrococcal nuclease and spleen phosphodiesterase indicated that CdG was incorporated primarily into internal positions in both DNAs.
(10) In vitro studies showed that BOF-A2 was rapidly degraded to EM-FU and CNDP in homogenates of the liver and small intestine of mice and rats, and in sera of mice, rats and human, and the conversion of EM-FU to 5-FU occurred only in the microsomal fraction of rat liver in the presence of NADPH.
(11) Only PPACK completely inhibited changes in fibrin degradation products, plasminogen and alpha 2-antiplasmin.
(12) On the other hand, if we correct for the population of HMM with degraded light chain 2, the difference in the binding constants in the presence and absence of Ca2+ may be as great as 5-fold.
(13) When cultures were pulse labeled for 15 min and then incubated under chase conditions for 105 min, the amount of degraded collagen attained a value equal to approximately 20% of the amount synthesized during the labeling period; the data were fit with a simple exponential function that had a 40-min rise time and a 12-min lag time.
(14) The mode of ribosome degradation under this condition is discussed in terms of differential appearance of these intermediate particles.
(15) Degraded visual acuity had a significant effect on cadence, foot placement, and foot clearance, but visual surround conditions did not.
(16) The resistance of GSA 65 to proteolytic degradation, together with previous immunofluorescence data that indicate the antigen is an integral part of the G. lamblia cyst wall, suggests that this molecule may play a role in maintaining the integrity of the cyst in vivo.
(17) 5% of the degradation resulted from enzymatic activity in the culture medium, presumably due to secretion of proteolytic enzymes by the cells.
(18) At 37 degrees C, 125I-labeled TNF-alpha was rapidly internalized and degraded in L-929, U-937 and LAK cells.
(19) Recovery after EEDQ administration showed that both receptor production rate and degradation rate constants of anterior pituitary D2 and striatal D1 receptors were slowed after chronic estradiol treatment, whereas recovery rates for striatal D2 dopamine receptors were unaffected.
(20) The specific rates of degradation of L-arginine-AMC, gly-proline-AMC, N-alpha-benzoyl-L-arginine-AMC and N-[p-toluene-sulphonyl]gly-pro-arginine-AMC were significantly greater in that group, indicating that the composition of their gingival crevicular fluid was different from that of the gingivitis group.
Indignity
Definition:
(n.) Any action toward another which manifests contempt for him; an offense against personal dignity; unmerited contemptuous treatment; contumely; incivility or injury, accompanied with insult.
Example Sentences:
(1) If the villagers fail to respect the social code, by not using her new name or by reminding her of her indignity, they have to perform a reparative ritual, at which a goat is sacrificed.
(2) "This unfair and unequal treatment means that children with disabilities – already so disadvantaged – suffer further indignities.
(3) Asked by the BBC whether he would apologise or comply with a demand from Miliband for him to resign, he said: "Well, if someone can explain anything that I said as factually incorrect of course I would consider it...People are slightly spinning and loading into what I said in a way to get false indignation."
(4) The ALA collects information on which books are objected to and reports on prominent recurring themes that tend to generate moral or ideological indignation.
(5) We accept on behalf of our client that public interest demands nothing but total indignation and condemnation from all media reporting but such reporting ought not to persist at the expense of undermining Mr Barklie’s right to a fair trial.” His lawyers said the Metropolitan police had confirmed ”that arrangements were in hand to take the investigation to the next stage”.
(6) Not since Novak Djokovic beat him 6-1, 6-0 in the semi-final of the 2007 Miami Masters – when Murray was injured – has the Scot had to suffer such indignity.
(7) However indignant Hollande may have been about a glossy celebrity magazine revealing the details of his affair with a French actress – and he said his indignation was "total" – whatever reflections and considerations were going through the presidential grey matter on Tuesday morning, the idea of sitting down and drafting his resignation was almost certainly not among them.
(8) The Duchess of Cambridge, due to give birth in the next couple of weeks, will not suffer the indignities of, say, Mary of Modena in 1688, forced to give birth in front of an audience of 200 and still accused of a bit of business with bedpan and changeling.
(9) Last year, in a continuing campaign to improve policing , he produced a book brimming with indignation.
(10) Imagine the dizzy swoon of indignation deprivation: what's upsetting is there's nothing to get upset about.
(11) And we are increasing the number of single rooms in the NHS to ensure no patient suffers this indignity when it is unjustified."
(12) But the State Department's indignation over the leaks of allegedly valuable secrets was, and remains, preposterous.
(13) 2.42am BST 6 mins Jamaica indignant as a corner is awarded when they thought they were getting a foul.
(14) The human pressure cooker could not contain his indignation at having to watch Channel 4 news reporter, Fatima Manji , cover the tragic attack in Nice.
(15) Righteous indignation was tweeted and retweeted, celebrities piled on the pressure, pundits sharpened their quills.
(16) I cried at the time, tears of sadness for her, guilt for me (I should be able to do more), and indignation and anger about the unfairness of it all.
(17) It was classic Loach territory: exploitation, the indignity of unemployment, the resilience and humour of working-class people.
(18) When Elinor and Marianne debate the importance of money in the company of Edward, Marianne reacts indignantly to Elinor's declaration that happiness has much to do with "wealth": "'Elinor, for shame!'
(19) It was found that in a somewhat cyclical succession, patient deviance was followed by the staff's spontaneous moral indignation.
(20) For the next five years at least that is an indignity he will not have to worry about.