(v. t.) To reduce from a higher to a lower rank or degree; to lower in rank; to deprive of office or dignity; to strip of honors; as, to degrade a nobleman, or a general officer.
(v. t.) To reduce in estimation, character, or reputation; to lessen the value of; to lower the physical, moral, or intellectual character of; to debase; to bring shame or contempt upon; to disgrace; as, vice degrades a man.
(v. t.) To reduce in altitude or magnitude, as hills and mountains; to wear down.
(v. i.) To degenerate; to pass from a higher to a lower type of structure; as, a family of plants or animals degrades through this or that genus or group of genera.
Example Sentences:
(1) This bone could not be degraded by human monocytes in vitro as well as control bone (only 54% of control; P less than 0.003).
(2) Lp(a) also complexes to plasmin-fibrinogen digests, and binding increases in proportion to the time of plasmin-induced fibrinogen degradation.
(3) The rate of accumulation of degraded LDL products was lower in collagen gel cultures, but the final levels achieved were the same in the two substrata.
(4) At the highest dose of chloroquine tested (500 microM), a slightly greater increase in insulin binding and a decrease in insulin degradation were observed in fetal cells as compared with adult cells.
(5) Addition of extracellular mevalonate led to a concentration-dependent fall in both processes, although a higher concentration was required to produce the same effect on LDL degradation as on HMG-CoA reductase activity.
(6) Radioiodinated a-factor was used to identify the a-factor-degrading activity, which is cell associated, endoproteolytic, and not required for response to pheromone.
(7) Densitometric analysis of myofibrillar proteins separated with sodium dodecyl sulfate-polyacrylamide gel electrophoresis indicated that troponin I and troponin T were degraded during 60 minutes of CGI.
(8) In addition, we found apyrase activity (which degrades ATP and ADP to AMP and orthophosphate) and an anticoagulant.
(9) Degradation of both viral and host DNA with micrococcal nuclease and spleen phosphodiesterase indicated that CdG was incorporated primarily into internal positions in both DNAs.
(10) In vitro studies showed that BOF-A2 was rapidly degraded to EM-FU and CNDP in homogenates of the liver and small intestine of mice and rats, and in sera of mice, rats and human, and the conversion of EM-FU to 5-FU occurred only in the microsomal fraction of rat liver in the presence of NADPH.
(11) Only PPACK completely inhibited changes in fibrin degradation products, plasminogen and alpha 2-antiplasmin.
(12) On the other hand, if we correct for the population of HMM with degraded light chain 2, the difference in the binding constants in the presence and absence of Ca2+ may be as great as 5-fold.
(13) When cultures were pulse labeled for 15 min and then incubated under chase conditions for 105 min, the amount of degraded collagen attained a value equal to approximately 20% of the amount synthesized during the labeling period; the data were fit with a simple exponential function that had a 40-min rise time and a 12-min lag time.
(14) The mode of ribosome degradation under this condition is discussed in terms of differential appearance of these intermediate particles.
(15) Degraded visual acuity had a significant effect on cadence, foot placement, and foot clearance, but visual surround conditions did not.
(16) The resistance of GSA 65 to proteolytic degradation, together with previous immunofluorescence data that indicate the antigen is an integral part of the G. lamblia cyst wall, suggests that this molecule may play a role in maintaining the integrity of the cyst in vivo.
(17) 5% of the degradation resulted from enzymatic activity in the culture medium, presumably due to secretion of proteolytic enzymes by the cells.
(18) At 37 degrees C, 125I-labeled TNF-alpha was rapidly internalized and degraded in L-929, U-937 and LAK cells.
(19) Recovery after EEDQ administration showed that both receptor production rate and degradation rate constants of anterior pituitary D2 and striatal D1 receptors were slowed after chronic estradiol treatment, whereas recovery rates for striatal D2 dopamine receptors were unaffected.
(20) The specific rates of degradation of L-arginine-AMC, gly-proline-AMC, N-alpha-benzoyl-L-arginine-AMC and N-[p-toluene-sulphonyl]gly-pro-arginine-AMC were significantly greater in that group, indicating that the composition of their gingival crevicular fluid was different from that of the gingivitis group.
Denigrate
Definition:
(v. t.) To blacken thoroughly; to make very black.
(v. t.) Fig.: To blacken or sully; to defame.
Example Sentences:
(1) What are New York values?” he asked the crowd, alluding to Cruz’s vague denigration of those “liberal” values in a January debate.
(2) What if the ad vilified African Americans, or Jews, or any other group for which public denigration is less permissible?
(3) 'Fashionable theories and permissive claptrap set the scene for a society in which old values of discipline and restraint were denigrated.'
(4) And this in the face of the most concerted campaign of denigration any Labour leader has ever endured in such a short space of time.
(5) And while Altmejd presents sexual scenes of cartoonish horror and disgust, Lucas's art has embraced lavatorial humour, abjection, self-denigration, the pithy sculptural one-liner and the obscene gesture.
(6) This week we see that the ramifications of corporate prostitution continue to hurt her as juniors (looking at you, Harry Crane) use the knowledge of what happened to both blackmail the company and denigrate her.
(7) Such beliefs denigrate certain aspects of female sexuality.
(8) Their role was to challenge, even denigrate, the views of "insiders", to demand value for money, to impose performance management, to root out endemic "failure" and to insist on what they saw as customer satisfaction.
(9) Nobody should denigrate the achievements of those who received their results in the past few days.
(10) Michael Meacher MP Labour, Oldham West and Royton • How dare Norman Warner and Jack O'Sullivan denigrate the NHS in such strident terms?
(11) "Michael thinks it is important not to denigrate the patriotism, honour and courage demonstrated by ordinary British soldiers in the first world war."
(12) Childcare remains resolutely low-status, and Slaughter thinks this is partly due to the attitude, "'well, it's women's work', and since we denigrate women, we denigrate caregiving."
(13) Barnaby Joyce defends halal after Coalition MPs express concern Read more “It is against the law to vilify Jews and it is not politically correct to denigrate blacks or gays.
(14) James Cooke, author of one of the most popular English surgical textbooks of the seventeenth century, in an amusing and previously unnoted reference, adds to this denigration and helps to explain why nasal reconstruction became a subject of satire in England.
(15) In his piece, Gove criticises historians and TV programmes that denigrate patriotism and courage by depicting the war as a "misbegotten shambles".
(16) A significant proportion of the comments denigrated and dismissed her.
(17) They reached this conclusion after finding he allowed payment to influence his actions in parliamentary proceedings, failed to declare his interests on appropriate occasions, failed to recognise that his actions were not in accordance with his expressed views on acceptable behaviour, repeatedly denigrated fellow MPs both individually and collectively, and used racially offensive language.
(18) But even as the city attempted to clean up the mess, another group of at least four San Francisco police officers was exchanging text messages that mocked the community response to the scandal, used racist slurs and denigrated LGBT people.
(19) Criticism of Allen's video followed almost immediately after its release on Tuesday , with several bloggers and numerous tweeters calling out Hard Out Here's "denigration of black female bodies".
(20) He is denigrating and he is talking down our democracy,” she said.